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A head-to-head comparison of measurement properties of the EQ-5D-3L and EQ-5D-5L in acute myeloid leukemia patients

Quality of Life Research volume 30, pages 855–866 (2021)Cite this article

Abstract

Purpose

This study aimed to compare the measurement properties of EQ-5D-3L(3L) and EQ-5D-5L(5L) in patients with acute myeloid leukemia (AML) in China.

Methods

We consecutively recruited 168 patients with AML from three tertiary hospitals to complete two rounds of interviews using the two versions of the EQ-5D. We compared (i) the ceiling effect using the McNemar’s test, (ii) test–retest reliability using intraclass correlation coefficient (ICC) and Cohen’s weighted Kappa, (iii) convergent validity using Spearman’s rank correlation coefficient (r) and iv) discriminatory ability using F statistic and area under the receiver operating characteristics curve (AUROC) of the 5L and the 3L.

Results

The 5L descriptive system showed significantly lower ceiling effects in comparison to the 3L descriptive system (p < 0.001). While 5L showed superior reproducibility (Cohen’s weighted Kappa = 0.56–0.67 and ICC = 0.89), both instruments exhibited good test–retest reliability. Even though both 3L and 5L showed good convergent and known-groups validity, 5L showed better convergent validity and discriminatory ability.

Conclusion

The current study found both 3L and 5L to be suitable for use in AML patients. However, 5L showed superior measurement properties compared to 3L. Thus, 5L could be the preferred instrument over 3L for use in AML patients.

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Acknowledgements

We are especially grateful to the study participants who have suffered from leukemia and have never given up. We also acknowledge the interviewers for helping with the data collection.

Funding

This work was supported by the National Social Science Foundation of China (Grant No. 71974048, 71503062) and by the China Medical Board (CMB-19–308).

Author information

Author notes

    Affiliations

    1. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

      Hongjuan Yu

    2. Southern University of Science and Technology Hospital, Shenzhen, 518000, China

      Hongjuan Yu

    3. School of Health Management, Harbin Medical University, Harbin, 150086, China

      Xueyun Zeng, Mingjie Sui, Rui Liu & Weidong Huang

    4. National University Singapore Saw Swee Hock School of Public Health, Singapore, Singapore

      Rachel Lee-Yin Tan & Nan Luo

    5. Bejing Tsinghua Changgung Hospital, Beijing, 102218, China

      Jinjin Yang

    Author notes

    1. Hongjuan Yu, Xueyun Zeng and Mingjie Sui contributed equally to this article. They are co-first authors.

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      Contributions

      HY, XZ, MS and RL drafted the manuscript and performed the data analysis. JY, CL and JX collected the data and interpreted the results. WH, HY and HY contributed to study design as well as drafting and editing of the manuscript. RLYT and NL contributed to the reviewing and editing of the manuscript. All authors read and approved the final manuscript.

      Corresponding author

      Correspondence to Weidong Huang.

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      Conflict of interest

      NL is a member of the EuroQol group. All other authors declare no conflict of interest.

      Ethical approval

      All procedures performed in studies involving human participants were in accordance with the ethical standards and were approved by the Regional Ethical Committee, Harbin Medical University (Project Identification Code: HMUIRB2014012).

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      Yu, H., Zeng, X., Sui, M. et al. A head-to-head comparison of measurement properties of the EQ-5D-3L and EQ-5D-5L in acute myeloid leukemia patients. Qual Life Res 30, 855–866 (2021). https://doi.org/10.1007/s11136-020-02644-w

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      • DOI: https://doi.org/10.1007/s11136-020-02644-w

      Keywords

      • EQ-5D-3L
      • EQ-5D-5L
      • Measurement property
      • Acute myeloid leukemia
      • Cancer