Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits

Abstract

Artichoke (Cynara scolymus) leaf extract was one of the few herbal remedies which the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which corresponded with its historical use. Ongoing research seems to indicate that artichoke indeed have medicinal qualities. Most significant appears to be its beneficial effect on the liver. In animal studies, liquid extracts of the roots and leaves of artichoke have demonstrated an ability to protect the liver, with possibly even to help liver cells regenerate. Although research is not yet conclusive, scientists were optimistic that its long-standing use in humans for digestive and bowel problems was indeed justified. It may also play a role in lowering cholesterol and thus help to prevent heart disease. Boiled wild artichoke reduced postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. This article intended to review the wide ranging pharmacological effects of artichoke leaf extract.

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Abbreviations

ALE:

Artichaut leaf extract

C.scolymus :

Cynara scolymus

LDL-C:

Low density lipoprotein-cholesterol

DM:

Diabetes mellitus

NASH:

Non alcoholic steatohepatitis

References

  1. 1.

    Foti S, Mauromicale G, Raccuia SA, Fallico B, Fanella F, Maccarone E (1999) Possible alternative utilization of Cynara spp. I. Biomass, grain yield and chemical composition of grain. Ind Crop Prod 102:19–228

  2. 2.

    Portis E, Acquadro C, Comino G, Mauromicale ES, Lanteri S (2005) Genetic structure of island populations of wild cardoon [Cynara cardunculus L. var. sylvestris (Lamk) Fiori] detected by AFLPs and SSRs. Plant Sci 169:199–210

    CAS  Article  Google Scholar 

  3. 3.

    Ierna A, Mauromicale G (2010) Cynara cardunculus L. genotypes as a crop for energy purposes in a Mediterranean environment. Biomass Bioenergy 34:754–760

  4. 4.

    Sonnante G, Pignone D, Hammer K (2007) The domestication of artichoke and cardoon: from Roman times to the genomic age. Ann Bot 100:1095–1100

    Article  Google Scholar 

  5. 5.

    Lattanzio V, Paul AK, Lansalta V, Cardinali A (2009) Globe artichoke: a functional food and source of nutraceutical ingredients. J Funct Foods 1:131–144

    CAS  Article  Google Scholar 

  6. 6.

    Ceccarelli N, Curadi MP, Picciarelli L, Martelloni C, Sbrana MG (2007) Globe artichoke as functional food. Mediterr J Nutr Metab 31:97–201

    Google Scholar 

  7. 7.

    Pandino G, Lombardo S, Mauromicale G, Williamson G (2011) Profile of polyphenols and phenolic acids in bracts and receptacles of globe artichoke (Cynara cardunculus var. scolymus) germplasm. J Food Compos Anal 24:148–153

  8. 8.

    Gebhardt, Fausel M (1997) Antioxydant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Toxicol In Vitro 144:279–286

    CAS  Google Scholar 

  9. 9.

    Kraft K (1997) Artichoke leaf extract–recent findings reflecting effects on lipid metabolism, liver, and gastrointestinal tracts. Phytomedicine 43:69–78

    Google Scholar 

  10. 10.

    Bonomi BM (2001) La Rivista di Scienza dell’Alimentazione 30:361–370

  11. 11.

    Petrowicz O, Gebhardt R, Donne RM, Schwandt M, Kraft K (1997) Effects of artichoke leaf extract (ALE) on lipoprotein metabolism in vitro and in vivo. Atherosclerosis 129:147–150

  12. 12.

    Chang JJ, Appl K (2007) Radical scavenging activity and content of cynarin. Boil Chem 50:244–284

  13. 13.

    Robards K (2003) Strategies for determination of bioactive phenols in plants, fruit and vegetable. J Chromatgr 1000:657–691

  14. 14.

    Ceccarelli N, Curadi M, Picciarelli P, Martelloni L, Sbrana C, Giovannetti M (2010) Globe artichoke as functional food. Mediterr J Nutr Metab 3:197–201

    Article  Google Scholar 

  15. 15.

