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Methamphetamine use and oral health-related quality of life

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Methamphetamine (MA) is associated with adverse health effects, including the rampant tooth decay condition called “Meth Mouth.” However, the impact of MA use on oral health-related quality of life (OHRQOL) is unknown. This study assessed the relationship between MA use and self-reported OHRQOL.


This cross-sectional study uses information from 545 MA-using participants recruited from Los Angeles County, California. Dental examinations were performed by three calibrated dentists using National Health and Nutrition Examination Survey (NHANES) protocols. Data on socio-demographic, behavioral, and drug-use history were recorded using questionnaires. Participants were categorized as ‘light’ or ‘moderate/heavy’ users based on reported frequency of MA use in the past 30 days. Route of MA administration was categorized as ‘smoking’ or ‘other.’ Self-reported OHRQOL was based on the Oral Health Impact Profile scale.


Majority of the participants were male (80.9%). Median age was 45.0 years (IQR-13.0). Median number of days of MA use was 10.0 (IQR-12.0). Smoking was the preferred route of MA use (70.2%). Root caries in ≥ 3 teeth were reported in 78% of MA users. More than half of the participants reported having painful aching in mouth, avoidance of particular food items, feeling embarrassed, and discomfort while eating in the last 12 months. In unadjusted logistic models, moderate/heavy MA users were more likely to report an affected sense of taste [OR = 1.58, 95% CI (1.10–2.27)] and avoidance of particular foods [OR = 1.45, 95% CI (1.02–2.01)] than light users. Among individuals preferring other MA administration routes, moderate/heavy MA users were 3.09 times as likely to report an affected sense of taste than light users [OR = 3.09, 95% CI (1.52−6.27)].


Oral health and OHRQOL appear to be worse among Methamphetamine users than in the US general population.

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  1. NIDA (2018). Methamphetamine. 2018, June 6 [cited 2018 June 26]; Retrieved from

  2. Baumgarten, H. G., & Lachenmayer, L. (2004). Serotonin neurotoxins–past and present. Neurotox Research, 6(7–8), 589–614.

    Article  CAS  Google Scholar 

  3. Cadet, J. L., Jayanthi, S., & Deng, X. (2003). Speed kills: Cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 17(13), 1775–1788.

    Article  CAS  Google Scholar 

  4. Itzhak, Y., & Achat-Mendes, C. (2004). Methamphetamine and MDMA (ecstasy) neurotoxicity: ‘of mice and men’. IUBMB Life, 56(5), 249–255.

    Article  CAS  Google Scholar 

  5. Sulzer, D., et al. (2005). Mechanisms of neurotransmitter release by amphetamines: A review. Prog Neurobiol, 75(6), 406–433.

    Article  CAS  Google Scholar 

  6. NSDUH (2016). 2016 National Survey on Drug Use and Health: Detailed Tables. Substance Abuse and Mental Health Services Administration. 2017 June 6, 2018.]; Retrieved from

  7. Klasser, G. D., & Epstein, J. (2005). Methamphetamine and its impact on dental care. J Can Dent Assoc, 71(10), 759–762.

    PubMed  Google Scholar 

  8. Beebe, D. K., & Walley, E. (1995). Smokable methamphetamine (‘ice’): An old drug in a different form. American Family Physician, 51(2), 449–453.

    CAS  PubMed  Google Scholar 

  9. Yu, Q., Larson, D. F., & Watson, R. R. (2003). Heart disease, methamphetamine and AIDS. Life Science, 73(2), 129–140.

    Article  CAS  Google Scholar 

  10. Shetty, V., et al. (2015). Dental disease patterns in methamphetamine users: Findings in a large urban sample. Journal of the American Dental Association, 146(12), 875–885.

    Article  Google Scholar 

  11. Communications, & ADADo, Journal of the American Dental Association, Affairs ADADoS (2005). For the dental patient … methamphetamine use and oral health. Journal of the American Dental Association, 136(10), 1491.

    Article  Google Scholar 

  12. Shaner, J. W. (2002). Caries associated with methamphetamine abuse. Journal Michigan Dental Association, 84(9), 42–47.

    Google Scholar 

  13. McGrath, C., & Chan, B. (2005). Oral health sensations associated with illicit drug abuse. British Dental Journal, 198(3): p. 159 – 62; dicussion 147; quiz 174.

    Article  CAS  Google Scholar 

  14. Morio, K. A., et al. (2008). Comparing diet, oral hygiene and caries status of adult methamphetamine users and nonusers: A pilot study. Journal of the American Dental Association, 139(2), 171–176.

