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The association between diabetic complications and health-related quality of life in patients with type 2 diabetes: a cross-sectional study from Iran

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Abstract

Introduction

This study aimed to investigate the health-related quality of life (HRQoL) of type 2 diabetic patients and its relationship with the complications of diabetes in Farashband County, Fars, Iran.

Methods

Data of this cross-sectional study were collected by a researcher-made demographic questionnaire, EuroQol-5 Dimensions questionnaire (EQ-5D) and Visual Analog Scale (VAS) and also from patient records. Multivariate regression model was used to investigate the net effect of diabetes complications on HRQoL after controlling for other independent variables.

Results

A total of 685 patients with a mean age of 58.36 and a disease duration of 7.64 years participated in the study. The mean EQ-5D and EQ-VAS scores of all patients were 0.64 and 56.53, respectively. The HRQoL dimensions in which the largest portions of the population had problems were Pain/Discomfort (77.23%) and Anxiety/Depression (63.50%). Among the studied diabetic patients, women, divorcees, and widows were more likely to report problems in all dimensions of HRQoL, and people without complications, people with university degrees, and employed people were more likely to report fewer problems in these dimensions (P < 0.05). After controlling for the effect of all independent variables in the multivariate regression model, a significant negative relationship was found between diabetes complications and EQ-5D: β =  − 0.149 (95% CI − 0.186, − 0.112) and EQ-VAS: β =  − 6.697 (95% CI − 9.947, − 3.747). This indicates that for each additional diabetic complication, 0.149 and 6.697 units of EQ-5D Index and EQ-VAS were reduced, respectively.

Conclusion

This study indicated that type 2 diabetic patients in the studied region, especially those with complications, suffer from poor HRQoL. Therefore, more attention should be paid to the main determinants of HRQoL when adopting policies for diabetes management in order to ultimately improve the HRQoL of these patients.

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Data availability

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. No additional data are available.

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Acknowledgements

The authors would like to thank all participants in this study.

Funding

This study was funded and supported by Iran University of Medical Sciences (IUMS), Tehran. Iran; Grant No. 96-03-136-30531.

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Authors and Affiliations

  1. Department of Health Economics‚ School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran

    Hassan Karami

  2. Department of Management and Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Maryam Shirvani Shiri, Ranaa Sarvari Mehrabadi & Somayeh Afshari

  3. Health Management and Economics Research Center, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran

    Aziz Rezapour

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  1. Hassan Karami
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  2. Maryam Shirvani Shiri
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  3. Aziz Rezapour
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Contributions

Conceived and designed the experiments: HK AZ MSH. Performed the experiments: HK AZ MSH. Analyzed the data: HK MSH Contributed reagents/materials/analysis tools: HK AZ MSH RS SA. Wrote the paper: HK AZ MSH RS SA.

Corresponding author

Correspondence to Aziz Rezapour.

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The authors declare that they have no competing interests.

Ethical approval

This study was approved by the ethics committee of Iran University of Medical Sciences (IR.IUMS.REC.1396.30531). All subjects provided informed consent to participate in the study. The study was performed in accordance with the Declaration of Helsinki of 1964, as revised in 2013, concerning human and animal rights.

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Karami, H., Shirvani Shiri, M., Rezapour, A. et al. The association between diabetic complications and health-related quality of life in patients with type 2 diabetes: a cross-sectional study from Iran. Qual Life Res 30, 1963–1974 (2021). https://doi.org/10.1007/s11136-021-02792-7

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