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Novel mechanisms of protein synthesis in diabetic nephropathy—role of mRNA translation

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Abstract

Ambient protein levels are affected by both synthesis and degradation. Synthesis of a protein is regulated by transcription and messenger RNA (mRNA) translation. Translation has emerged as an important site of regulation of protein expression during development and disease. It is under the control of distinct factors that regulate initiation, elongation and termination phases. Regulation of translation occurs via signaling reactions, guanosine diphosphate–guanosine triphosphate binding and by participation of non-coding RNA species such as microRNA. Recent work has revealed an important role for translation in hypertrophy, matrix protein synthesis, elaboration of growth factors in in vivo and in vitro models of diabetic nephropathy. Studies of translation dysregulation in diabetic nephropathy have enabled identification of novel therapeutic targets. Translation of mRNA is a fertile field for exploration in investigation of kidney disease.

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Acknowledgements

Studies were supported by grants from the NIH- DK061597 (O'Brien Kidney Research Center, BSK, JLB), NIH-DK077295 (BSK), American Diabetes Association—7-05-RA-60 (BSK), VA Research Service (BSK, GGC, JLB), Juvenile Diabetes Research Foundation—3-2007-245 (MMM/BSK), NIH—DK050190 (GGC), American Heart Association SDG 0630283N (DF). GGC is a recipient of the VA Research Career Scientist Award.

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  1. O’Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA

    B. S. Kasinath, M. M. Mariappan, K. Sataranatarajan, M. J. Lee, G. Ghosh Choudhury & D. Feliers

  2. Department of Medicine, MC 7882, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA

    B. S. Kasinath

  3. South Texas Veterans Health Care System, San Antonio, TX, USA

    B. S. Kasinath, M. M. Mariappan, K. Sataranatarajan, M. J. Lee, G. Ghosh Choudhury & D. Feliers

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Kasinath, B.S., Mariappan, M.M., Sataranatarajan, K. et al. Novel mechanisms of protein synthesis in diabetic nephropathy—role of mRNA translation. Rev Endocr Metab Disord 9, 255–266 (2008). https://doi.org/10.1007/s11154-008-9091-3

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