Skip to main content

Advertisement

SpringerLink
Log in

Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Purpose

Association of Metabolic Syndrome (MetS) with Health-Related Quality of Life (HRQoL) is poorly documented. Our objective was to examine this association in an adult general population.

Methods

In our cross-sectional community-based health survey in a semirural Finnish community, we invited all the adults (n = 760) of eight birth cohorts between 30 and 65 years, of which 480 (63%) participated. A 15-dimensional, standardized HRQoL instrument (15D) was used to measure the main outcome, and the National Cholesterol Education Programme (NCEP) 2005 criteria were used for MetS classification.

Results

The prevalence of MetS was 38%. MetS was significantly associated with impaired HRQoL (P < 0.001) measured by the 15D score. Participants with MetS were statistically significantly worse off than participants without MetS in the dimensions of mobility (P < 0.001), hearing (P = 0.021), breathing (P < 0.001), usual activities (P = 0.001), discomfort and symptoms (P = 0.002), vitality (P = 0.003), and sexual activity (P = 0.008). In a logistic regression analysis, a significant association persisted between MetS and impaired HRQoL (OR = 1.9).

Conclusions

MetS seems to be associated closely with perceived HRQoL at community level. Therefore, reduction of risk factors of MetS may improve HRQoL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

15D:

15-Dimensional instrument for measuring health-related quality of life

BMI:

Body mass index

DEHKO:

Development programme for the prevention and care of diabetes in Finland

HRQoL:

Health-related quality of life

IDF:

International Diabetes Federation

LRA:

Logistic regression analysis

MetS:

Metabolic syndrome

MID:

Minimal clinically important difference

NCEP:

National Cholesterol Education Programme

References

  1. Reaven, G. M. (1988). Banting lecture 1988: Role of insulin resistance in human disease. Diabetes, 37, 1595–1607. doi:10.2337/diabetes.37.12.1595.

    Article  PubMed  CAS  Google Scholar 

  2. Eckel, R. H., Grundy, S. M., & Zimmet, P. Z. (2005). The Metabolic Syndrome. Lancet, 365, 1415–1428. doi:10.1016/S0140-6736(05)66378-7.

    Article  PubMed  CAS  Google Scholar 

  3. Laaksonen, D. E., Lakka, H. M., Niskanen, L. K., Kaplan, G. A., Salonen, J. T., & Lakka, T. A. (2002). Metabolic syndrome and development of diabetes mellitus: Application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. American Journal of Epidemiology, 156, 1070–1077. doi:10.1093/aje/kwf145.

    Article  PubMed  Google Scholar 

  4. Facchini, F. S., Hua, N., Abbasi, F., & Reaven, G. M. (2001). Insulin resistance as a predictor of age-related diseases. The Journal of Clinical Endocrinology and Metabolism, 86, 3574–3578. doi:10.1210/jc.86.8.3574.

    Article  PubMed  CAS  Google Scholar 

  5. Lakka, H.-M., Laaksonen, D. E., Lakka, T. A., Niskanen, L. K., Kumpusalo, E., Tuomilehto, J., et al. (2002). The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Journal of the American Medical Association, 288, 2709–2716. doi:10.1001/jama.288.21.2709.

    Article  PubMed  Google Scholar 

  6. Gardner, A. W., Montgomery, P. S., & Parker, D. E. (2006). Metabolic syndrome impairs physical function, health-related quality of life, and peripheral circulation in patients with intermittent claudication. Journal of Vascular Surgery, 43, 1191–1196. doi:10.1016/j.jvs.2006.02.042.

    Article  PubMed  Google Scholar 

  7. Esposito, K., & Giugliano, D. (2005). Obesity, the metabolic syndrome, and sexual dysfunction. International Journal of Impotence Research, 17, 391–398. doi:10.1038/sj.ijir.3901333.

    Article  PubMed  CAS  Google Scholar 

  8. Daviglus, M. L., Liu, K., Pirzada, A., Yan, L. L., Garside, D. B., Feinglass, J., et al. (2003). Favorable cardiovascular risk profile in middle age and health-related quality of life in older age. Archives of Internal Medicine, 163, 2460–2468. doi:10.1001/archinte.163.20.2460.

    Article  PubMed  Google Scholar 

  9. Larsson, U., Karlsson, J., & Sullivan, M. (2002). Impact of overweight and obesity on health-related quality of life—a Swedish population study. International Journal of Obesity and Related Metabolic Disorders, 26, 417–424. doi:10.1038/sj.ijo.0801919.

    Article  PubMed  CAS  Google Scholar 

  10. Baiardi, F., Puglia, M. G., Valpiani, G., Sturani, A., Baraccani, C., Gentile, M., et al. (2005). Relationship between body weight, quality of life and cardiovascular risk factors: A general population based Italian experience. Eating and Weight Disorders, 10, 19–24.

