Advertisement

Quality of Life Research

, Volume 28, Issue 2, pp 297–319 | Cite as

Health state utility values measured using the EuroQol 5-dimensions questionnaire in adults with chronic hepatitis C: a systematic literature review and meta-analysis

  • A. M. Buchanan-HughesEmail author
  • M. Buti
  • K. Hanman
  • B. Langford
  • M. Wright
  • L. A. Eddowes
Article

Abstract

Purpose

Chronic hepatitis C infection and its treatment can considerably affect patients’ health-related quality-of-life (HRQoL). This study aimed to identify and summarise the current evidence base for health state utility values (HSUVs) in patients with chronic hepatitis C infection, generated using the EuroQol 5-dimensions (EQ-5D) questionnaire.

Methods

MEDLINE, Embase, the Cochrane Library and EconLit were searched from database inception through 31 August 2017. Eligible studies reported HSUVs elicited using the EQ-5D questionnaire in adults with chronic hepatitis C infection. Study quality and risk of bias were assessed.

Results

Of 1480 records identified, 26 studies were included. The most commonly defined health states described different stages of chronic hepatitis C infection and specific liver-related disease states, including METAVIR score, compensated and decompensated cirrhosis, hepatocellular carcinoma and liver transplantation. Patients with higher METAVIR scores tended to have lower EQ-5D scores compared to patients with lower METAVIR scores. Patients that achieved sustained virologic responses tended to have higher EQ-5D scores compared to those that did not. A meta-analysis conducted on three studies confirmed that patients with decompensated cirrhosis have significantly lower HSUVs than patients with compensated cirrhosis [mean difference − 0.11 (95% CI − 0.19 to − 0.04)], implying worse HRQoL. However, there was not sufficient evidence to compare how different treatments for chronic hepatitis C infection affect EQ-5D scores.

Conclusions

This study provides a summary of EQ-5D HSUVs for patients with chronic hepatitis C infection, and demonstrates that clinically important disease stages associated with treatment decisions are associated with differences in HRQoL.

Keywords

EQ-5D HCV Hepatitis C QoL Quality of life Utility 

Notes

Acknowledgements

ABH, KH, BL, LE and David Slater performed the abstract and full-text sifts. ABH, KH, LE and David Slater performed extractions of the included studies. BL performed the meta-analysis.

Funding

This study was funded by Gilead Sciences Europe Ltd.

Compliance with ethical standards

Conflict of interest

ABH, KH, BL and LE are employees of Costello Medical Consulting Ltd. David Slater was an employee at Costello Medical Consulting Ltd. at the time the SLR was conducted. MB has received research grants from Gilead, Merck Sharp & Dohme and AbbVie. MW has received speaker honoraria and participated in advisory boards for Gilead, AbbVie and Merck Sharp & Dohme.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.

Supplementary material

11136_2018_1992_MOESM1_ESM.docx (23 kb)
Supplementary material 1 (DOCX 23 KB)