    Pandino G, Lombardo S, Mauromicale G, Williamson G (2011) Phenolic acids and flavonoids in leaf and floral stem of cultivated and wild Cynara cardunculus L. genotypes. Food Chem 126:417–422

  16. 16.

    Wang M, Simon JE, Aviles IF, Zheng HeK QY, Tadmor Y (2003) Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J Agric Food Chem 51:601–608

  17. 17.

    Llorach R, Espin JC, Toma-Barberan FA, Ferrere F (2002) Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics. J Agric Food Chem 50:3458–3464

    CAS  Article  Google Scholar 

  18. 18.

    Zhu X, Zhang H, Lo R (2004) Phenolic compounds from the leaf extract of artichoke (Cynara Scolymus L.) and their antimicrobial activities. J Agric Food Chem 52:7272–7278

  19. 19.

    Mossi AJ, Echeverrigaray S (1999) Identification and characterization of antimicrobial components in leaf extracts of globe artichoke (Cynara scolymus L.). Acta Horticult 501:111–114

  20. 20.

    Merck (2006) The Merck index 14th ed. an encyclopaedia of chemicals, drugs and biologicals. Merck Manuals, NJ

    Google Scholar 

  21. 21.

    Dorn M (1995/1996) Improvement in raised lipid levels with artichoke juice (Cynara scolymus L.). Br J Phytother 4:21–26

  22. 22.

    Liorach R, Espin JC, Tomas-Barberan FA, Ferreres F (2002) Artichoke byproducts as a potential source of health-promoting antioxidant phenolics. J Agric Food Chem 50:58–64

    Google Scholar 

  23. 23.

    Gebhardt R (1997) Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol 144:279–286

    CAS  Article  Google Scholar 

  24. 24.

    McDougall B, King PJ, Wu BW, Hostomsky Z, Reinecke MG, Robinson WE (1998) Dicaffeoylquinic and dicaffeoyltartaric acids were selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother 42:140–146

    CAS  Google Scholar 

  25. 25.

    Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N, Kandhro GA (2008) Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 122:1–18

    CAS  Article  Google Scholar 

  26. 26.

    Moon YS, Kashyap ML (2004) Pharmacologic treatment of type 2 diabetic dyslipidemia. Pharmacotherapy 241:692–1713

    Google Scholar 

  27. 27.

    Gupta S, Kataria M, Gupta PK, Murganandan S, Yashroy RC (2004) Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethnopharmacol 90:185–189

  28. 28.

    Vats V, Grover JK, Rathi SS (2002) Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J Ethnopharmacol 79:95–100

    CAS  Article  Google Scholar 

  29. 29.

    Mohammad A, Sahar N, Effat B (2013) Effet of Cynara scolymus on fasting blood sugar of rat. Int J Pharm Ind Res 3:180–182

  30. 30.

    Ahmadi MN, Madani H, Mahzoni P (2008) Hypoglycemic and hypolipdemic effet of hydro-alcoholic of Cynara scolymus L. extract in alloxan monohydrate-induced diabetes rats to compare with glibenclamide. Iran J Med Aromat Plants 40:148–161

  31. 31.

    Heckers H, Dittmar K, Schmahl FW, Huth K (1977) Inefficiency of cynarin as therapeutic regimen in familial type II hyperlipoproteinaemia. Atherosclerosis 262:49–53

    Google Scholar 

  32. 32.

    Gebhardt R (1996) Inhibition of hepatic cholesterol biosynthesis by artichoke leaf extracts is mainly due to luteolin. Cell Biol Toxicol 10:89–150

    Google Scholar 

  33. 33.

    Frohlich E, Zigler W (1973) The lipid lowering effects of Cynara scolymus. Subsid Med 25:5–9

  34. 34.

