Skip to main content

Advertisement

SpringerLink
Log in

Avocado Creole Peel Ameliorates Metabolic Alterations Caused by a High Sucrose Fat Diet in a Wistar Rats Model

  • Original Paper
  • Published:
Plant Foods for Human Nutrition Aims and scope Submit manuscript

Abstract

High-sucrose high-fat diets are one of the causes of malnutrition, and may induce metabolic alterations such as dyslipidemia, insulin resistance, and adipogenesis. The objective of this work was to investigate the possible protective effect of traditionally edible avocado creole peel (Persea americana Mill var. drymifolia) when consuming a high-sucrose and fat diet (HSFD). The experimental animal model included 21 male Wistar rats divided in three groups: the control group received a standard diet of purina®, the HSFD group received a high fat diet plus 30% sucrose in drinking water, and finally the HSFD + AP group received the HSFD diet supplemented with 200 mg/kg of avocado peel for 14 weeks. It was observed that alterations included higher cholesterol, glucose, insulin, fatty acids and TNF-α levels as well as lower HDL, and adiponectin. The addition of avocado peel reverted some of these effects, resulting in normal values of triglicerides, insulin and adiponectin, while attenuated the levels of total cholesterol. Liver weight of the group added with avocado peel was similar to the control group. The neuronal density in the hippocampal areas CA1 and dentate gyrus DC were lower in the high glucose fat group, while the ingestion of the avocado peel showed a neuroprotective effect. The avocado creole ingestion reverted or attenuated most of the metabolic effects caused by a high-sucrose fat diet which was attributed to the compounds detected by HPLC-MS and GC-MS that included bioactive polyphenols such as flavanol quercetin, flavanone naringenin, flavan 3-ol catechin, cyanidin 3-glucoside, pelargonidin 3-glucoside, pelargonidin 3-rhamnoside, hydroxydelphinidin, eugenol and estragole.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Billingsley H, Carbone S, Lavie C (2018) Dietary fats and chronic noncommunicable diseases. Nutrients 10:1385–1401

  2. Calvo-Ochoa E, Arias G (2014) Celular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and alzheimer´s disease: studies in animal models. Diabetes Metab Res Rev 31:1–13

  3. Bhuyan DJ, Alsherbiny MA, Perera S, Low M, Basu A, Devi OA, Barrooah MS, Li CG, Papoutsis K (2019) The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits. Antiox 8:426

  4. Espinosa-Velázquez R, Dorantes-Alvarez L, Gutiérrez-López GF, García-Armenta E, Sánchez-Segura L, Perea-Flores MJ, Ceballos-Reyes GM, Ortíz-Moreno A (2016) Morpho-structural description of unripe and ripe avocado pericarp (Persea americana Mill var. drymifolia) description. Rev Mex Ing Quim 15(2):469–480. https://rmiq.org/ojs311/index.php/rmiq/article/view/1144

  5. Corrales-García JE, García-Mateos MR, Martínez-Lopéz E, Barrientos-Priego AF, Ybarra-Moncada MC, Ibarra-Estrada E, Méndez-Zúñiga SM, Becerra-Morales D (2019) Anthocyanin and oil contents, fatty acids profiles and antioxidant activity of Mexican landrace avocado fruits. Plant Foods Hum Nutr 74:210–215. https://doi.org/10.1007/s11130-019-00721-1

  6. Yoo KM, Lee CH, Lee H, Moon B, Lee CY (2008) Relative antioxidant and cytoprotective activities of common herbs. Food Chem 106:929–936

  7. National Research Council (US) (2011) Guide for the care and use of laboratory animals. National Academies Press, Washington, DC, pp 11–40

  8. Guzmán-Gerónimo RI, Alarcón-Zavaleta TM, Oliart-Ros RM, Meza-Alvarado JE, Herrera-Meza S, Chávez-Servia JL (2016) Blue maize extract improves blood pressure, lipid profiles, and adipose tissue in high-sucrose diet-induced metabolic syndrome in rats. J Med Food 20:110–115

    Article  Google Scholar 

  9. Kusindarta DL, Wihadmadyatami H, Haryanto A (2018) The analysis of hippocampus neuronal density (CA1 and CA3) after Ocimum sanctum ethanolic extract treatment on the young adulthood and middle age rat model. Vet World 11(2):135–140

    Article  CAS  Google Scholar 

  10. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Elsevier Ltd., London

    Google Scholar 

  11. Cory H, Passarello S, Szeto J, Tamez M, Mattei J (2018) The role of polyphenols in human health and food systems: a mini-review. Front Nutr 5:87. https://doi.org/10.3389/fnut.2018.00087

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Drewnowski A, Almiron-Roig E (2010) Human perceptions and preferences for fat-rich foods. In: Montmayeur JP, le Coutre J (eds) Fat detection: taste, texture, and post ingestive effects, 1st edn. CRC Press/Taylor & Francis, Boca Raton, FL, pp 243–268

  13. Cao L, Liu X, Cao H, Lv Q, Tong N (2012) Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance. Oxid Med Cel Longev 2012:374346

  14. Chaiittianan R, Sutthannut K, Rattanathongkom A (2017) Purple corn silk: a potential anti-obesity agent with inhibition on adipogenesis and induction on lipolysis and apoptosis in adipocytes. J Ethnopharmacol 201:9–16

