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Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice

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Abstract

Black tea is one of the six major tea categories and has a variety of bioactivities. However, little is known about its comprehensive evaluation of hypoglycemic effects and potential mechanisms. In this study, we investigated the in vivo hypoglycemic activity and potential mechanism for aqueous extracts of ordinary black tea (BT) and selenium-enriched black tea (Se-BT) by using an established high-fat diet together with streptozotocin (STZ)-induced hyperglycemic mouse model. Additionally, we also explored their α-glucosidase inhibition activity. The results show that both BT and Se-BT had a favorable glycosidase inhibitory activity. Moreover, the intervention of BT and Se-BT could regulate the mRNA expression and the level of serum parameters related to glucose and lipid metabolisms. Accordingly, they could activate the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathway and alleviate insulin resistance (IR) and hyperglycemia. Moreover, supplementation of BT and Se-BT increased the richness and diversity of intestinal flora and altered the abundance of beneficial and harmful bacteria. Both BT and Se-BT could regulate glucose metabolism, alleviate tissue damage, and restore intestinal flora dysbiosis, suggesting that they could be used as a natural functional food for preventing hyperglycemia.

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Acknowledgements

The authors are thankful for the glucosamine selenium fertilizer supply by Shuanglin Liang from Jiangsu Shuanglin Marine Biological Pharmaceutical Co., Ltd, and tea production by Xueyun Wang from Enshi Selenium Impression Agricultural Development Co., Ltd. (Enshi, China).

Funding

The authors are grateful for financial sponsored by the Key project in Agricultural science and technology funded by Shanghai Science and Technology Commission (No. 20392002100), National Key R&D Program of China (No.2018YFC1604405), Fund of Shanghai Engineering Research Center of Plant Germplasm Resources (No. 17DZ2252700), and Research on the health function of tea and deep-processed products in preventing metabolic diseases (No. C-6105-20-074).

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  1. Lutong Shang and Fanglan Li contributed equally to this work

Authors and Affiliations

  1. Institute of Engineering Food, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai, 200234, China

    Lutong Shang, Fanglan Li, Jiangxiong Zhu, Chuanwen Sun & Yuanfeng Wang

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  1. Lutong Shang
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  2. Fanglan Li
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  3. Jiangxiong Zhu
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  4. Chuanwen Sun
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Contributions

LS and FL: writing-original draft and data preparation. JZ: Validation. CS: supervision and manuscript revision. YW: project administration and funding acquisition.

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Correspondence to Chuanwen Sun or Yuanfeng Wang.

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Shang, L., Li, F., Zhu, J. et al. Selenium-Enriched and Ordinary Black Teas Regulate the Metabolism of Glucose and Lipid and Intestinal Flora of Hyperglycemic Mice. Plant Foods Hum Nutr 78, 61–67 (2023). https://doi.org/10.1007/s11130-022-01022-w

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