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Common Bean Seeds Obtained by Plant Water Restriction Ameliorates Obesity-Associated Cardiovascular Risk and Insulin Resistance

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Abstract

The inclusion of beans in the diet has been recommended for obesity control. However, its beneficial effect varies depending on agroclimatic factors acting during plant development. The antiobesogenic capacity of Dalia bean (DB) seeds obtained by water restriction (WR) during the vegetative or reproductive stage of plant growth (50/100 and 100/50% of soil moisture in vegetative/reproductive stage, respectively), during the whole cycle (50/50), and well-watered plants (100/100) was researched. After phytochemical characterization, harvested beans from each experimental unit were pooled among treatments, based on a multivariate canonical discriminant analysis considering concentration of non-digestible carbohydrates (total, soluble and insoluble dietary fiber and resistant starch), phenolic compounds (total phenols, flavonoids, anthocyanins and condensed tannins) and total saponins, which showed no differences among replicas of each treatment. Obesity was induced in rats (UAZ-2015–36851) with a high fat diet (HFD) for four months. Afterwards, rats were fed with the HFD supplemented with 20% of cooked DB for three months. During treatment, 100/50 beans, improved blood triglycerides, cholesterol, and glucose, and alleviated early insulin resistance (IR) related to inhibition of lipase, α-amylase and –glucosidase activity. After sacrifice, a hypolipidemic capacity and atherogenic risk reduction was observed, especially from the 100/50 treatment, suggesting that intake of DB obtained from WR may prevent IR and dyslipidemia.

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Funding

INIFAP partially supported Mayra Denise Herrera [Grant No: 11192034464].

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Authors and Affiliations

  1. Campo Experimental Zacatecas (CEZAC-INIFAP), Carretera Zacatecas-Fresnillo Km 24.5, Calera de VR, Zacatecas, 98500, México

    Gabriela Salas-Lumbreras, Luis Roberto Reveles-Torres, Miguel Servín-Palestina & Mayra Denise Herrera

  2. Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Preparatoria No. 301, Colonia Hidráulica, Zacatecas, Zacatecas, 98068, México

    Gabriela Salas-Lumbreras, Luis Roberto Reveles-Torres & Jesús Adrián López

  3. Campo Experimental Bajío (CEBAJ-INIFAP), Carretera Celaya-San Miguel de Allende Km. 6.5, Celaya, Guanajuato, 38010, México

    Jorge Alberto Acosta-Gallegos

  4. Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Siglo XXI, Villanueva - Zacatecas, La Escondida, Zacatecas, Zacatecas, 98160, México

    Claudia Araceli Reyes-Estrada

Authors
  1. Gabriela Salas-Lumbreras
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  2. Luis Roberto Reveles-Torres
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  3. Miguel Servín-Palestina
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  4. Jorge Alberto Acosta-Gallegos
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  5. Mayra Denise Herrera
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  6. Claudia Araceli Reyes-Estrada
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  7. Jesús Adrián López
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Contributions

MDH: Conceptualization, Writing—original draft, Methodology, Investigation, Formal analysis, Project administration, Funding acquisition. GSL: Methodology, Investigation. LRRT: Visualization, Resources. MSP: Bean cultivation, Project administration. JAAG: Resources. CARE: Methodology, Resources. JAL: Writing—review & editing, Supervision, Data analysis.

Corresponding authors

Correspondence to Mayra Denise Herrera, Claudia Araceli Reyes-Estrada or Jesús Adrián López.

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Registration number for animal use: UAZ-2015–36851 (August 2015- August 2017). Coordinación de Investigación y Posgrado, Universidad Autónoma de Zacatecas (UAZ).

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Salas-Lumbreras, G., Reveles-Torres, L.R., Servín-Palestina, M. et al. Common Bean Seeds Obtained by Plant Water Restriction Ameliorates Obesity-Associated Cardiovascular Risk and Insulin Resistance. Plant Foods Hum Nutr 78, 38–45 (2023). https://doi.org/10.1007/s11130-022-01019-5

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