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Influence of High-Intensity Terahertz Radiation on the Differentiation of Human Neural Progenitor Cells

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Radiophysics and Quantum Electronics Aims and scope

We present the results of studying the impact of high-intensity terahertz pulses on the differentiation of induced human neural progenitor cells (drNPCs). The differentiation was estimated using the immunocytochemical analysis, i.e., the marker of the undifferentiated cells (SOX2) and the markers of the neuronal (β-III-tubulin and MAP2b) and glial (GFAP) phenotype. The cell exposure was performed by terahertz pulses with an intensity of 21 GW/cm2 and an electric field of 2.8 MV/cm for 30 min. As a result of exposure, the phenotype of induced neural progenitor cells did not differ from that of unexposed cells and the appearance of mature neurons or glial cells was not detected. The ability of the terahertz radiation to cause effects in neural cell cultures apparently requires further studies for higher exposure intensity or duration.

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Authors and Affiliations

  1. Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow, Russia

    D. S. Sitnikov & I. V. Ilina

  2. Federal Research and Clinical Center for Special Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency (FMBA) of Russia, Moscow, Russia

    V. A. Revkova, M. A. Konoplyannikov, V. A. Kalsin & V. P. Baklaushev

  3. V. A. Engelgardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia

    V. A. Revkova & V. P. Baklaushev

  4. Science and Technology University “Sirius,”, Sochi, Russia

    R. O. Shatalova

  5. Institute of Regenerative Medicine of Sechenov University, Moscow, Russia

    M. A. Konoplyannikov

  6. Federal Center for Brain and Neural Technologies of the Federal Medical and Biological Agency (FMBA) of Russia, Moscow, Russia

    V. A. Kalsin & V. P. Baklaushev

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  1. D. S. Sitnikov
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  2. V. A. Revkova
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  3. I. V. Ilina
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  4. R. O. Shatalova
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  7. V. P. Baklaushev
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Correspondence to D. S. Sitnikov.

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Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Radiofizika, Vol. 66, Nos. 7–8, pp. 683–696, April 2023. Russian https://doi.org/10.52452/00213462_2023_66_07_683

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Sitnikov, D.S., Revkova, V.A., Ilina, I.V. et al. Influence of High-Intensity Terahertz Radiation on the Differentiation of Human Neural Progenitor Cells. Radiophys Quantum El (2024). https://doi.org/10.1007/s11141-024-10321-y

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  • DOI: https://doi.org/10.1007/s11141-024-10321-y

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