    Article  Google Scholar 

  15. Shetty, V., et al. (2010). The relationship between methamphetamine use and increased dental disease. Journal of the American Dental Association, 141(3), 307–318.

    Article  Google Scholar 

  16. Ravenel, M. C., et al. (2012). Methamphetamine abuse and oral health: A pilot study of “meth mouth”. Quintessence International, 43(3), 229–237.

    PubMed  Google Scholar 

  17. Rommel, N., et al. (2016). The impact of the new scene drug “crystal meth” on oral health: A case-control study. Clinical Oral Investigations, 20(3), 469–475.

    Article  Google Scholar 

  18. Boyer, E. M., et al. (2015). The relationship between methamphetamine use and dental caries and missing teeth. The Journal of Dental Hygiene, 89(2), 119–131.

    PubMed  Google Scholar 

  19. Smit, D. A., & Naidoo, S. (2015). Oral health effects, brushing habits and management of methamphetamine users for the general dental practitioner. British Dental Journal, 218(9), 531–536.

    Article  CAS  Google Scholar 

  20. Truong, A., et al. (2015). Oral health-related quality of life among an Australian sample of people who inject drugs. Journal of Public Health Dentistry, 75(3), 218–224.

    Article  Google Scholar 

  21. Inglehart, M. R. (2002). Oral Health-Related Quality of Life. Oral health-related quality of life: An introduction, (p. 244). Chicago, IL: Quintessence Publishing.

    Google Scholar 

  22. USHHS (2000). Oral Health in America: A Report of the Surgeon General. 2000 [cited 2016 December 30]; Retrieved from

  23. Dye, B. A., et al. (2015). Performance of a quality assurance program for assessing dental health in methamphetamine users. BMC Oral Health, 15, 76.

    Article  Google Scholar 

  24. Slade., G. (1997). Derivation and validation of a short-form oral health impact profile. Community Dentistry and Oral Epidemiology, 25(4), 284–290.

    Article  CAS  Google Scholar 

  25. Sanders, A. E., et al. (2009). Impact of oral disease on quality of life in the US and Australian populations. Community Dentistry and Oral Epidemiology, 37(2), 171–181.

    Article  Google Scholar 

  26. Eke, P. I., et al. (2012). Update of the case definitions for population-based surveillance of periodontitis. Journal of Periodontology, 83(12), 1449–1454.

    Article  Google Scholar 

  27. Gonzales, R., et al. (2011). Quality of life among treatment seeking methamphetamine-dependent individuals. The American Journal on Addictions, 20(4), 366–372.

    Article  Google Scholar 

  28. Seirawan, H., Sundaresan, S., & Mulligan, R. (2011). Oral health-related quality of life and perceived dental needs in the United States. Journal of Public Health Dentistry, 71(3), 194–201.

    PubMed  Google Scholar 

  29. Gonzales, R., et al. (2009). Health-related quality of life trajectories of methamphetamine-dependent individuals as a function of treatment completion and continued care over a 1-year period. The Journal of Substance Abuse Treatment, 37(4), 353–361.

    Article  Google Scholar 

  30. McLellan, A. T., et al. (2000). Drug dependence, a chronic medical illness: Implications for treatment, insurance, and outcomes evaluation. JAMA, 284(13), 1689–1695.

    Article  CAS  Google Scholar 

  31. Jones, D. R., et al. (2004). Prevalence, severity, and co-occurrence of chronic physical health problems of persons with serious mental illness. Psychiatric Services, 55(11), 1250–1257.

    Article  Google Scholar 

  32. Sischo, L., & Broder, H. L. (2011). Oral health-related quality of life: What, why, how, and future implications. Journal of Dental Research, 90(11), 1264–1270.

    Article  CAS  Google Scholar 

  33. Kim, J. K., et al. (2012). Prevalence of oral health problems in U.S. adults, NHANES 1999–2004: Exploring differences by age, education, and race/ethnicity. Special Care Dentistry, 32(6), 234–241.

    Article  Google Scholar 

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Parent study Grant Number: R01 DA025680. Granting agency: National Institute on Drug Abuse, National Institutes of Health (Recipient: Dr. Vivek Shetty).

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Correspondence to Bruce A. Dye.

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The authors declare they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Mukherjee, A., Dye, B.A., Clague, J. et al. Methamphetamine use and oral health-related quality of life. Qual Life Res 27, 3179–3190 (2018).

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