    Samochowiec L, Wojcicki J, Kadykow M (1971) The influence of 1,5dicaffeoylquinic acid on serum lipids in the experimentally alcoholised rat. Panminerva Med 13:87–150

    CAS  Google Scholar 

  35. 35.

    Wojcicki J (1976) Effect of 1,5-dicaffeoylquinic acid on ethanol-induced hypertriglyceridemia. Short communication. Arzneimittelforschung 26:20–47

    Google Scholar 

  36. 36.

    Samochowiec L (1959) Investigations on experimental atherosclerosis. The effect of Cynara scolymus L. and Cynara cardunculus L. on the development of experimental atherosclerosis in white rats. Diss Pharmacother 11:99–200

  37. 37.

    Lietti A (1977) Choleretic and cholesterol lowering properties of two artichoke extracts. Fitoterapia 48:153–300

    CAS  Google Scholar 

  38. 38.

    Bundy R, Walker AF, Middleton RW, Marakis JC, Booth G (2004) Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia. J Altern Complement Med 10:667–669

    Article  Google Scholar 

  39. 39.

    Englisch W, Beckers C, Unkauf M, Ruepp MV, Zinserling (2000) Efficacy of artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung 50:260–265

  40. 40.

    Esfandiar HS, Yadollah (2011) Hypolipidemic and hypoglycemic effects of aerial part of Cynara scolymus in streptozotocin-induced diabetic rats. J Med Plants Res 52:717–2723

    Google Scholar 

  41. 41.

    Gebhardt (2002) Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts was reinforced by glucosidase pretreatment. Phytother Res 16:368–372

    CAS  Article  Google Scholar 

  42. 42.

    Mangola EN (1990) Use of traditional medicines in diabetics mellitus. Diabetes Care 10:138–12

    Google Scholar 

  43. 43.

    Easwaran PU, Mageshwari, Narayanan G (1991) Therapeutic use of globe artichoke in non – insulin dependent diabetes mellitus and hypercholesterolemia. Ind J Nutr Dietet 28:321–326

    Google Scholar 

  44. 44.

    Kulza M, Adamska K, Seńczuk-Przybyłowska M et al (2010) Globe artichokes and the liver. Phytomedecine 69:1122–1126

    Google Scholar 

  45. 45.

    Gaafar AA, Salma ZA (2013) Phenolic compounds from artichoke (Cynara scolymus L.) byproducts and their antimicrobial activities. J Biol Agric Healthcare 12:2224–3208

  46. 46.

    Koubaa J, Damak M et al (1999) Constituents of Cynara cardunculus. Fitoterapia 70:212–213

  47. 47.

    Kameswara RB, Renuka SP, Rajasekhar MD, Nagaraju N, Appa RC (2003) Antidiabetic activity of Terminalia pallida fruit in alloxan induced diabetic rats. J Ethnopharmacol 85:169–172

    Article  Google Scholar 

  48. 48.

    Behara YB, Pharm B (2011) Pharmacological studies on artichoke leaf extract -an edible herb of Mediterranean origin. J Pharmaceut Biomed Sci 15:111–600

  49. 49.

    Gebhardt R (1995) Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol 144:279–286

  50. 50.

    Samochowiec L (1959) Investigations on experimental atherosclerosis. Part XV. The effect of Cynara scolymus L and Cynara cardunculus L on the development of experimental atherosclerosis in white rats Dissertationes. Pharmaceutica 11:99–13

  51. 51.

    Goldberg RB (1981) Lipid disorders in diabetes. Diabetes Care 45:61–572

    Google Scholar 

  52. 52.

    Adzet T, Camarasa J, Laguna JC (1987) Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. J Nat Prod 50:612–617

    CAS  Article  Google Scholar 

  53. 53.

    Adzet T (1987) Action of an artichoke extract against carbon tetrachloride-induced hepatotoxicity in rats Acts. Pharm Jugosl 37:183–188

    CAS  Google Scholar 

  54. 54.

