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Tea Dietary Fiber Improves Serum and Hepatic Lipid Profiles in Mice Fed a High Cholesterol Diet

Abstract

Tea dietary fiber (TDF) was prepared from tea residues and modified to get cellulose-modified TDF (CTDF) by cellulase or micronized TDF (MTDF) by ultrafine grinding. The in vitro lipid-binding capacities of the three fibers and their effects on serum and hepatic lipid profiles in mice fed a high cholesterol diet were evaluated. The results showed that the three fibers had excellent lipid-binding capacities, and the cholesterol- and sodium cholate-binding capacities of CTDF and MTDF were significantly higher than those of TDF. Animal studies showed that, compared to model control, the three fibers significantly decreased mice average daily gain, gain: feed, and liver index, reduced total cholesterol (TC), triglyceride, and low density lipoprotein-cholesterol of serum and liver, increased serum and hepatic high density lipoprotein-cholesterol to TC ratio, and promoted the excretion of fecal lipids, and they also significantly increased the activities of superoxide dismutase and glutathione peroxidase of serum and liver, and decreased lipid peroxidation; moreover, the effects of CTDF and MTDF were better than that of TDF. It was concluded that the three fibers could improve serum and hepatic lipid profiles in mice fed a high cholesterol diet and the mechanism of action might be due to the promotion of fecal excretion of lipids through their lipid-binding ability and the inhibition of lipid peroxidation. These findings suggest that tea dietary fiber has the potential to be used as a functional ingredient to control cardiovascular disease.

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Abbreviations

ADG:

Average daily gain

BW:

Body weight

CTDF:

Cellulase-modified tea dietary fiber

CVD:

Cardiovascular disease

DF:

Dietary fiber

GSH-Px:

Glutathione peroxidase

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

MC:

Model control

MDA:

Malondialdehyde

MTDF:

Micronized tea dietary fiber

SOD:

Superoxide dismutase

NC:

Normal control

TC:

Total cholesterol

TDF:

Tea dietary fiber

TG:

Triglyceride

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Acknowledgments

This work was financially supported by the Fundamental Research Funds for the Central Universities, China (grant no. 2013PY091) and the Natural Science Foundation of Hubei Province, China (grant no. 2011CDB136).

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Correspondence to Xiaoping Yang.

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Guo, W., Shu, Y. & Yang, X. Tea Dietary Fiber Improves Serum and Hepatic Lipid Profiles in Mice Fed a High Cholesterol Diet. Plant Foods Hum Nutr 71, 145–150 (2016). https://doi.org/10.1007/s11130-016-0536-7

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Keywords

  • Tea
  • Dietary fiber
  • Lipid profile
  • Antioxidant
  • Mice