Influence of Dietary Avocado on Gut Health in Rats

Abstract

This study investigated the impact of diets containing various levels of avocado (5, 10 and 15%) on gut health in rats fed for six weeks. Avocado-fed rats had significantly higher food intakes while their body weights remained similar to the control diet-fed rats. No significant changes in intestinal bacterial populations (ileum, cecum and colon) were found in rats fed avocado diets compared to the control diet. Ileum and colon tissues of rats fed avocado diets showed significantly higher expression of genes (β-defensin 1, mucin 3 or mucin 4) and a greater number of mucin-producing goblet cells in the colon. The percentage of avocado in the diet had varying effects in altering the biomarkers, whereby diet containing 15% avocado was the more effective diet. This study delivers new knowledge on the role of avocado on gut health in rats.

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References

  1. 1.

    Dreher ML, Davenport AJ (2013) Hass avocado composition and potential health effects. Crit Rev Food Sci Nutr 53:738–750

    CAS  Article  Google Scholar 

  2. 2.

    Simpson HL, Campbell BJ (2015) Review article: dietary fibre–microbiota interactions. Aliment Pharmacol Ther 42:158–179

    CAS  Article  Google Scholar 

  3. 3.

    Conlon M, Bird A (2015) The impact of diet and lifestyle on gut microbiota and human health. Nutrients 7:17

    Article  Google Scholar 

  4. 4.

    Sivakumaran S, Huffman L, Sivakumaran S (2017) The concise New Zealand food composition tables, 12th edn. The New Zealand Institute for Plant and Food Research Limited and Ministry of Health, Palmerston North

    Google Scholar 

  5. 5.

    Fava F, Gitau R, Griffin BA, Gibson GR, Tuohy KM, Lovegrove JA (2013) The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome ‘at-risk’ population. Int J Obes 37:216–223

    CAS  Article  Google Scholar 

  6. 6.

    Louis P, Hold GL, Flint HJ (2014) The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol 12:661–672

    CAS  Article  Google Scholar 

  7. 7.

    Bentley-Hewitt K, Blatchford P, Parkar S, Ansell J, Pernthaner A (2012) Digested and fermented green kiwifruit increases human β-defensin 1 and 2 production in vitro. Plant Foods Hum Nutr 67:208–214

    CAS  Article  Google Scholar 

  8. 8.

    Hazlett L, Wu M (2011) Defensins in innate immunity. Cell Tissue Res 343:175–188

    CAS  Article  Google Scholar 

  9. 9.

    Tanabe H, Ito H, Sugiyama K, Kiriyama S, Morita T (2006) Dietary indigestible components exert different regional effects on luminal mucin secretion through their bulk-forming property and fermentability. Biosci Biotechnol Biochem 70:1188–1194

    CAS  Article  Google Scholar 

  10. 10.

    Paturi G, Butts CA, Bentley-Hewitt KL, Ansell J (2014) Influence of green and gold kiwifruit on indices of large bowel function in healthy rats. J Food Sci 79:H1611–H1620

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We thank Sheridan Martell, Hannah Dinnan, Sue Middlemiss-Kraak, Halina Stoklosinski and Thanuja Herath for their technical assistance. This study was funded by the Ministry of Business, Innovation and Employment (C11X1312), New Zealand.

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Correspondence to Gunaranjan Paturi.

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The authors declare no conflict of interest.

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Paturi, G., Butts, C.A. & Bentley-Hewitt, K.L. Influence of Dietary Avocado on Gut Health in Rats. Plant Foods Hum Nutr 72, 321–323 (2017). https://doi.org/10.1007/s11130-017-0614-5

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Keywords

  • β-defensins
  • Gene expression
  • Goblet cells
  • Microbiota
  • Mucin
  • Plant-based foods