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Table 7 HIT-6 total score by known groups, defined by PGIC and headache day categorizations, at Week 12

From: Reliability and validity of the 6-item Headache Impact Test in chronic migraine from the PROMISE-2 study

Measure n Mean (SD)
PGIC
 Very much improved or much improved 525 54.97 (7.38)
 Minimally improved or worse 498 62.48 (6.33)
 Difference   7.50 (6.89)
 Cohen’s d 1.09
 p value  < 0.0001
Headache days (weeks 9‒12)
 ≥ 15 days (“Chronic”) 389 62.43 (5.95)
 < 15 days (“non-Chronic”) 635 56.27 (7.97)
 Difference   6.15 (7.27)
 Cohen’s d 0.88
 p value  < 0.0001
  1. PGIC Patient Global Impression of Change, SD standard deviation