Skip to main content

Advertisement

SpringerLink
Log in

Long-term health-related quality of life after surgery in patients with chronic thromboembolic pulmonary hypertension

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Purpose

To assess the dynamic of various health-related quality of life (HRQoL) parameters 3 years after pulmonary thromboendarterectomy (PTE), and to identify factors affecting HRQoL parameters in patients with chronic thromboembolic pulmonary hypertension (CTEPH) in the long-term follow-up after surgery.

Methods

This prospective cohort study included 128 patients with CTEPH before and after the PTE (3 year follow-up). The HRQoL was examined using the Short-Form 36 Health Survey Questionnaire (SF-36).

Results

In patients with CTEPH 3 years after PTE, a significant improvement in all the HRQoL parameters. The summary indicators of the physical and mental components of health remained at the same level as 1 year after the PTE and did not exceed 50 points. The residual pulmonary hypertension was a leading factor limiting parameters of physical and mental health 3 years after a PTE. In addition, the parameters of physical activity were adversely affected by age and the age-adjusted Charlson Comorbidity Index.

Conclusions

In the study group of patients with CTEPH, PTE contributes to a significant improvement in all HRQoL parameters, which observed both 1 year and 3 years after surgery. The leading factor adversely affecting the physical and emotional components of health in the long-term period after PTE was residual pulmonary hypertension recorded in the early postoperative period. In addition, some physical HRQoL parameters are affected by age and age-adjusted Charlson Comorbidity Index.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Jenkins, D. P., Madani, M., Mayer, E., Kerr, K., Kim, N., Klepetko, W., et al. (2012). Surgical treatment of chronic thromboembolic pulmonary hypertension. European Respiratory Journal,41(3), 735–742. https://doi.org/10.1183/09031936.000581.

    Article  PubMed  Google Scholar 

  2. Delcroix, M., Lang, I., Pepke-Zaba, J., Jansa, P., D’Armini, A. M., Snijder, R., et al. (2016). Long-term outcome of patients with chronic thromboembolic pulmonary hypertension. Circulation,133(9), 859–871. https://doi.org/10.1161/circulationaha.115.016522.

    Article  CAS  PubMed  Google Scholar 

  3. D’Armini, A. M., Cattadori, B., Monterosso, C., Klersy, C., Emmi, V., Piovella, F., et al. (2000). Pulmonary thromboendarterectomy in patients with chronic thromboembolic pulmonary hypertension: Hemodynamic characteristics and changes. European Journal of Cardio-Thoracic Surgery,18(6), 696–702. https://doi.org/10.1016/s1010-7940(00)00584-4.

    Article  PubMed  Google Scholar 

  4. Hoeper, M. M., Mayer, E., Simonneau, G., & Rubin, L. J. (2006). Chronic thromboembolic pulmonary hypertension. Circulation,113(16), 2011–2020. https://doi.org/10.1161/circulationaha.105.602565.

    Article  PubMed  Google Scholar 

  5. Yorke, J., Corris, P., Gaine, S., Gibbs, J. S. R., Kiely, D. G., Harries, C., et al. (2013). emPHasis-10: Development of a health-related quality of life measure in pulmonary hypertension. European Respiratory Journal,43(4), 1106–1113. https://doi.org/10.1183/09031936.00127113.

    Article  PubMed  Google Scholar 

  6. Mathai, S. C., Ghofrani, H.-A., Mayer, E., Pepke-Zaba, J., Nikkho, S., & Simonneau, G. (2016). Quality of life in patients with chronic thromboembolic pulmonary hypertension. European Respiratory Journal,48(2), 526–537. https://doi.org/10.1183/13993003.01626-2015.

    Article  PubMed  Google Scholar 

  7. Matura, L. A., McDonough, A., & Carroll, D. L. (2016). Symptom interference severity and health-related quality of life in pulmonary arterial hypertension. Journal of Pain and Symptom Management,51(1), 25–32. https://doi.org/10.1016/j.jpainsymman.2015.07.012.

    Article  PubMed  Google Scholar 

  8. Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., et al. (2015). ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. European Respiratory Journal,46(4), 903–975. https://doi.org/10.1183/13993003.01032-2015.