References

  1. 1.
    World Health Organization (2018). Hepatitis C. http://www.who.int/mediacentre/factsheets/fs164/en/. Accessed July 19, 2018.
  2. 2.
    Negro, F., & Alberti, A. (2011). The global health burden of hepatitis C virus infection. Liver International, 31(s2), 1–3.CrossRefGoogle Scholar
  3. 3.
    Manns, M., Wedemeyer, H., & Cornberg, M. (2006). Treating viral hepatitis C: Efficacy, side effects, and complications. Gut, 55(9), 1350–1359.CrossRefGoogle Scholar
  4. 4.
    Seifert, L. L., Perumpail, R. B., & Ahmed, A. (2015). Update on hepatitis C: Direct-acting antivirals. World Journal of Hepatology, 7(28), 2829.CrossRefGoogle Scholar
  5. 5.
    Ermis, F., & Tasci, E. S. (2015). New treatment strategies for hepatitis C infection. World Journal of Hepatology, 7(17), 2100.CrossRefGoogle Scholar
  6. 6.
    Patrick, D. L., & Deyo, R. A. (1999). Generic and disease-specific measures in assessing health status and quality of life. Medical Care, 27, 217–232.CrossRefGoogle Scholar
  7. 7.
    Lawitz, E., Gane, E., Pearlman, B., Tam, E., Ghesquiere, W., Guyader, D., et al. (2015). Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): A randomised, open-label phase 2 trial. The Lancet, 385(9973), 1075–1086.CrossRefGoogle Scholar
  8. 8.
    European Medicines Agency (2005). Reflection Paper on the Regulatory Guidance for the Use of Health-Related Quality of Life (HRQL) Measures in the Evaluation of Medicinal Products, https://www.ispor.org/workpaper/emea-hrql-guidance.pdf. Accessed July 19, 2017.
  9. 9.
    Kastien-Hilka, T., Abulfathi, A., Rosenkranz, B., Bennett, B., Schwenkglenks, M., Sinanovic, E. (2016). Health-related quality of life and its association with medication adherence in active pulmonary tuberculosis—A systematic review of global literature with focus on South Africa. Health and Quality of Life Outcomes, 42(14), 1–13.Google Scholar
  10. 10.
    EuroQoL (2017). How to use EQ-5D. https://euroqol.org/eq-5d-instruments/. Accessed July 19, 2017.
  11. 11.
    National Institute of Health and Care Excellence (2013). Guide to the methods of technology appraisal 2013. https://www.nice.org.uk/process/pmg9/resources/guide-to-the-methods-of-technology-appraisal-2013-pdf-2007975843781. Accessed July 19, 2018.
  12. 12.
    Drummond, M. E., Sculpher, M. J., Torrance G. W., et al. (2005). Methods for the eocnomic evaluation of health care programmes (3rd ed.). Oxford: Oxford University Press.Google Scholar
  13. 13.
    Wee, H. L., Machin, D., Loke, W. C., Li, S. C., Cheung, Y. B., Luo, N., et al. (2007). Assessing differences in utility scores: A comparison of four widely used preference-based instruments. Value in Health, 10(4), 256–265.CrossRefGoogle Scholar
  14. 14.
    Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine, 151(4), 264–269.CrossRefGoogle Scholar
  15. 15.
    EuroQoL. (2017). Search engine for EuroQol and EQ-5D-related materialhttps://euroqol.org/. Accessed Sept 2017.
  16. 16.
    Papaioannou, D., Brazier, J., & Paisley, S. (2010). NICE DSU Technical Support Document 9: The identification, review and synthesis of health state utility values from the literature. https://www.ncbi.nlm.nih.gov/books/NBK425822/pdf/Bookshelf_NBK425822.pdf. Accessed 12 Sept 2018.
  17. 17.
    Chong, C. A. K. Y., Gulamhussein, A., Heathcote, E. J., Lilly, L., Sherman, M., Naglie, G., et al. (2003). Health-state utilities and quality of life in hepatitis C patients. American Journal of Gastroenterology, 98(3), 630–638.CrossRefGoogle Scholar
  18. 18.
    Bjornsson, E., Verbaan, H., Oksanen, A., Fryden, A., Johansson, J., Friberg, S., et al. (2009). Health-related quality of life in patients with different stages of liver disease induced by hepatitis C. Scandinavian Journal of Gastroenterology, 44(7), 878–887. [Multicenter Study]CrossRefGoogle Scholar