    PubMed  CAS  Google Scholar 

  11. Jia, H., & Lubetkin, E. I. (2005). The impact of obesity on health-related quality-of-life in the general adult US population. Journal of Public Health, 27, 156–164. doi:10.1093/pubmed/fdi025.

    Article  PubMed  Google Scholar 

  12. Huang, I.-C., Frangakis, C., & Wu, A. W. (2006). The relationship of excess body weight and health-related quality of life: Evidence from a population study in Taiwan. International Journal of Obesity, 30, 1250–1259. doi:10.1038/sj.ijo.0803250.

    Article  PubMed  Google Scholar 

  13. Ford, E. S., Moriarty, D. G., Zack, M. M., Mokdad, A. H., & Chapman, D. P. (2001). Self-reported body mass index and health-related quality of life: Findings from the behavioural risk factor surveillance system. Obesity Research, 9, 21–31. doi:10.1038/oby.2001.4.

    Article  PubMed  CAS  Google Scholar 

  14. Mena-Martin, F. J., Martin-Escudero, J. C., Simal-Blanco, F., Carretero-Ares, J. L., Arzua-Mouronte, D., & Herreros-Fernandez, V. (2003). Health-related quality of life of subjects with known and unknown hypertension: Results from the population-based Hortega study. Journal of Hypertension, 21, 1283–1289. doi:10.1097/00004872-200307000-00015.

    Article  PubMed  CAS  Google Scholar 

  15. Bardage, C., & Isacson, D. G. (2001). Hypertension and health-related quality of life: An epidemiological study in Sweden. Journal of Clinical Epidemiology, 54, 172–181. doi:10.1016/S0895-4356(00)00293-6.

    Article  PubMed  CAS  Google Scholar 

  16. Lalonde, L., Clarke, A. E., Joseph, L., Mackenzie, T., & Grover, S. A. (2001). Canadian Collaborative Cardiac Assessment Group. Health-related quality of life with coronary heart disease prevention and treatment. Journal of Clinical Epidemiology, 54, 1011–1018. doi:10.1016/S0895-4356(01)00361-4.

    Article  PubMed  CAS  Google Scholar 

  17. Svartvik, L., Lidfeldt, J., Nerbrand, C., Samsioe, G., Schersten, B., & Nilsson, P. M. (2000). Dyslipidaemia and impaired well-being in middle-aged women reporting low sense of coherence. The Women’s Health in the Lund Area (WHLA). Scandinavian Journal of Primary Health Care, 18, 177–182. doi:10.1080/028134300453395.

    Article  PubMed  CAS  Google Scholar 

  18. Cox, D., Gonder-Frederick, L., McCall, A., Kovatchev, B., & Clarke, W. (2002). The effects of glucose fluctuation on cognitive function and QOL: The functional costs of hypoglycaemia and hyperglycaemia among adults with type 1 or type 2 diabetes. International Journal of Clinical Practice. Supplement, 129, 20–26.

    PubMed  Google Scholar 

  19. Schlotz, W., Ambery, P., Syddall, H. E., Crozier, S. R., Sayer, A. A., Cooper, C., et al. (2007). Specific associations of insulin resistance with impaired health-related quality of life in the Hertfordshire Cohort Study. Quality of Life Research, 16, 429–436. doi:10.1007/s11136-006-9129-5.

    Article  PubMed  Google Scholar 

  20. Sintonen, H. (2001). The 15D instrument of health-related quality of life: Properties and applications. Annals of Medicine, 33, 328–336. doi:10.3109/07853890109002086.

    Article  PubMed  CAS  Google Scholar 

  21. Sintonen, H. (1994). Outcome measurement in acid-related diseases. PharmacoEconomics, 5, 17–26.

    Article  Google Scholar 

  22. Aromaa, A., & Koskinen, S. (2004). Health and functional capacity in Finland. Baseline results of the Health 2000 health examination survey (p. 171). Publications of National Public Health Institute, Series B 12/2004.

  23. Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., et al. (2005). National Heart, Lung and Blood Institute. Diagnosis and management of the metabolic syndrome. Circulation, 112(17), 2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404.

    Article  PubMed  Google Scholar 

  24. Ford, E. S. (2005). Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care, 28, 2745–2749. doi:10.2337/diacare.28.11.2745.

    Article  PubMed  Google Scholar 

  25. Ilanne-Parikka, P., Eriksson, J. G., Lindstrom, J., Hamalainen, H., Keinanen-Kiukaanniemi, S., Laakso, M., et al. (2004). Prevalence of the metabolic syndrome and its components: Findings from a Finnish general population sample and the Diabetes Prevention Study cohort. Diabetes Care, 27, 2135–2140. doi:10.2337/diacare.27.9.2135.

