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Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases

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Abstract

Purpose

To assess the performance of the EQ-5D-5L version compared with the standard EQ-5D-3L in a clinical setting targeted at patients with chronic hepatic diseases (CHDs).

Methods

We introduced the 5L descriptive system into a cost-of-illness study involving patients with different CHDs. The patients completed a questionnaire including the two versions of the EQ-5D, together with other questions related to their condition. We tested the feasibility, the level of inconsistency, the redistribution properties among consistent responses, the ceiling effect, the discriminative power, and the convergent validity of the 5L compared with the 3L system.

Results

A total of 1,088 valid patients were recruited: 62 % male, 19–89 (median = 59) years old. Patients had chronic hepatitis from HCV (31.8 %) or HBV infections (29.3 %) or other causes (7.8 %), 20.4 % had cirrhosis, 11.9 % underwent liver transplantation, and 7.8 % had hepatic carcinoma. Less than 1 % of EQ-5D-5L were returned blank, and 1.6 % or less of missing values were calculated on the dimensions of the partially completed questionnaires. The proportion and weight of inconsistent responses (i.e., 3L responses that were at least two levels away from the 5L responses) was 2.9 % and 1.2 on average, respectively. Regarding redistribution, 57–65 % of the patients answering level 2 with the 3L version redistributed their responses to levels 2 or 4 with the 5L version. A relative 7 % reduction of the ceiling effect was found. Furthermore, the absolute informativity increased but the relative informativity slightly decreased in every domain, and the convergent validity with the VAS improved.

Conclusions

In a clinical setting involving CHD patients, the EQ-5D-5L was shown to be feasible and with promising levels of performance. Our findings suggest that the 5L performs better in at least some of the properties analyzed, and encourage further research to also test other psychometric properties of this new version of the EQ-5D.

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Acknowledgments

Thanks to Anna Baldan and Giulia Magini, who cooperated in drafting the questionnaire, and to Giovanna Gaffuri for her contribute during data collection. Funds were provided by EpaC Onlus Patients Associations and CHARTA Foundation

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Authors and Affiliations

  1. CESP, Research Centre on Public Health, University of Milano Bicocca, Milan, Italy

    Luciana Scalone & Giancarlo Cesana

  2. CHARTA Foundation, Milan, Italy

    Luciana Scalone, Roberta Ciampichini, Francesco Fusco & Lorenzo G. Mantovani

  3. Ospedali Riuniti, Bergamo, Italy

    Stefano Fagiuoli, Laura Gaeta & Anna Del Prete

  4. Patients’ Organization—EpaC ONLUS, Milan, Italy

    Ivan Gardini

  5. CIRFF, Centre of Pharmacoeconomics, University of Naples Federico II, Naples, Italy

    Lorenzo G. Mantovani

  6. Fondazione Charta, Via Visconti di Modrone, 18, 20122, Milan, Italy

    Luciana Scalone

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  1. Luciana Scalone
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  2. Roberta Ciampichini
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  3. Stefano Fagiuoli
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  4. Ivan Gardini
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  5. Francesco Fusco
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  6. Laura Gaeta
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  7. Anna Del Prete
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  8. Giancarlo Cesana
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  9. Lorenzo G. Mantovani
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Correspondence to Luciana Scalone.

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Scalone, L., Ciampichini, R., Fagiuoli, S. et al. Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases. Qual Life Res 22, 1707–1716 (2013). https://doi.org/10.1007/s11136-012-0318-0

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  • DOI: https://doi.org/10.1007/s11136-012-0318-0

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