    Betancor-Fernandez A, Perez-Galvez A, Sies H, Stahl W (2003) Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil’s claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol 55:981–986

    CAS  Article  Google Scholar 

  55. 55.

    Visioli P, Bogani S, Grande V, Detopoulou Y, Manios C, Galli (2006) Local food and cardioprotection: the role of phytochemicals. Forum Nutr 59:116–129

    Article  Google Scholar 

  56. 56.

    Zapolska-Downar D, Zapolski-Downar A, Naruszewicz M, Siennicka A, Krasnodebska B, Koldziej B (2002) Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci 71:2897–08

    CAS  Article  Google Scholar 

  57. 57.

    Brown J, Rice EC (1998) Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radic Res 29:247–255

    CAS  Article  Google Scholar 

  58. 58.

    Perez-Garcia F, Adzet T, Caniqueral S (2000) Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radic Res 33:661–665

    CAS  Article  Google Scholar 

  59. 59.

    Valerio F, De Bellis P, Lonigro SL, Morelli L, Visconti A, Lavermicocca P (2006) In vitro and in vivo survival and transit tolerance of potentially probiotic strains carried by artichokes in the gastrointestinal tract. Appl Environ Microbiol 72:3042–3045

    CAS  Article  Google Scholar 

  60. 60.

    Matuschowski JP (1996) Testing of Cynara scolymus in the isolated perfused rat liver. 43rd Ann Congr Soc Med Plant Res 10:103–107

    Google Scholar 

  61. 61.

    Demma J, Engidawork E, Hellman B (2009) Potential genotoxicity of plant extracts used in Ethiopian traditional medicine. J Ethnopharmacol 122:136–142

    CAS  Article  Google Scholar 

  62. 62.

    Rodrigues CRF, Dias JH, Semedo JG, Silva J, Ferraz JN, Picada (2009) Mutagenic and genotoxic effects of Baccharis dracunculifolia (D.C.). Ethnopharmacol 124:321–400

    Article  Google Scholar 

  63. 63.

    Jacociunas LV, Rodrigues d’Andrade HH, Lehmann M, Pedersini LW (2013) Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alteration in CHO cells. Phytomedicine 20:1131–1134

  64. 64.

    Nadova E, Miadokova P, Mucaji D, Grancai LC (2008) Growth inhibitory effect of ethyl acetate-soluble fraction of Cynara cardunculus L. in leukemia cells involves cell arrest, cytochrome c release and activiation of caspases. Phytother Res 22:165–800

  65. 65.

    Paschos P, Paletas K (2009) Non-alcoholic fatty liver disease and metabolic syndrome. Hippokratia 10:19–19

    Google Scholar 

  66. 66.

    Preiss D, Sattar N (2008) Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci 115:141–150

    CAS  Article  Google Scholar 

  67. 67.

    Safaa HM, Hanaa HA, Abdelrazik HF, Nahla SA, Abdelaaty AS (2013) Cynara scolymus for relieving on nonalcoholic steatohepatitis induced in rats. Int J Pharm Pharm Sci 1:57–66

    Google Scholar 

  68. 68.

    Volker S, Rudolf H, Rational Phytotherapy (2004) A reference guide for physicians and pharmacists by springer 417:232–240

  69. 69.

    Ernst E, De Smet PA , Shaw D, Muraay V (1998) Traditional remedies and the test of time. Eur J Clin Pharmacol 54:99–100

    CAS  Article  Google Scholar 

  70. 70.

    Wittemer SM, Ploch M, Windeck T, Muller SC, Drewelow B, Derendorf et al (2005) Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of artichoke leaf extracts in humans. Phytomedicine 12(28):38

  71. 71.

    Fotis S, Mauramicale G, Raccuia SA, Fallico B, Fanella E, Maccarone E (1999) Possible alternative utilization of Cynara spp. I. Biomass, grain yield and chemical composition of grain. Ind Crop Prod 10:219–228

  72. 72.

