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Diabetes complications and extracellular vesicle therapy

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Abstract

Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cell-based therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.

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Acknowledgements

The authors would like to acknowledge Daniel Dan Liu for critical reading and English editing of the manuscript.

Funding

The Lundbeck foundation, grant R303-2018–3148 supported this work.

Author information

Authors and Affiliations

  1. Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Setareh Soltani

  2. Medical Biology Research Center, Health Technology Institute, Kermanshah, University of Medical Sciences, Kermanshah, Iran

    Kamran Mansouri

  3. Regenerative Medicine and Cellular Pharmacology Laboratory (HECRIN), Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary

    Shahram Parvaneh

  4. Research Institute of Translational Biomedicine, Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary

    Shahram Parvaneh

  5. Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA

    Avnesh S. Thakor & Reza Yarani

  6. Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark

    Flemming Pociot & Reza Yarani

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  1. Setareh Soltani
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Soltani, S., Mansouri, K., Parvaneh, S. et al. Diabetes complications and extracellular vesicle therapy. Rev Endocr Metab Disord 23, 357–385 (2022). https://doi.org/10.1007/s11154-021-09680-y

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