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The impact of persistent visually disabling vitreous floaters on health status utility values

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Abstract

Purpose

To assess the time trade-off (TTO) utility values in patients with persistent visually disabling vitreous floaters (DVF) and to determine the reliability and validity of TTO methods in DVF patients.

Methods

Prospective cross-sectional questionnaire survey: Eligible patients with persistent DVF referred to the Shanghai First People’s Hospital outpatient service between January 2006 and February 2010, and randomly selected normal vision general population residents, were enrolled. All participants underwent TTO utility value evaluation. After 4–5 weeks, the patients were asked to undergo second TTO utility value evaluation during the follow-up interview.

Results

The mean initial utility values of the 107 persistent DVF patients were 0.904 ± 0.054. Regression analyses revealed that length of education, visual acuity in the poorer-vision eye and employment status were associated with utility values (all P < 0.01). All patients took part in the follow-up interview; the intra-class correlation coefficient for TTO utility values at the initial and follow-up interviews was 0.855. In the 91 general population residents, the mean utility value was 0.923 ± 0.032, which was statistically higher than that of active study patients (t = 3.01, P < 0.01).

Conclusions

Persistent DVF can substantially diminish the patients’ perception of their life, and can be measured by TTO utility values with high reliability and construct validity.

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Abbreviations

ANOVA:

One-way analysis of variance

BCVA:

Best corrected visual acuity

CIs:

Confidence intervals

DVF:

Disabling vitreous floaters

ICC:

Intra-class correlation coefficient

SDs:

Standard deviations

TTO:

Time trade-off

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Acknowledgments

Shanghai Medical Bureau and Hong Kong K.C. Wong Education foundation are acknowledged for supporting this study with grants.

Conflict of interest

None of the authors have any financial interests to disclose. None of the authors have proprietary interest.

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Correspondence to Haidong Zou.

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Zou, H., Liu, H., Xu, X. et al. The impact of persistent visually disabling vitreous floaters on health status utility values. Qual Life Res 22, 1507–1514 (2013). https://doi.org/10.1007/s11136-012-0256-x

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  • DOI: https://doi.org/10.1007/s11136-012-0256-x

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