    Article  PubMed  Google Scholar 

  26. Blazer, D. G., Hybels, C. F., & Fillenbaum, G. G. (2006). Metabolic syndrome predicts mobility decline in a community-based sample of older adults. Journal of the American Geriatrics Society, 54, 502–506. doi:10.1111/j.1532-5415.2005.00607.x.

    Article  PubMed  Google Scholar 

  27. Lakka, T. A., Laaksonen, D. E., Lakka, H. M., Mannikko, N., Niskanen, L. K., Rauramaa, R., et al. (2003). Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome. Medicine and Science in Sports and Exercise, 35, 1279–1286. doi:10.1249/01.MSS.0000079076.74931.9A.

    Article  PubMed  Google Scholar 

  28. Spencer, J. T., Jr. (2007). Metabolic-syndromic sensorineural hearing loss and increased noise vulnerability. Ear, Nose, and Throat Journal, 86, 314.

    PubMed  Google Scholar 

  29. Loevinger, B. L., Muller, D., Alonso, C., & Coe, C. L. (2007). Metabolic syndrome in women with chronic pain. Metabolism: Clinical and Experimental, 56, 87–93. doi:10.1016/j.metabol.2006.09.001.

    CAS  Google Scholar 

  30. Elenkov, I. J., Iezzoni, D. G., Daly, A., Harris, A. G., & Chrousos, G. P. (2005). Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation, 12, 255–269. doi:10.1159/000087104.

    Article  PubMed  CAS  Google Scholar 

  31. Vgontzas, A. N., Bixler, E. O., & Chrousos, G. P. (2006). Obesity-related sleepiness and fatigue: The role of the stress system and cytokines. Annals of the New York Academy of Sciences, 1083, 329–344. doi:10.1196/annals.1367.023.

    Article  PubMed  CAS  Google Scholar 

  32. Esposito, K., Ciotola, M., Marfella, R., Di Tommaso, D., Cobellis, L., & Giugliano, D. (2005). Sexual dysfunctions in women with the metabolic syndrome. Diabetes Care, 28, 756. doi:10.2337/diacare.28.3.756.

    Article  PubMed  Google Scholar 

  33. Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D’Andrea, F., et al. (2004). Effect of life style changes on erectile dysfunction in obese men: A randomized controlled trial. Journal of the American Medical Association, 291, 2978–2984. doi:10.1001/jama.291.24.2978.

    Article  PubMed  CAS  Google Scholar 

  34. Niskanen, L., Laaksonen, D. E., Punnonen, K., Mustajoki, P., Kaukua, J., & Rissanen, A. (2004). Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes, Obesity & Metabolism, 6, 208–215. doi:10.1111/j.1462-8902.2004.00335.x.

    Article  CAS  Google Scholar 

  35. Korhonen, S., Hippelainen, M., Vanhala, M., Heinonen, S., & Niskanen, L. (2003). The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: A controlled community-based study. Fertility and Sterility, 79, 1327–1334. doi:10.1016/S0015-0282(03)00347-9.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We are grateful to the Lapinlahti residents who took part in the study. We would also like to thank the staff members of the Lapinlahti Primary Health Care Centre and Kuopio University Hospital Medical Laboratory for their contribution to the study. This study would not have been possible without the financial support of the Lapinlahti Municipality and the Development Programme for the Prevention and Care of Diabetes in Finland (DEHKO/D2D) through the Northern Savo Hospital District.

Author information

Authors and Affiliations

  1. Family Practice Unit, Kuopio University Hospital & University of Kuopio, P.O. Box 1777, 70211, Kuopio, Finland

    Juhani Miettola

  2. Department of Medicine, Kuopio University Hospital & University of Kuopio, Kuopio, Finland

    Leo K. Niskanen

  3. Department of Psychiatry, Kuopio University Hospital & University of Kuopio, Kuopio, Finland

    Heimo Viinamäki

  4. Department of Public Health, University of Helsinki, Helsinki, Finland

    Harri Sintonen

  5. Family Practice Unit, Kuopio University Hospital & University of Kuopio, Kuopio, Finland

    Esko Kumpusalo

Authors
  1. Juhani Miettola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leo K. Niskanen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Heimo Viinamäki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harri Sintonen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Esko Kumpusalo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Juhani Miettola.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miettola, J., Niskanen, L.K., Viinamäki, H. et al. Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study. Qual Life Res 17, 1055–1062 (2008). https://doi.org/10.1007/s11136-008-9386-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-008-9386-6

Keywords

Search

Navigation