    Article  CAS  PubMed  Google Scholar 

  9. Delcroix, M., & Howard, L. (2015). Pulmonary arterial hypertension: The burden of disease and impact on quality of life. European Respiratory Review,24(138), 621–629. https://doi.org/10.1183/16000617.0063-2015.

    Article  PubMed  Google Scholar 

  10. McCollister, D. H., Beutz, M., McLaughlin, V., Rumsfeld, J., Masoudi, F. A., Tripputi, M., et al. (2010). Depressive symptoms in pulmonary arterial hypertension: Prevalence and association with functional status. Psychosomatics,51(4), 339–339. https://doi.org/10.1176/appi.psy.51.4.339.

    Article  PubMed  Google Scholar 

  11. Matura, L. A., McDonough, A., & Carroll, D. L. (2014). Health-related quality of life and psychological states in patients with pulmonary arterial hypertension. The Journal of Cardiovascular Nursing,29(2), 178–184. https://doi.org/10.1097/jcn.0b013e318275330d.

    Article  PubMed  Google Scholar 

  12. Freed, D. H., Thomson, B. M., Berman, M., Tsui, S. S. L., Dunning, J., Sheares, K. K., et al. (2011). Survival after pulmonary thromboendarterectomy: Effect of residual pulmonary hypertension. The Journal of Thoracic and Cardiovascular Surgery,141(2), 383–387. https://doi.org/10.1016/j.jtcvs.2009.12.056.

    Article  PubMed  Google Scholar 

  13. Auger, W. R., & Fedullo, P. F. (2015). Chronic thromboembolic pulmonary hypertension: Surgical treatment. PanVascular Medicine. https://doi.org/10.1007/978-3-642-37078-6_204.

    Article  Google Scholar 

  14. McGoon, M. D., Ferrari, P., Armstrong, I., Denis, M., Howard, L. S., Lowe, G., et al. (2019). The importance of patient perspectives in pulmonary hypertension. European Respiratory Journal,53(1), 1801919. https://doi.org/10.1183/13993003.01919-2018.

    Article  PubMed  Google Scholar 

  15. Kamenskaya, O., Klinkova, A., Loginova, I., Chernyavskiy, A., Lomivorotov, V. V., & Karaskov, A. (2017). Factors affecting the quality of life before and after surgery in patients with chronic thromboembolic pulmonary hypertension. Quality of Life Research,27(3), 747–754. https://doi.org/10.1007/s11136-017-1712-4.

    Article  PubMed  Google Scholar 

  16. Data processing instructions obtained by the SF-36 questionnaire. Electronic resource. Company Evidence – URL://https://therapy.irkutsk.ru/doc/sf36a.pdf (date of the application: 19.08.2014.

  17. Ware, J. E. (2000). SF-36 health survey update. Spine,25(24), 3130–3139. https://doi.org/10.1097/00007632-200012150-00008.

    Article  PubMed  Google Scholar 

  18. Degroot, V., Beckerman, H., Lankhorst, G., & Bouter, L. (2003). How to measure comorbiditya critical review of available methods. Journal of Clinical Epidemiology,56(3), 221–229. https://doi.org/10.1016/s0895-4356(02)00585-1.

    Article  Google Scholar 

  19. Jamieson, S. W., Kapelanski, D. P., Sakakibara, N., Manecke, G. R., Thistlethwaite, P. A., Kerr, K. M., et al. (2003). Pulmonary endarterectomy: Experience and lessons learned in 1,500 cases. The Annals of Thoracic Surgery,76(5), 1457–1464. https://doi.org/10.1016/s0003-4975(03)00828-2.

    Article  PubMed  Google Scholar 

  20. Kingman, M., Hinzmann, B., Sweet, O., & Vachiéry, J.-L. (2014). Living with pulmonary hypertension: Unique insights from an international ethnographic study. British Medical Journal Open,4(5), e004735. https://doi.org/10.1136/bmjopen-2013-004735.

    Article  Google Scholar 

  21. Jenkins, D. (2015). Pulmonary endarterectomy: The potentially curative treatment for patients with chronic thromboembolic pulmonary hypertension. European Respiratory Review,24(136), 263–271. https://doi.org/10.1183/16000617.00000815.

