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Quality of Life Research

, Volume 22, Issue 8, pp 1943–1954 | Cite as

Validation of a new quality of life scale related to multiple sclerosis and relapses

  • Antoine Baroin
  • Gilles Chopard
  • Gaye Siliman
  • Clément Michoudet
  • Aurore Vivot
  • Chrystelle Vidal
  • Hassna Mokadym
  • Annick Lavier
  • Ėric Berger
  • Lucien Rumbach
  • Nathalie Rude
Article

Abstract

Purpose

Multiple sclerosis (MS) has a significant impact on all aspects of patient quality of life (QoL). Furthermore, the fear of relapses and the feelings of patients during relapses must be taken into account in care. The objective of this work was to validate the PERSEPP scale (“PERception de la Sclérose En Plaques et de ses Poussées”), a new QoL evaluation scale for relapsing–remitting forms of MS.

Methods

Relapsing–remitting patients were included in a multicenter study. Various validation criteria of this scale were analyzed: acceptability, construct validity (internal and external validity), and reliability (internal consistency and reproducibility test–retest). Responsiveness will be studied in order to complete the validation process.

Results

The responses of 305 MS patients were analyzed. The process of reducing the items led us to retain 66 items of a total of 112 items. The 66-item PERSEPP scale (final version) was well accepted. Five dimensions (33 items) make up the scale: social support (α = 0.81), relationship difficulties (α = 0.71), fatigue (α = 0.74), state of mind and associated sleep disorders (α = 0.78), and time perspective (α = 0.75). Three additional modules (33 items) explore coping (α = 0.60), symptoms (α = 0.89), and treatment (α = 0.92). Test–retest reliability, measured by the intraclass correlation coefficient (ICC), was acceptable (0.72 < ICC < 0.92).

Conclusions

The PERSEPP scale has been validated and could be used in clinical trials and in daily practice. Additional studies will then complete the validation process.

Keywords

Multiple sclerosis Health-related quality of life Relapsing–remitting form Validation PERSEPP scale 

Notes

Acknowledgments

We would like to thank the Ligue Française contre la Sclérose En Plaques (LFSEP) and the AGIRSEP group, as well as Franck Leroux and Frances Sheppard (Clinical Investigation Center: Inserm CIT 808, Besançon) for their participation in this project. Co-investigators: Marc Debouverie, Sophie Pittion-Vouyovitch (Nancy), Thibault Moreau (Dijon), Jérôme de Sèze, Marie-Céline Fleury (Strasbourg), Pierre Clavelou, Dominique Aufauvre (Clermont-Ferrand), François Ziegler (Belfort), Christine Clerc (Montbéliard), Constantino Gomes (Lons-le-Saunier), Annabelle Jary (Vesoul), Olivier Heinzlef (Poissy). Private practice neurologists: Jean Galmiche (Besançon), Claudine Portha (Besançon), Didier Chavot (Besançon), Claire Sevrin (Besançon), Philippe Sevrin (Besançon), Valérie Martin-Clair (Besançon), Véronique Seyeux (Pontarlier), Pascale Labouret (Belfort), Christophe Zaenker (Colmar). The study was funded by the Ligue française contre la sclérose en plaques (LFSEP) and the Agirsep group.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Antoine Baroin
    • 1
    • 2
  • Gilles Chopard
    • 1
    • 2
  • Gaye Siliman
    • 4
  • Clément Michoudet
    • 4
  • Aurore Vivot
    • 4
  • Chrystelle Vidal
    • 4
  • Hassna Mokadym
    • 2
  • Annick Lavier
    • 1
    • 4
  • Ėric Berger
    • 1
  • Lucien Rumbach
    • 1
    • 3
    • 4
  • Nathalie Rude
    • 2
  1. 1.Department of NeurologyBesançon University HospitalBesançon CedexFrance
  2. 2.Laboratory of Neurosciences, EA 481University of Franche-ComtéBesançonFrance
  3. 3.Laboratory of Imagery and Cognitive NeurosciencesUMR 7237, University of StrasbourgStrasbourgFrance
  4. 4.Clinical Investigation Center in Technological Innovation (Inserm CIC-IT 808)Besançon University HospitalBesançonFrance

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