Abstract
The common reason for mortality globally is myocardial infarction. The study aimed to evaluate Passiflora edulis (PE) fruit juice potential in the experimental isoproterenol (ISO) treated rat model to manage myocardial injury. ISO (20 mg/100 g body weight) treated rats showed a significant increment in serum marker enzymes lactate dehydrogenase (LDH) and creatinine kinase (CK), serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP) and serum acid phosphatase (ACP) activity. Besides, phosphorus and calcium, serum cholesterol, and triglyceride levels (TG) were high in ISO groups. A significant decline in antioxidant activity and histopathological alteration was observed in ISO treated groups. PE juice pre-treatment (2 ml/kg) for 28 days and ISO treatment on the 29th and 30th days showed a protective effect on distorted biochemical and histopathologic parameters compared with reference drug metoprolol. These findings indicate the cardioprotective effect of PE juice on ISO-induced myocardial infracted rats.
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Pejin B, Kien-Thai Y, Stanimirovic B, Vuckovic G, Belic D, Sabovljevic M (2012) Heavy metal content of a medicinal moss tea for hypertension. Nat Prod Res 26:2239–2242
Pejin B, Kien-Thai Y, Bogdanovic-Pristov J, Pejin I, Spasojević I (2012) In vitro investigation of the antihypertensive effect of the moss Rhodobryum ontariense (kindb.). Dig J Nanomater Bios 7(1):353–359
Zheng J, Zhou Y, Li S, Zhang P, Zhou T, Xu DP, Li HB (2017) Effects and mechanisms of fruit and vegetable juices on cardiovascular diseases. Int J Mol Sci 18(3):555
Bhardwaj RL, Nandal U, Pal A, Jain S (2014) Bioactive compounds and medicinal properties of fruit juices. Fruits 69:391–412
Thokchom R, Mandal G (2017) Production preference and importance of passion fruit (Passiflora edulis): a review. J Agric Eng Food Technol 4:27–30
Nerdy N, Ritarwan K (2019) Hepatoprotective activity and nephroprotective activity of peel extract from three varieties of the passion fruit (Passiflora Sp.) in the albino rat. Open Access Maced J Med Sci 7:536–542
Septembre-Malaterre A, Stanislas G, Douraguia E, Gonthier MP (2016) Evaluation of nutritional and antioxidant properties of the tropical fruits banana, litchi, mango, papaya, passion fruit and pineapple cultivated in Réunion French Island. Food Chem 212:225–233
Xu FQ, Wang C, Yang L, Luo H, Fan W, Zi C et al (2013) C-dideoxyhexosyl flavones from the stems and leaves of Passiflora edulis Sims. Food Chem 136:94–99
Cortés RNF, Guzmán IV, Martínez-Bustos F (2014) Effects of some extrusion variables on physicochemical characteristics of extruded corn starch-passion fruit pulp (Passiflora edulis) snacks. Plant Foods Hum Nutr 69:365–371
Fan Y (2019) Cardioprotective effect of rhapontigenin in isoproterenol-induced myocardial infarction in a rat model. Pharmacology 103:291–302
Mohan M, Patankar P, Ghadi P, Kasture S (2010) Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother 1(1):32–37
Larayetan R, Ololade ZS, Ogunmola OO, Ladokun A (2019) Phytochemical constituents, antioxidant, cytotoxicity, antimicrobial, antitrypanosomal, and antimalarial potentials of the crude extracts of Callistemon citrinus. Evid Based Complement Alternat Med 28(2019):5410923
Saeed N, Khan MR, Shabbir M (2012) Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med 12:221
Behera S, Babu SM, Ramani RY, Choudhury P, Rajeshree P (2012) Cardioprotective effect of Pongamia pinnata hydro-alcoholic leaf extract against isoproterenol induced myocardial infarction in wistar albino rats. Int J Med Pharm Sci 2:1–5
Srivastav RK, Siddiqui HH, Mahmood T, Ahsan F (2013) Evaluation of cardioprotective effect of silk cocoon (Abresham) on isoprenaline-induced myocardial infarction in rats. Avicenna J Phytomed 3:216–223
Chikku AM, Rajamohan T (2012) Coconut haustorium maintains cardiac integrity and alleviates oxidative stress in rats subjected to isoproterenol-induced myocardial infarction. Indian J Pharm Sci 74:397–402
Slavin JL, Lloyd B (2012) Health benefits of fruits and vegetables. Adv Nutr 3(4):506–516
Selani M, Bianchini A, Ratnayake WS, Flores RA, Massarioli AP, Matias de Alencar S, Brazaca SGC (2016) Physicochemical, functional and antioxidant properties of tropical fruits co-products. Plant Foods Hum Nutr 71:137–144
Fernandes L, Pereira JA, Lopéz-Cortés I, Salazar DM, Ramalhosa EC (2015) Physicochemical changes and antioxidant activity of juice, skin, pellicle and seed of pomegranate (cv. Mollar de Elche) at different stages of ripening. Food Technol Biotechnol 53(4):397–406
Manjunatha S, Althaf HS, Maruthi PE, Suliman YAlO, Altaf M, Lakshmi DK (2020) Combined cardio-protective ability of syringic acid and resveratrol against isoproterenol induced cardio-toxicity in rats via attenuating NF-kB and TNF-α pathways. Sci Rep 10:3426
Cozzolino M, Ciceri P, Galassi A, Mangano M, Carugo S, Capelli I, Cianciolo G (2019) The key role of phosphate on vascular calcification. Toxins 11(4):213
Karwowski W, Naumnik B, Szczepański M, Myśliwiec M (2012) The mechanism of vascular calcification - a systematic review. Med Sci Monit 18(1):RA1–RA11
Ellam TJ, Chico TJ (2011) Phosphate: The new cholesterol? The role of the phosphate axis in non-uremic vascular disease. Atherosclerosis 220:310–318
Zeraik ML, Yariwake JH (2010) Quantification of isoorientin and total flavonoids in Passiflora edulis fruit pulp by HPLC-UV/DAD. Microchem J 96:86–89
Patel SS, Goyal RK (2011) Cardioprotective effects of gallic acid in diabetes-induced myocardial dysfunction in rats. Pharmacognosy Res 3(4):239–245
Zafar F, Jahan N, Khalil-Ur-Rahman Khan A, Akram W (2015) Cardioprotective potential of polyphenolic rich green combination in catecholamine induced myocardial necrosis in rabbits. Evid Based Complement Altern Med 2015:1–9
Mnafgui K, Derbali A, Sayadi S, Gharsallah N, Elfeki A, Allouche N (2015) Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats. J Food Sci Technol 52(7):4369–4437
Acknowledgements
The first author acknowledges UGC Dr. D.S.Kothari Post Doctoral Fellowship (No.F.4 − 2/2006 (BSR)/BL/14–15/0480), and the corresponding author acknowledges UGC-BSR Faculty fellowship (F No.4–5(11)/2019(BSR), University Grants Commission (UGC), New Delhi for research grant as financial support and the University of Kerala for conducting this work. The authors also acknowledge Dr. Nisha, Senior Scientist, CSIR NIIST, Trivandrum for HPLC analysis.
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Soumya, R.S., Raj, K.B. & Abraham, A. Passiflora edulis (var. Flavicarpa) Juice Supplementation Mitigates Isoproterenol‐induced Myocardial Infarction in Rats. Plant Foods Hum Nutr 76, 189–195 (2021). https://doi.org/10.1007/s11130-021-00891-x
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DOI: https://doi.org/10.1007/s11130-021-00891-x