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The impact of endoscopic treatment on health-related quality of life in patients with Barrett’s neoplasia: a scoping review

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Abstract

Purpose

The objective of this scoping review is to understand the extent, type of evidence, and overall findings in relation to the impact of endoscopic treatment (ET) on health-related quality of life (HR-QoL) in patients with Barrett’s dysplasia and early oesophageal cancer.

Methods

A comprehensive search was conducted for literature between 2001 and 2022 in computerised databases (PubMed, Embase, Cochrane Library, and CINAHL Complete). Additionally, sources of unpublished literature were searched in Google Advanced Search. After title and abstract checking, full-text papers were retrieved. Data were extracted, synthesised, key information tabulated, and a narrative synthesis completed.

Results

Six studies were included in the final analysis. Twelve different survey tools were utilised across all studies. Study designs included three randomised controlled studies, two prospective observational studies, and a single retrospective observational study. The average age of study participants ranged from 60.3 to 71.0 years. Two studies evaluated HR-QoL as primary outcome measures, but most research evaluated HR-QoL as a secondary outcome. Health domains evaluated in the studies focussed on the biophysical and psychosocial aspects of quality of life.

Conclusion

A small number of research studies have been conducted in this area. Due to the heterogeneity and small number of included studies, it was difficult to draw conclusions about the impact of specific ET types on HR-QoL. Overall, there were perceived psychological benefits while undergoing ET. Future research could target specific ET subtypes and measure HR-QoL at baseline and post-procedures in the short and long term.

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Data availability

Data supporting this study are included within the article and/or supporting materials.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Royal Brisbane and Women’s Hospital, Herston, QLD, 4029, Australia

    Kimberley Ryan, Erin Lowe & Florian Grimpen

  2. School of Nursing, Faculty of Health, Queensland University of Technology, Herston, Australia

    Kimberley Ryan

  3. The University of Queensland, UQ Library, Herston, QLD, 4006, Australia

    Natalie Barker

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  1. Kimberley Ryan
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  2. Erin Lowe
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Contributions

All authors contributed to the study conception and design. Material preparation and data collection were performed by KR, EL, and NB. Analysis and first draft of the manuscript were written by KR and FG. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Kimberley Ryan.

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This is a scoping review and is secondary research, and as such it was not required to undergo review by a Research Ethics Committee.

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Ryan, K., Lowe, E., Barker, N. et al. The impact of endoscopic treatment on health-related quality of life in patients with Barrett’s neoplasia: a scoping review. Qual Life Res 33, 607–617 (2024). https://doi.org/10.1007/s11136-023-03528-5

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