    Article  CAS  Google Scholar 

  15. Pu P, Gao D, Mohamed S, Chen J, Zhang J, Zhou X, Zhou N, Xie J, Jiang H (2012) Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high- fat diet. Arch Biochem Biophys 518:61–70

  16. Luna-Vital D, Luzardo-Ocampo I, Cuellar-Nuñez L, Loarca-Pina G, Gonzalez de Mejia E (2019) Maize extract rich in ferulic acid and anthocyanins prevents high-fat induced obesity in mice by modulationg SIRT1, AMPK, and IL-6 associated metabolic and inflammatory pathways. J Nutr Biochem 79:108343. https://doi.org/10.1016/j.jnutbio.2020.108343

  17. Tsuda T, Ueno Y, Kojo H, Yoshikawa T, Osawa T (2005) Gene expression profile of isolated rat adipocytes treated with anthocyanins. Biochim Biophys Acta 1733:137–147

    Article  CAS  Google Scholar 

  18. Huang K, Liang X, Zhong Y, He W, Wang Z (2014) 5-Caffeoylquinic acid decreases diet-induced obesity in rats bymodulating PPARα and LXRα transcription. J Sci Food Agric 95:1903–1910

  19. Bloemer J, Pinky P, Govindarajulu M, Hong H, Judd R, Amin R, Moore T, Dhanasekaran M, Reed M, Suppiramaniam V (2018) Role of adiponectin in central nervous system disorders. Neural Plast 2018:4593530. https://doi.org/10.1155/2018/4593530

  20. Wu T, Tang Q, Gao Z, Yu Z, Song H, Zheng X, Chen W (2013) Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS One 8:10

    PubMed Central  Google Scholar 

  21. Bracke A, Domanska G, Bracke K, Harzsch S, Brandt JV, Bröker B, Halbach O (2019) Obesity impairs and adult hippocampal neurogenesis. J Exp Neurosci 13:1–10

    Article  Google Scholar 

  22. Valladolid-Acebes I, Merino B, Principato A, Fole A, Barbas C, Lorenzo MP, Gracía A, Del Olmo N, Ruiz-Gayo M, Cano V (2012) High- fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. Am J Physiol Endocrinol Metab 302:396–402

    Article  Google Scholar 

  23. Basil A, Soulet S, Chaher N, Mérillon JM, Chibane M, Monti JP, Richard T (2012) Wine polyphenols: potential agents in neuroprotection. Oxid Med Cell Longev 2012:805762. https://doi.org/10.1155/2012/805762

  24. Gómez-Serranillos MP, Martín S, Ortega T, Palomina OM, Palomina OM, Prodanov M, Vacas V, Hernández T, Estrella I, Carretero ME (2009) Study of red wine neuroprotection on astrocytes. Plant Foods Hum Nutr 64:238–243

  25. Tsuda T (2012) Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Mol Nutr Food Res 56:159–170

  26. Pereira GD, Cavegn N, Nix A, Do Nascimento MC, Stangl D, Anwar MS, Nardi AE, Franca PG, Thuret S (2012) The role of dietary polyphenols on adult hippocampal neurogenesis: molecular mechanisms and behavioural effects on depression and anxiety. Oxid Med Cell Longev 2012:541971. https://doi.org/10.1155/2012/541971

Download references

Acknowledgements

This work was supported by the Instituto Politécnico Nacional (Mexico) projects SIP 20201014 and 20195428.

Author information

Authors and Affiliations

  1. Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Departamento de Ingeniería Bioquímica, Unidad Profesional Adolfo López Mateos, Av. Wilfrido Massieu S/N esq. Manuel L. Stampa, Nueva Industrial Vallejo, Gustavo A. Madero, C.P. 07738, Ciudad de México, México

    Delia Miñón-Hernández, Lidia Dorantes-Alvarez & Gustavo F. Gutiérrez-López

  2. Institutos de Ciencias Básicas, Neuroetologia, Investigaciones Psicológicas, Facultad de Bioanálisis, Universidad Veracruzana, Xalapa, Ver, México

    Rosa Isela Guzmán-Gerónimo, Mayvi Alvarado-Olivarez, Socorro Herrera-Meza & Isela Santiago-Roque

  3. Instituto Politécnico Nacional, Centro de Nanociencias y Micro y Nanotecnologías, Ciudad de México, México

    Mayra Beatriz Gómez-Patiño & Daniel Arrieta-Baez

Authors
  1. Delia Miñón-Hernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lidia Dorantes-Alvarez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rosa Isela Guzmán-Gerónimo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mayvi Alvarado-Olivarez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Socorro Herrera-Meza
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Isela Santiago-Roque
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gustavo F. Gutiérrez-López
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mayra Beatriz Gómez-Patiño
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Daniel Arrieta-Baez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lidia Dorantes-Alvarez.

Ethics declarations

Conflict of Interest

The authors declare that there is no conflict of interest in the study.

Electronic Supplementary Material

ESM 1

(DOCX 23 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miñón-Hernández, D., Dorantes-Alvarez, L., Guzmán-Gerónimo, R.I. et al. Avocado Creole Peel Ameliorates Metabolic Alterations Caused by a High Sucrose Fat Diet in a Wistar Rats Model. Plant Foods Hum Nutr 76, 12–19 (2021). https://doi.org/10.1007/s11130-020-00867-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11130-020-00867-3

Keywords

Search

Navigation