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The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life

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Abstract

Purpose

Both metabolic syndrome (MetS) and cognitive dysfunction impair health-related quality of life (HRQOL). This study aims to determine whether individuals experiencing both MetS and cognitive dysfunction have lower HRQOL.

Methods

This cross-sectional study enrolled 567 participants who attended outpatient clinics at a medical center in northern Taiwan. MetS was diagnosed according to the modified criteria for the Asian population. Cognitive function was categorized as normal, mild cognitive dysfunction, and advanced cognitive dysfunction according to the score of the Montreal Cognitive Assessment, Taiwanese version. HRQOL was assessed using the SF-36v2® Health Survey (SF-36v2). The associations of the comorbidity status of MetS and cognitive dysfunction with HRQOL were analyzed using linear regression models, adjusting for age, sex, marital status, education level, income groups, and activities of daily living.

Results

Out of 567 participants, 33 (5.8%) had MetS with mild cognitive dysfunction, and 34 (6.0%) had MetS with advanced cognitive dysfunction. Participants with both MetS and advanced cognitive dysfunction exhibited the lowest scores in the physical component summary and almost all scales of HRQOL. MetS exacerbated the inverse association between mild cognitive dysfunction and the mental component summary. For those with MetS, the scores on scales of role physical, bodily pain, vitality, and social functioning worsened as cognitive function deteriorated (all Ptrend<0.05).

Conclusion

As the severity of comorbidity between MetS and cognitive dysfunction varies, patients exhibited poorer performance in different aspects of HRQOL. Future research is needed to find solutions to improve HRQOL for patients with both MetS and cognitive dysfunction.

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Data availability

The raw data is available on the Open Science Framework (OSF): https://osf.io/fhbe5/?view_only=b1b3a182642d44aea54bfe9ca677f83b.

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Funding

This work was supported by grants from Taipei Veterans General Hospital. [Grant number: V109E-005-4, V110E-005-4, V111E-006-4, V112E-004-4]

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Authors and Affiliations

  1. Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan

    Yi-Hsuan Lin

  2. School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Yi-Hsuan Lin, Hsiao-Ting Chang, Yen-Feng Wang, Jong-Ling Fuh, Shuu-Jiun Wang, Harn-Shen Chen, Ming-Hwai Lin, Tzeng-Ji Chen & Shinn-Jang Hwang

  3. Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou Dist, Taipei City, 11217, Taiwan

    Yi-Hsuan Lin, Hsiao-Ting Chang, Sih-Rong Li, Ming-Hwai Lin, Tzeng-Ji Chen & Shinn-Jang Hwang

  4. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

    Yen-Feng Wang, Jong-Ling Fuh & Shuu-Jiun Wang

  5. Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Harn-Shen Chen

  6. Department of Family Medicine, Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County, Taiwan

    Tzeng-Ji Chen

  7. Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan

    Tzeng-Ji Chen

  8. Department of Family Medicine, En Chu Kong Hospital, New Taipei City, Taiwan

    Shinn-Jang Hwang

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Contributions

Yi-Hsuan Lin designed the study, conducted statistical analysis, interpreted the results, and wrote the paper. Hsiao-Ting Chang designed the study, organized the original data, coordinated the research, and editing. Yen-Feng Wang, Jong-Ling Fuh, and Shuu-Jiun Wang planned the research direction and assisted in collecting the original data. Harn-Shen Chen assisted in formulating the research question and study design. Sih-Rong Li assisted in the enrollment of participants and maintaining the original data. Ming-Hwai Lin, Tzeng-Ji Chen, and Shinn-Jang Hwang contributed to conceptualization, review, and editing.

Corresponding author

Correspondence to Hsiao-Ting Chang.

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Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Committee of Taipei Veterans General Hospital, Taipei, Taiwan, on May 9, 2022 (Protocol Code: 2020-06-001 A).

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All participants in this study provided written informed consent before participating in the research.

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The authors declare that they have no conflict of interest.

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Lin, YH., Chang, HT., Wang, YF. et al. The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life. Qual Life Res (2024). https://doi.org/10.1007/s11136-024-03784-z

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