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Brain regulation of energy balance and body weight

Reviews in Endocrine and Metabolic Disorders volume 14, pages 387–407 (2013)Cite this article

Abstract

Body weight is determined by a balance between food intake and energy expenditure. Multiple neural circuits in the brain have evolved to process information about food, food-related cues and food consumption to control feeding behavior. Numerous gastrointestinal endocrine cells produce and secrete satiety hormones in response to food consumption and digestion. These hormones suppress hunger and promote satiation and satiety mainly through hindbrain circuits, thus governing meal-by-meal eating behavior. In contrast, the hypothalamus integrates adiposity signals to regulate long-term energy balance and body weight. Distinct hypothalamic areas and various orexigenic and anorexigenic neurons have been identified to homeostatically regulate food intake. The hypothalamic circuits regulate food intake in part by modulating the sensitivity of the hindbrain to short-term satiety hormones. The hedonic and incentive properties of foods and food-related cues are processed by the corticolimbic reward circuits. The mesolimbic dopamine system encodes subjective “liking” and “wanting” of palatable foods, which is subjected to modulation by the hindbrain and the hypothalamic homeostatic circuits and by satiety and adiposity hormones. Satiety and adiposity hormones also promote energy expenditure by stimulating brown adipose tissue (BAT) activity. They stimulate BAT thermogenesis mainly by increasing the sympathetic outflow to BAT. Many defects in satiety and/or adiposity hormone signaling and in the hindbrain and the hypothalamic circuits have been described and are believed to contribute to the pathogenesis of energy imbalance and obesity.

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Acknowledgements

This work was supported by National Institute of Health (NIH) grants RO1 DK 065122, RO1 DK091591 and RO1 DK094014.

Conflict of interest

Liangyou Rui has no conflict of interests in the data presented in this review.

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  1. Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109-0622, USA

    Liangyou Rui

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Rui, L. Brain regulation of energy balance and body weight. Rev Endocr Metab Disord 14, 387–407 (2013). https://doi.org/10.1007/s11154-013-9261-9

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Keywords

  • Food intake
  • Energy expenditure
  • Obesity
  • Hypothalamus
  • Brainstem
  • Mesolimbic dopamine reward system
  • Brown fat-adaptive thermogenesis
  • Satiety hormones
  • Adiposity hormones
  • Leptin resistance
  • Insulin resistance