  19. 19.
    Samp, J. C., Perry, R., Piercy, J., & Baran, R. W. (2014). Utility values of hepatitis C patients in France: Results by liver disease stage and treatment outcome. Value in Health, 17(3), A279. [Conference Abstract]CrossRefGoogle Scholar
  20. 20.
    Samp, J. C., Perry, R., Piercy, J., Wood, R., & Baran, R. W. (2015). Patient health utility, work productivity, and lifestyle impairment in chronic hepatitis C patients in France. Clinics and Research in Hepatology and Gastroenterology, 39(3), 307–314.CrossRefGoogle Scholar
  21. 21.
    Custer, B., Vahidnia, F., Kessler, D., Leparc, G., Krysztof, D., Shaz, B., et al. (2014). Health-related quality of life in us blood donors with and without viral infections. Vox Sanguinis, 107, 97. [Conference Abstract]CrossRefGoogle Scholar
  22. 22.
    DeVecchis Wygant, G., Mo, L., Treitel, M., Bhore, R., & Torbeyns, A. (2016). EQ-5D results in Asian patients with HCV G1b receiving DCV + ASV who are IFN intolerant/ineligible. Hepatology International, 10(Suppl 1), S142.Google Scholar
  23. 23.
    Kaishima, T., Akita, T., Aikata, H., Chayama, K., & Tanaka, J. (2016). Cost-effectiveness analysis related to HCV treatment is possible to be estimated in each province. Hepatology International, 10(Suppl 1), S148–S149.Google Scholar
  24. 24.
    McDonald, S. A., Hutchinson, S. J., Palmateer, N. E., Allen, E., Cameron, S. O., Goldberg, D. J., et al. (2013). Decrease in health-related quality of life associated with awareness of hepatitis C virus infection among people who inject drugs in Scotland. Journal of Hepatology, 58(3), 460–466.CrossRefGoogle Scholar
  25. 25.
    Nouvertne, D., Perry, R., & Milligan, G. (2014). Health-related quality of life and productivity impairment in chronic hepatitis C patients in Germany. Journal of Viral Hepatitis, 21, 34–35. [Conference Abstract]Google Scholar
  26. 26.
    Pol, S., Chevalier, J., Branchoux, S., Perry, R., Milligan, G., & Gaudin, A. F. (2015). Health related quality of life and utility values in chronic hepatitis C patients: A cross-sectional study in France, the UK and Germany. Journal of Hepatology, 62, S606. [Conference Abstract]CrossRefGoogle Scholar
  27. 27.
    Nwankwo, C. U., Sung, A. H., & Pike, J. S. (2014). Self-reported health related quality of life of hepatitis C virus (HCV) genotype 1 patients with and without comorbid conditions. Value in Health, 17(7), A369–A370.CrossRefGoogle Scholar
  28. 28.
    Schafer, A., Wittchen, H. U., Backmund, M., Soyka, M., Golz, J., Siegert, J., et al. (2009). Psychopathological changes and quality of life in hepatitis C virus-infected, opioid-dependent patients during maintenance therapy. Addiction, 104(4), 630–640.CrossRefGoogle Scholar
  29. 29.
    Scalone, L., Ciampichini, R., Fagiuoli, S., Gardini, I., Fusco, F., Gaeta, L., et al. (2013). Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases. Quality of Life Research, 22(7), 1707–1716.CrossRefGoogle Scholar
  30. 30.
    Schwarzinger, M., Cossais, S., Deuffic-Burban, S., Pol, S., Fontaine, H., Larrey, D., et al. (2015). EQ-5D utility index in French patients with chronic hepatitis C (CHC) infection: Severe comorbidities and perceived progression of CHC infection matter more than actual liver disease stage. Journal of Hepatology, 62, S605.CrossRefGoogle Scholar
  31. 31.
    Scott, J., Rosa, K., Fu, M., Cerri, K., Peeters, M., Beumont, M., et al. (2014). Fatigue during treatment for hepatitis C virus: Results of self-reported fatigue severity in two Phase IIb studies of simeprevir treatment in patients with hepatitis C virus genotype 1 infection. BMC Infectious Diseases, 14(1), 465.CrossRefGoogle Scholar