    Fintelman V (1996) Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties. Phytomedica 201:50–60

  73. 73.

    Schulz H, Rudolf (2004) Rational phototherapy: a reference guide for physicians and pharmacists. Springer 11:232–417

    Google Scholar 

  74. 74.

    Meneses M, Megias MD, Madrid J, Martinez-Teruel A, Hernandez F, Oliva J (2007) Evaluation of the phytosanitary, fermentative and nutritive characteristics of the silage made from crude artichoke (Cynara scolymus L.) by-product feeding for ruminants. Phytomedecine 70:292–296

  75. 75.

    Gasa J, Castrillo C, Baucells MD, Guada JA (1989) By-products from the canning industry as feedstuff for ruminants, digestibility and its prediction from chemical composition and laboratory bioassays. Anim Feed Sci Technol 25:67–77

    Article  Google Scholar 

  76. 76.

    Marsico G, Vicenti A, Ragni M, Laudadio V, Lestingi A, Vonghi G (1999) The use of artichoke (Cynara scolymus L.) bracts in lambs feeding. Effect on productive performances and quanti-qualitative traits of carcasses and meat. Agricoltura Ricerca 21:39–48

  77. 77.

    Jaramillo DP, Buffa MN, Rodriguez M, Perez-Baena I, Guamis B, Trujillo AJ (2010) Effect of the inclusion of artichoke silage in the ration of lactating ewes on the properties of milk and cheese characteristics during ripening. J Dairy Sci 93:1412–1419

    CAS  Article  Google Scholar 

  78. 78.

    Sallam S, Bueno MA, Godoy ICS, Nozella PB, Vitti EF, Abdalla DM (2008) Nutritive value assessment of the artichoke (Cynara scolymus) by-product as an alternative feed resource for ruminants. Trop Subtrop Agroecosyst 8:181–189

    Google Scholar 

  79. 79.

    Costabile A, Kolida S, Klinder A, Gietl E, Bauerlein M, Frohberg C, Landschutze V, Gibson GR (2010) A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a verylong-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects. Br J Nutr 104:1007–1017

    CAS  Article  Google Scholar 

  80. 80.

    Williamson G, Manach C (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81:243–255

    Google Scholar 

  81. 81.

    Clifford M, Brown JE (2006) Dietary flavonoids and health, broadening the perspective. In: Andersen O, Markham K (eds) Flavonoids: chemistry, biochemistry and applications. CRC Press, Boca Raton, FL pp 10,450–600

  82. 82.

    Brown JE, Rice-Evans CA (1980) Luteolin-rich artichoke extracts protects low density lipoproteins from oxidation in vitro. Free Radic Res 29:247–255

    Article  Google Scholar 

  83. 83.

    Kucukgergin C, Aydin AF, Ozdemirler GO, Mehmetcik G, Kocar-Toker N, Uysal M (2010) Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet. Biol Trace Elem Res 135:264–274

    CAS  Article  Google Scholar 

  84. 84.

    Stoev SD (2010) Studies on some feed additives and materials giving partial protection against the suppressive effect of ochratoxin A on egg production of laying hens. Res Vet Sci 88, 486–491. 91

  85. 85.

    Stoev SD, Anguelov G, Ivanov I, Pavlov D (2000) Influence of ochratoxin A and an extract of artichoke on the vaccinal immunity and health in broiler chicks. Exp Toxicol Pathol 52:43–55

    CAS  Article  Google Scholar 

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The authors declare that they  have no conflict of interest.

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Salem, M.B., Affes, H., Ksouda, K. et al. Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. Plant Foods Hum Nutr 70, 441–453 (2015). https://doi.org/10.1007/s11130-015-0503-8

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Keywords

  • Artichoke leaves extract
  • Cardiovascular disorders
  • Antioxidant
  • Hepato-protective