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Comparison between the EQ-5D-5L and the EQ-5D-3L in patients with hepatitis B

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Abstract

Objectives

The purpose of the study was to compare psychometric properties of the EQ-5D-5L (5L) and the EQ-5D-3L (3L) health outcomes assessment instruments in patients with hepatitis B in China.

Methods

Patients, including hepatitis B virus carriers and those with active or inactive chronic hepatitis B, compensated cirrhosis, decompensated cirrhosis or hepatocellular carcinoma, answered a questionnaire composed of 5L, socio-demographic information, 3L, and the visual analog scale (VAS), respectively. After 1 week, a retest was conducted for inpatients. We compared acceptability, face validity, redistribution properties, convergent validity, known-group validity, discriminatory power, ceiling effect, test–retest reliability, and responsiveness of 5L and 3L.

Results

A total of 369 outpatients and 276 inpatients were recruited for the first interview. Of the inpatients, 183 were used in the retest. Most patients preferred 5L–3L. The 3L–5L response pairs had an inconsistency rate of 2.4 %. Correlation with the VAS was greater with 5L than with 3L. Age, education, and comorbidity were associated with health-related quality of life (HRQoL). 5L discriminated more infectious conditions than 3L. In all dimensions, the Shannon’s index from 5L was larger while in three dimensions the Shannon’s evenness index from 5L was slightly larger. The ceiling effect was reduced in 5L. In patients with stable health states, no significant difference was detected in the weighted kappa between 5L and 3L, but intraclass correlation coefficient of 5L was higher than that of 3L. In patients with improved health states, HRQoL was seen as increased in both 5L and 3L, without significant difference.

Conclusions

The EQ-5D-5L was more suitable than the EQ-5D-3L in the patients with hepatitis B in China.

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Acknowledgments

The use of two versions of EQ-5D was approved by EuroQol Group. This study was sponsored by National Health and Family Planning Commission and Minister of Science and Technology (No.2012ZX10002001), and we would like to express the special thanks to Rodewald Lance, who provided comments and suggestions on the manuscript.

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Authors and Affiliations

  1. National Immunization Program, Chinese Center for Disease Control and Prevention, Nanwei Road, Xicheng District, Beijing, China

    Y. X. Jia, F. Q. Cui, L. Li, G. M Zhang, F. Z. Wang, X. H. Gong, H. Zheng, Z. H. Wu, N. Miao & X. J. Sun

  2. Ningbo Center for Disease Control and Prevention, Ningbo, China

    D. L. Zhang

  3. Shandong Center for Disease Control and Prevention, Jinan, China

    L. Zhang & J. J. Lv

  4. Qingdao Center for Disease Control and Prevention, Qingdao, China

    F. Yang

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  1. Y. X. Jia
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  2. F. Q. Cui
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  3. L. Li
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  4. D. L. Zhang
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  5. G. M Zhang
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  12. L. Zhang
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Corresponding author

Correspondence to F. Q. Cui.

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Jia, Y.X., Cui, F.Q., Li, L. et al. Comparison between the EQ-5D-5L and the EQ-5D-3L in patients with hepatitis B. Qual Life Res 23, 2355–2363 (2014). https://doi.org/10.1007/s11136-014-0670-3

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  • DOI: https://doi.org/10.1007/s11136-014-0670-3

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