  32. 32.
    Stepanova, M., Nader, F., Cure, S., Bourhis, F., Hunt, S., & Younossi, Z. M. (2014). Patients’ preferences and health utility assessment with SF-6D and EQ-5D in patients with chronic hepatitis C treated with sofosbuvir regimens. Alimentary Pharmacology and Therapeutics, 40(6), 676–685.CrossRefGoogle Scholar
  33. 33.
    Younossi, Z. M., Stepanova, M., Cure, S., Bourhis, F., Nader, F., & Hunt, S. L. (2014). Estimating health status using EQ5D for chronic hepatitis c (CH-C) patients treated with sofosbuvir (SOF) containing regimens. Journal of Hepatology, 1, S308. [Conference Abstract]Google Scholar
  34. 34.
    Vargas, C. L., Espinoza, M. A., Giglio, A., & Soza, A. (2015). Cost effectiveness of daclatasvir/asunaprevir versus peginterferon/ribavirin and protease inhibitors for the treatment of hepatitis c genotype 1b Naive patients in Chile. PLoS ONE. 10(11), e0141660.CrossRefGoogle Scholar
  35. 35.
    Vera-Llonch, M., Martin, M., Aggarwal, J., Donepudi, M., Bayliss, M., Goss, T., et al. (2013). Health-related quality of life in genotype 1 treatment-naive chronic hepatitis C patients receiving telaprevir combination treatment in the ADVANCE study. Alimentary Pharmacology and Therapeutics, 38(2), 124–133.CrossRefGoogle Scholar
  36. 36.
    Yeung, M. W., Young, J., Moodie, E., Rollet-Kurhajec, K. C., Schwartzman, K., Greenaway, C., et al. (2015). Changes in quality of life, healthcare use, and substance use in HIV/hepatitis C coinfected patients after hepatitis C therapy: A prospective cohort study. HIV Clinical Trials, 16(3), 100–110.CrossRefGoogle Scholar
  37. 37.
    Wright, M., & Grieve, R. (2006). Health benefits of antiviral therapy for mild chronic hepatitis C: Randomised controlled trial and economic evaluation. (Provisional abstract). Health Technology Assessment. 10, 1–250.CrossRefGoogle Scholar
  38. 38.
    Vahidnia, F., Stramer, S. L., Kessler, D., Shaz, B., Leparc, G., Krysztof, D. E., et al. (2017). Recent viral infection in US blood donors and health-related quality of life (HRQOL). Quality of Life Research, 26(2), 349–357.CrossRefGoogle Scholar
  39. 39.
    Gschwantler, M., Ferenci, P., Bauer, B., Laferl, H., Bamberger, T., Stauber, R., et al. (2016). Burden of disease in patients with chronic hepatitis C in the Austrian REAL Study. Hepatology, 63(Suppl 1), 466a–467a. [Journal: Conference Abstract]Google Scholar
  40. 40.
    Huang, R., Rao, H., & Wei, L. (2017). Assessment of health-related quality of life and related factors in Chinese patients with chronic hepatitis C virus infection. Hepatology International, 11(Suppl 1), S558. [Conference Abstract]Google Scholar
  41. 41.
    Kieran, J. A., Adams, R., Chin, J. L., Mushtaq, H., McCormick, P. A., McKiernan, S., et al. (2015). Health-state utilities for patients with chronic Hepatitis C infection. Irish Journal of Medical Science, 184(6 Suppl 1), S230. [Conference Abstract]Google Scholar
  42. 42.
    Wygant, G., Mo, L., Treitel, M., & Zhao, Y. (2017). Patient reported outcomes in IFN/ribavirin intolerant/ineligible Asian patients from Mainland China receiving daclatasvir + asunaprevir for the treatment of HCV genotype 1b infection. Hepatology International, 11(Suppl 1), S1001–S1002. [Conference Abstract]Google Scholar
  43. 43.
    MVH Group (1995). The measurement and valuation of health: Final report on the modelling of valuation tariffs. York: Centre for Health Economics, University of York.Google Scholar
  44. 44.
    Badia, X., Roset, M., Herdman, M., & Kind, P. (2001). A comparison of United Kingdom and Spanish general population time trade-off values for EQ-5D health states. Medical Decision Making, 21(1), 7–16.CrossRefGoogle Scholar
