Skip to main content

Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

Quality of Life Research volume 15, pages 299–305 (2006)Cite this article

Abstract

Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. Methods: We studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and pain, urinary, and quality of life subscores were compared to a global response assessment (GRA). Effect sizes and Guyatt statistics were calculated to evaluate responsiveness; 95% confidence intervals were produced using bootstrapping. Results: All scores decreased over time with the largest decrease in subjects who reported on the GRA that they were markedly improved. The NIH-CPSI total, pain, and quality of life scores were highly responsive in the improved groups; the urinary score showed minimal responsiveness. There was no evidence of responsiveness among those subjects who worsened on the trial. ROC curves identified a 6-point decline in the NIH-CPSI total score as the optimal threshold to predict treatment response. Conclusions: The NIH-CPSI total score and pain and quality of life subscores are responsive to change over␣time.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. MS Litwin M McNaughton-Collins FJJ Fowler et al. (1999) ArticleTitleThe National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure J Urol 162 369–375 Occurrence Handle10.1016/S0022-5347(05)68562-X Occurrence Handle1:STN:280:DyaK1Mzjs1yhsA%3D%3D Occurrence Handle10411041

    Article  CAS  PubMed  Google Scholar 

  2. M McNaughton-Collins MP O’Leary EA Calhoun et al. (2001) ArticleTitleThe Spanish National Institutes of Health-Chronic Prostatitis Symptom Index: translation and linguistic validation J Urol 166 1800–1803

    Google Scholar 

  3. KJ Propert RB Alexander JC Nickel et al. (2002) ArticleTitleDesign of a multicenter randomized clinical trial for chronic prostatitis/chronic pelvic pain syndrome Urology 59 870–876 Occurrence Handle10.1016/S0090-4295(02)01601-1 Occurrence Handle12031372

    Article  PubMed  Google Scholar 

  4. RB Alexander KJ Propert AJ Schaeffer et al. (2004) ArticleTitleCiprofloxacin or tamsulosin in men with chronic prostatitis/chronic pelvic pain syndrome: a randomized, double-blind trial Ann Intern Med 141 581–589 Occurrence Handle1:CAS:528:DC%2BD2cXpslCqurg%3D Occurrence Handle15492337

    CAS  PubMed  Google Scholar 

  5. J Cohen (1988) Statistical Power Analysis for the Behavioral Sciences Lawrence Erlbaum Associates Hillsdale, NJ 381

    Google Scholar 

  6. G Guyatt S Walter G Norman (1987) ArticleTitleMeasuring change over time: assessing the usefulness of evaluative instruments J Chron Dis 40 171–178 Occurrence Handle1:STN:280:BiiC3sfhtFE%3D Occurrence Handle3818871

    CAS  PubMed  Google Scholar 

  7. B Efron RJ Tibshirani (1993) An Introduction to the Bootstrap Chapman and Hall San Francisco

    Google Scholar 

  8. RA Deyo P Diehr DL Patrick (1991) ArticleTitleReproducibility and responsiveness of health status measures. Statistics and strategies for evaluation Controlled Clinical Trials 12 142S–158S Occurrence Handle1:STN:280:By2C3snotFE%3D Occurrence Handle1663851

    CAS  PubMed  Google Scholar 

  9. M McNaughton-Collins MA Pontari MP O’Leary et al. (2001) ArticleTitleQuality of life is impaired in men with chronic prostatitis J Gen Intern Med 16 656–662 Occurrence Handle1:STN:280:DC%2BD3MnjsFegug%3D%3D Occurrence Handle11679032

    CAS  PubMed  Google Scholar 

  10. JA Turner MA Ciol M Korff ParticleVon R Berger (2003) ArticleTitleValidity and responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index J Urol 169 580–583 Occurrence Handle10.1016/S0022-5347(05)63957-2 Occurrence Handle12544311

    Article  PubMed  Google Scholar 

  11. GH Guyatt LB Berman M Townsend DW Taylor (1985) ArticleTitleShould study subjects see their previous responses? J Chron Dis 38 1003 Occurrence Handle1:STN:280:BimD2MbptFc%3D Occurrence Handle4066888

    CAS  PubMed  Google Scholar 

  12. MJ Barry WO Williford Y Chang et al. (1995) ArticleTitleBenign prostatic hyperplasia specific health status measures in clinical research: How much change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is perceptible to patients? J Urol 154 1770–1774 Occurrence Handle10.1016/S0022-5347(01)66780-6 Occurrence Handle1:STN:280:BymD3cfktFQ%3D Occurrence Handle7563343

    Article  CAS  PubMed  Google Scholar 

  13. RO Roberts DJ Jacobson CJ Girman T Rhodes MM Lieber SJ Jacobsen (2002) ArticleTitlePrevalence of prostatitis-like symptoms in a community based cohort of older men J Urol 168 2467 Occurrence Handle10.1016/S0022-5347(05)64170-5 Occurrence Handle12441942

    Article  PubMed  Google Scholar 

  14. JC Nickel J Downey D Hunter J Clark (2001) ArticleTitlePrevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index J Urol 165 842 Occurrence Handle1:STN:280:DC%2BD3M3jtlaqsA%3D%3D Occurrence Handle11176483

    CAS  PubMed  Google Scholar 

  15. DA Shoskes SI Zeitlin A Shahed J Rajfer (1999) ArticleTitleQuercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial Urology 54 960 Occurrence Handle10.1016/S0090-4295(99)00358-1 Occurrence Handle1:STN:280:DC%2BD3c%2FmvVWruw%3D%3D Occurrence Handle10604689

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    K. J. Propert & Y. Wang

  2. Departments of Urology and Health Services, David Geffen School of Medicine and School of Public Health, University of California, Los Angeles, CA, USA

    M. S. Litwin

  3. Division of Urology, University of Maryland School of Medicine, Baltimore, MD, USA

    R. B. Alexander

  4. Institute of Health Services Research and Health Policy Studies, and Department of Urology, Northwestern University Medical School, Chicago, IL, USA

    E. Calhoun

  5. Department of Urology, Queen’s University, Kingston, Canada

    J. C. Nickel

  6. Division of Urologic Surgery, Brigham and Women’s Hospital, Boston, MA, USA

    M. P. O’Leary

  7. Department of Urology, Temple University School of Medicine, USA

    M. Pontari

  8. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA

    M. McNaughton-Collins

  9. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall Room 614, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA

    K. J. Propert

Authors
  1. K. J. Propert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. S. Litwin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. B. Alexander
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Calhoun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. C. Nickel
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. P. O’Leary
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. M. Pontari
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. McNaughton-Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the Chronic Prostatitis Collaborative Research Network (CPCRN)

Corresponding author

Correspondence to K. J. Propert.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Propert, K.J., Litwin, M.S., Wang, Y. et al. Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). Qual Life Res 15, 299–305 (2006). https://doi.org/10.1007/s11136-005-1317-1

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-005-1317-1

Keywords

  • Chronic prostatitis
  • Chronic pelvic pain syndrome
  • Symptom index