Plant Foods for Human Nutrition

, Volume 74, Issue 2, pp 200–203 | Cite as

Watermelon Juice: a Novel Functional Food to Increase Circulating Lycopene in Older Adult Women

  • Amy C. EllisEmail author
  • Tanja Dudenbostel
  • Kristi Crowe-White
Original Paper


Because of accruing oxidative stress with advancing age, older adults may benefit from increased dietary intake of lycopene, a lipophilic carotenoid with potent antioxidant properties. Yet, intake of dietary lycopene as well as circulating lycopene levels are known to decrease with aging. Watermelon is one of the few food sources of dietary lycopene. Because heat treatment increases lycopene bioavailability, ingestion of watermelon in pasteurized juice form may be an optimal delivery vehicle to increase lycopene levels in older adults. However, due to its lipophilic nature, there are concerns that co-ingestion of dietary fat may be necessary for efficient intestinal absorption of lycopene. Thus, this feasibility study aimed to examine the effects of a one-time dose of 100% pasteurized watermelon juice on circulating lycopene concentrations of postmenopausal women after a 10-h overnight fast. Blood was sampled from eight women before and 2 h after ingestion of 360 ml of juice, and serum lycopene was measured by ultra-high performance liquid chromatography. Circulating lycopene levels increased by three-fold (p < 0.001) with increases observed for every participant. Results demonstrate that 100% watermelon juice is a palatable, effective means of increasing serum lycopene in older adult women, a group at risk for low carotenoid intake. Trial registration: identifier: NCT03608254.