  45. 45.
    ClinicalTrials.gov (2017). NCT01542788 (POSITRON). https://clinicaltrials.gov/ct2/show/NCT01542788. Accessed July 19, 2018.
  46. 46.
    ClinicalTrials.gov (2017). NCT01497366 (FISSION). https://clinicaltrials.gov/ct2/show/NCT01497366. Accessed July 19, 2018.
  47. 47.
    ClinicalTrials.gov (2017). NCT01604850 (FUSION). https://clinicaltrials.gov/ct2/show/NCT01604850. Accessed July 19, 2018.
  48. 48.
    ClinicalTrials.gov (2017). NCT01641640 (NEUTRINO). https://clinicaltrials.gov/ct2/show/NCT01641640. Accessed July 19, 2018.
  49. 49.
    Ara, R., & Brazier, J. (2008). Deriving an algorithm to convert the eight mean SF-36 dimension scores into a mean EQ-5D preference-based score from published studies (where patient level data are not available). Value in Health, 11(7), 1131–1143.CrossRefGoogle Scholar
  50. 50.
    Richardson, J., Iezzi, A., Khan, M. A., & Maxwell, A. (2012). Cross-national comparison of twelve quality of life instruments. MIC Paper, 2. https://www.aqol.com.au/papers/researchpaper78.pdf. Accessed 12 Sept 2018.
  51. 51.
    Rowen, D., Brazier, J., Tsuchiya, A., & Alava, M. H. (2012). Valuing states from multiple measures on the same visual analogue sale: A feasibility study. Health Economics, 21(6), 715–729.CrossRefGoogle Scholar
  52. 52.
    Gray, A., Clarke, P., & Rivero-Arias, O. (2004). Estimating the association between SF-36 responses and EQ-5D utility values by direct mapping. In Health Economists Studying Group Meeting (HESG), Paris.Google Scholar
  53. 53.
    Shaw, J. W., Johnson, J. A., & Coons, S. J. (2005). US valuation of the EQ-5D health states: Development and testing of the D1 valuation model. Medical Care, 43, 203–220.CrossRefGoogle Scholar
  54. 54.
    Zarate, V., Kind, P., Valenzuela, P., Vignau, A., Olivares-Tirado, P., & Munoz, A. (2011). Social valuation of EQ-5D health states: The Chilean case. Value in Health, 14(8), 1135–1141.CrossRefGoogle Scholar
  55. 55.
    Fryback, D. G., Dunham, N. C., Palta, M., Hanmer, J., Buechner, J., Cherepanov, D., et al. (2007). US norms for six generic health-related quality-of-life indexes from the National Health Measurement Study. Medical Care, 45(12), 1162.CrossRefGoogle Scholar
  56. 56.
    Dolan, P., Gudex, C., Kind, P., & Williams, A. (1995). A social tariff for EuroQol: Results from a UK general population survey. York: Centre for Health Economics University of York.Google Scholar
  57. 57.
    Longworth, L., Young, T., Ratcliffe, J., Bryan, S., & Buxton, M. (2001) Economic evaluation of the Transplantation Programme in England and Wales: An assessment of the costs of liver transplantation. Report to the Department of Health.Google Scholar
  58. 58.
    Bansback, N., Tsuchiya, A., Brazier, J., & Anis, A. (2012). Canadian valuation of EQ-5D health states: Preliminary value set and considerations for future valuation studies. PLoS ONE, 7(2), e31115.CrossRefGoogle Scholar
  59. 59.
    Peasgood, T., & Brazier, J. (2015). Is meta-analysis for utility values appropriate given the potential impact different elicitation methods have on values? Pharmacoeconomics, 33(11), 1101–1105.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • A. M. Buchanan-Hughes
    • 1
    Email author
  • M. Buti
    • 2
    • 3
  • K. Hanman
    • 1
  • B. Langford
    • 1
  • M. Wright
    • 4
  • L. A. Eddowes
    • 1
  1. 1.Costello Medical Consulting LtdCambridgeUK
  2. 2.Hospital Universitario Valle HebronBarcelonaSpain
  3. 3.Ciberehd del Instituto Carlos IIIMadridSpain
  4. 4.University Hospital Southampton NHS Foundation TrustSouthamptonUK

Personalised recommendations