    Article  PubMed  Google Scholar 

  22. Corsico, A. G., D’Armini, A. M., Cerveri, I., Klersy, C., Ansaldo, E., Niniano, R., et al. (2008). Long-term outcome after pulmonary endarterectomy. American Journal of Respiratory and Critical Care Medicine,178(4), 419–424. https://doi.org/10.1164/rccm.200801-101oc.

    Article  PubMed  Google Scholar 

  23. Berman, M., Gopalan, D., Sharples, L., Screaton, N., Maccan, C., Sheares, K., et al. (2014). Right ventricular reverse remodeling after pulmonary endarterectomy: Magnetic resonance imaging and clinical and right heart catheterization assessment. Pulmonary Circulation,4(1), 36–44. https://doi.org/10.1086/674884.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Rahnavardi, M., Yan, T. D., Cao, C., Vallely, M. P., Bannon, P. G., & Wilson, M. K. (2011). Pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension : A systematic review. Annals of Thoracic and Cardiovascular Surgery,17(5), 435–445. https://doi.org/10.5761/atcs.oa.10.01653.

    Article  PubMed  Google Scholar 

  25. Schmitt-Opitz, I., & Ulrich, S. (2018). Chronic thromboembolic pulmonary hypertension. Swiss Medical Weekly. https://doi.org/10.4414/smw.2018.14702.

    Article  Google Scholar 

  26. Hsieh, W. C., Jansa, P., Huang, W. C., Nižnanský, M., Omara, M., & Lindner, J. (2018). Residual pulmonary hypertension after pulmonary endarterectomy: A meta-analysis. The Journal of Thoracic and Cardiovascular Surgery,156(3), 1275–1287. https://doi.org/10.1016/j.jtcvs.2018.04.110.

    Article  PubMed  Google Scholar 

  27. Cannon, J. E., Su, L., Kiely, D. G., Page, K., Toshner, M., Swietlik, E., et al. (2016). Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy. Circulation,133(18), 1761–1771. https://doi.org/10.1161/circulationaha.115.019470.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Kurfirst, V., Mokráček, A., Krupauerová, M., Čanádyová, J., Bulava, A., Pešl, L., et al. (2014). Health-related quality of life after cardiac surgery—The effects of age, preoperative conditions and postoperative complications. Journal of Cardiothoracic Surgery. https://doi.org/10.1186/1749-8090-9-46.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Jenkins, D., Madani, M., Fadel, E., D’Armini, A. M., & Mayer, E. (2017). Pulmonary endarterectomy in the management of chronic thromboembolic pulmonary hypertension. European Respiratory Review,26(143), 160111. https://doi.org/10.1183/16000617.0111-2016.

    Article  PubMed  Google Scholar 

  30. Perrotti, A., Ecarnot, F., Monaco, F., Dorigo, E., Monteleone, P., Besch, G., et al. (2019). Quality of life 10 years after cardiac surgery in adults: A long-term follow-up study. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-019-1160-7.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This study has no financial support or funding.

Author information

Authors and Affiliations

  1. Department of Physiology, E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, 630055, Russia

    Oksana Kamenskaya & Asya Klinkova

  2. Department of Cardiac Surgery, E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, 630055, Russia

    Aleksander Chernyavskiy & Alexander Edemskiy

  3. Department of Anesthesia and Intensive Care, E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Street, Novosibirsk, 630055, Russia

    Vladimir V. Lomivorotov & Vladimir Shmyrev

Authors
  1. Oksana Kamenskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Asya Klinkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Aleksander Chernyavskiy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vladimir V. Lomivorotov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alexander Edemskiy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Vladimir Shmyrev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Asya Klinkova.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kamenskaya, O., Klinkova, A., Chernyavskiy, A. et al. Long-term health-related quality of life after surgery in patients with chronic thromboembolic pulmonary hypertension. Qual Life Res 29, 2111–2118 (2020). https://doi.org/10.1007/s11136-020-02471-z

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-020-02471-z

Keywords

Search

Navigation