Lycopene Watermelon Older adults 



Body mass index


Cardiovascular disease


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    Technomic Company (2017) Flavor Consumer Trend Report. Accessed 24 July 2018
  2. 2.
    Figueroa A, Wong A, Jaime SJ, Gonzales JU (2017) Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Curr Opin Clin Nutr Metab Care 20(1):92–98. Google Scholar
  3. 3.
    Figueroa A, Sanchez-Gonzalez MA, Perkins-Veazie PM, Arjmandi BH (2011) Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study. Am J Hypertens 24(1):40–44. Google Scholar
  4. 4.
    Figueroa A, Sanchez-Gonzalez MA, Wong A, Arjmandi BH (2012) Watermelon extract supplementation reduces ankle blood pressure and carotid augmentation index in obese adults with prehypertension or hypertension. Am J Hypertens 25(6):640–643. Google Scholar
  5. 5.
    Figueroa A, Wong A, Hooshmand S, Sanchez-Gonzalez MA (2013) Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women. Menopause 20(5):573–577. Google Scholar
  6. 6.
    Figueroa A, Wong A, Kalfon R (2014) Effects of watermelon supplementation on aortic hemodynamic responses to the cold pressor test in obese hypertensive adults. Am J Hypertens 27(7):899–906. Google Scholar
  7. 7.
    Massa NM, Silva AS, Toscano LT, Silva JD, Persuhn DC, Goncalves Mda C (2016) Watermelon extract reduces blood pressure but does not change sympathovagal balance in prehypertensive and hypertensive subjects. Blood Press 25(4):244–248. Google Scholar
  8. 8.
    Figueroa A, Sanchez-Gonzalez M, Wong A, Arjmandi B (2012) Arterial stiffness and blood pressure are reduced after watermelon supplementation in obese with prehypertension and hypertension. FASEB J 26:385Google Scholar
  9. 9.
    Arab L, Steck S (2000) Lycopene and cardiovascular disease. Am J Clin Nutr 71(6 Suppl):1691S–1695S discussion 1696S–1697SGoogle Scholar
  10. 10.
    Joo YE, Karrasch T, Muhlbauer M, Allard B, Narula A, Herfarth HH, Jobin C (2009) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One 4(2):e4562. Google Scholar
  11. 11.
    Hung CF, Huang TF, Chen BH, Shieh JM, Wu PH, Wu WB (2008) Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur J Pharmacol 586(1–3):275–282. Google Scholar
  12. 12.
    Li X, Xu J (2013) Lycopene supplement and blood pressure: an updated meta-analysis of intervention trials. Nutrients 5(9):3696–3712. Google Scholar
  13. 13.
    Kim OY, Yoe HY, Kim HJ, Park JY, Kim JY, Lee SH, Lee JH, Lee KP, Jang Y, Lee JH (2010) Independent inverse relationship between serum lycopene concentration and arterial stiffness. Atherosclerosis 208(2):581–586. Google Scholar
  14. 14.
    Woodside JV, McGrath AJ, Lyner N, McKinley MC (2015) Carotenoids and health in older people. Maturitas 80(1):63–68. Google Scholar
  15. 15.
    Petyaev IM (2016) Lycopene deficiency in ageing and cardiovascular disease. Oxidative Med Cell Longev 2016: 6 3218605.
  16. 16.
    Jung SE, Ellis A, Crowe-White K (2018) Intention of older women to consume 100% watermelon juice for vascular health: an application of the theory of planned behavior. J Nutr Gerontol Geriatr 37(2):130–143. Google Scholar
  17. 17.
    Moran NE, Erdman JW Jr, Clinton SK (2013) Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution. Arch Biochem Biophys 539(2):171–180. Google Scholar
  18. 18.
    Brown MJ, Ferruzzi MG, Nguyen ML, Cooper DA, Eldridge AL, Schwartz SJ, White WS (2004) Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am J Clin Nutr 80(2):396–403. Google Scholar
  19. 19.
    White WS, Zhou Y, Crane A, Dixon P, Quadt F, Flendrig LM (2017) Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables. Am J Clin Nutr 106(4):1041–1051. Google Scholar
  20. 20.
    Story EN, Kopec RE, Schwartz SJ, Harris GK (2010) An update on the health effects of tomato lycopene. Annu Rev Food Sci Technol 1:189–210. Google Scholar
  21. 21.
    Edwards AJ, Vinyard BT, Wiley ER, Brown ED, Collins JK, Perkins-Veazie P, Baker RA, Clevidence BA (2003) Consumption of watermelon juice increases plasma concentrations of lycopene and beta-carotene in humans. J Nutr 133(4):1043–1050Google Scholar
  22. 22.
    Crowe KM (2014) Optimizing protein precipitation efficiency for assessing the contribution of low molecular weight compounds to serum antioxidant capacity. Clin Biochem 47(15):116–118. Google Scholar
  23. 23.
    Maurer MM, Mein JR, Chaudhuri SK, Constant HL (2014) An improved UHPLC-UV method for separation and quantification of carotenoids in vegetable crops. Food Chem 165:475–482. Google Scholar
  24. 24.
    Shi J, Le Maguer M (2000) Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Biotechnol 20(4):293–334. Google Scholar
  25. 25.
    Cohn W, Thurmann P, Tenter U, Aebischer C, Schierle J, Schalch W (2004) Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets. Eur J Nutr 43(5):304–312. Google Scholar
  26. 26.
    Kris-Etherton P, Eckel RH, Howard BV, St Jeor S, Bazzarre TL, Nutrition Committee Population Science C, Clinical Science Committee of the American Heart Association (2001) AHA science advisory: Lyon diet heart study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association step I dietary pattern on cardiovascular disease. Circulation 103(13):1823–1825Google Scholar
  27. 27.
    Basu A, Imrhan V (2007) Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur J Clin Nutr 61(3):295–303. Google Scholar
  28. 28.
    Moore LV, Thompson FE (2015) Adults meeting fruit and vegetable intake recommendations - United States, 2013. MMWR Morb Mortal Wkly Rep 64(26):709–713Google Scholar
  29. 29.
    Ervin R (2008) Healthy eating index scores among adults, 60 years of age and over. Centers for Disease Control and Prevention (CDC). Accessed 18 Nov 2014
  30. 30.
    Emami E, de Souza RF, Kabawat M, Feine JS (2013) The impact of edentulism on oral and general health. Int J Dent 2013:1-7 498305.,
  31. 31.
    Locher JL, Ritchie CS, Roth DL, Sen B, Vickers KS, Vailas LI (2009) Food choice among homebound older adults: motivations and perceived barriers. J Nutr Health Aging 13(8):659–664Google Scholar
  32. 32.
    Esfahani A, Wong JM, Truan J, Villa CR, Mirrahimi A, Srichaikul K, Kendall CW (2011) Health effects of mixed fruit and vegetable concentrates: a systematic review of the clinical interventions. J Am Coll Nutr 30(5):285–294Google Scholar
  33. 33.
    Crowe-White K, Parrott JS, Stote KS, Gutschall M, Benson-Davies S, Droke E, O'Neil CE, Wolfram T, Ziegler P (2017) Metabolic impact of 100% fruit juice consumption on antioxidant/oxidant status and lipid profiles of adults: an evidence-based review. Crit Rev Food Sci Nutr 57(1):152–162. Google Scholar
  34. 34.
    Ellis AC, Dudenbostel T, Locher JL, Crowe-White K (2016) Modulating oxidative stress and inflammation in elders: the MOXIE study. J Nutr Gerontol Geriatr 35(4):219–242. Google Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Human NutritionUniversity of AlabamaTuscaloosaUSA
  2. 2.Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Department of Human NutritionUniversity of AlabamaTuscaloosaUSA

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