Reviews in Endocrine and Metabolic Disorders

, Volume 17, Issue 3, pp 283–286 | Cite as

Skin manifestations of Cushing’s syndrome

  • Constantine A. StratakisEmail author


Among the most common diagnostic manifestations of Cushing’s syndrome (CS) are those involving the skin; they include violaceous striae, facial acne, hirsutism, acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy bruisability. Fortunately, most resolve within a year or two after cure of CS, although light-colored striae can persist for years depending on the age of the patients. AN, Hp, and bruisability usually resolve within months after cure in almost all ages. Facial plethora (along with acne and other facial skin changes) is a typical sign of CS that is due to increased perfusion. It resolves immediately after curative therapy of CS. Typically, the severity of the manifestations does not correlate with the biochemical indices of the disease, pointing to age, gender, genetic and skin-type differences that determine the cutaneous manifestations of CS.


Cushing’s syndrome Glucocorticoids Skin Acne Plethora Hyperpigmentation Bruise Striae Hirsutism Acanthosis 



This review was supported by the research project Z01-HD008920 (Principal Investigator: Dr. Constantine A Stratakis) of the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

Compliance with ethical standards

Conflict of interest

The author declares that he has no conflict of interest.


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Copyright information

© Springer Science+Business Media New York (outside the USA) 2016

Authors and Affiliations

  1. 1.Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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