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Enantioselective hydrogenation of (E)-2-methyl-2-butenoic acid over cinchonidine modified Pd catalyst. Effect of the structure of achiral amine additives

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Abstract

The effect of the structure of the achiral primary amine additive on the enantioselective heterogeneous catalytic hydrogenation of (E)-2-methyl-2-butenoic acid over cinchonidine modified Pd/Al2O3 was studied. It was found that a variety of amines increase the enantioselectivity, which was always accompanied by decrease in the initial rate of the hydrogenations. Based on these results, the participation of the amine additive in the formation of the intermediate complex responsible for enantioselection was suggested. A decrease in the reaction temperature resulted in further increase in the optical purity of the product up to 67%, the highest value reported in the hydrogenation of unsaturated aliphatic acids in this heterogeneous catalytic system so far.

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Authors and Affiliations

  1. Stereochemistry Research Group of the Hungarian Academy of Sciences, University of Szeged, Dóm tér 8, H-6720, Szeged, Hungary

    György Szőllősi & Mihály Bartók

  2. Department of Organic Chemistry, University of Szeged, Szeged, Hungary

    Zsolt Makra & Mihály Bartók

Authors
  1. György Szőllősi
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  2. Zsolt Makra
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  3. Mihály Bartók
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Correspondence to György Szőllősi.

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Szőllősi, G., Makra, Z. & Bartók, M. Enantioselective hydrogenation of (E)-2-methyl-2-butenoic acid over cinchonidine modified Pd catalyst. Effect of the structure of achiral amine additives. React Kinet Catal Lett 96, 319–325 (2009). https://doi.org/10.1007/s11144-009-5513-9

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  • DOI: https://doi.org/10.1007/s11144-009-5513-9

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