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Associations of Functional Status and Depressive Symptoms with Health-related Quality of Life in Cancer Patients

Quality of Life Research volume 15, pages 1565–1570 (2006)Cite this article

Abstract

Associations of functional status (as measured with the Karnofsky Index), depressive symptoms (as assessed with the Beck Depression Inventory), and sociodemographic characteristics with health-related quality of life (HrQoL; measured with the EORTC Quality of Life Questionnaire QLQ-C30) were assessed in 170 recently diagnosed cancer patients. A better functional status (p<0.001) and a lower level of depressive symptoms (p<0.001) were associated with better HrQoL. In addition, an interaction effect of functional status with HrQoL was found (p<0.001), indicating that stronger functional impairments were related to lower HrQoL in patients with low and average levels of depressive symptoms, but not in those with high levels of depressive symptoms. Associations of HrQoL with sociodemographic variables were not significant. It is concluded that functional decline does not additionally impair HrQoL when patients already have elevated levels of depressive symptoms.

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Author information

Affiliations

  1. Department of Developmental Psychology and Center for Applied Developmental Science, Friedrich Schiller University, Steiger 3/1, D-07743, Jena, Germany

    M. Pinquart

  2. Hospital of Psychiatry, Friedrich Schiller University, Jena, Germany

    A. Koch

  3. Department of Biological and Clinical Psychology, Friedrich Schiller University, Jena, Germany

    B. Eberhardt

  4. Department of Medical Psychology, Friedrich Schiller University, Jena, Germany

    C. Brix

  5. Hospital of Internal Medicine II, Friedrich Schiller University, Jena, Germany

    U. Wedding & B. Röhrig

Authors
  1. M. Pinquart
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  2. A. Koch
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  3. B. Eberhardt
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  4. C. Brix
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  5. U. Wedding
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  6. B. Röhrig
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Corresponding author

Correspondence to M. Pinquart.

Additional information

The trial was supported by the German Cancer Aid (Deutsche Krebshilfe), Grant 70-2445–Hö3.

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Pinquart, M., Koch, A., Eberhardt, B. et al. Associations of Functional Status and Depressive Symptoms with Health-related Quality of Life in Cancer Patients. Qual Life Res 15, 1565–1570 (2006). https://doi.org/10.1007/s11136-006-0016-x

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  • DOI: https://doi.org/10.1007/s11136-006-0016-x

Keywords

  • Cancer
  • Depression
  • Functional status
  • Health-related quality of life
  • Oncology