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Passiflora edulis (var. Flavicarpa) Juice Supplementation Mitigates Isoproterenol‐induced Myocardial Infarction in Rats

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Abstract

The common reason for mortality globally is myocardial infarction. The study aimed to evaluate Passiflora edulis (PE) fruit juice potential in the experimental isoproterenol (ISO) treated rat model to manage myocardial injury. ISO (20 mg/100 g body weight) treated rats showed a significant increment in serum marker enzymes lactate dehydrogenase (LDH) and creatinine kinase (CK), serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP) and serum acid phosphatase (ACP) activity. Besides, phosphorus and calcium, serum cholesterol, and triglyceride levels (TG) were high in ISO groups. A significant decline in antioxidant activity and histopathological alteration was observed in ISO treated groups. PE juice pre-treatment (2 ml/kg) for 28 days and ISO treatment on the 29th and 30th days showed a protective effect on distorted biochemical and histopathologic parameters compared with reference drug metoprolol. These findings indicate the cardioprotective effect of PE juice on ISO-induced myocardial infracted rats.

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Acknowledgements

The first author acknowledges UGC Dr. D.S.Kothari Post Doctoral Fellowship (No.F.4 − 2/2006 (BSR)/BL/14–15/0480), and the corresponding author acknowledges UGC-BSR Faculty fellowship (F No.4–5(11)/2019(BSR), University Grants Commission (UGC), New Delhi for research grant as financial support and the University of Kerala for conducting this work. The authors also acknowledge Dr. Nisha, Senior Scientist, CSIR NIIST, Trivandrum for HPLC analysis.

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Correspondence to Annie Abraham.

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Soumya, R.S., Raj, K.B. & Abraham, A. Passiflora edulis (var. Flavicarpa) Juice Supplementation Mitigates Isoproterenol‐induced Myocardial Infarction in Rats. Plant Foods Hum Nutr 76, 189–195 (2021). https://doi.org/10.1007/s11130-021-00891-x

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