Abstract
Our results affirmed that supplementation of 1 or 2 % mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7α-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1.
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Acknowledgments
This project was supported by the Program for International S & T Cooperation Projects (S2013HT0015L) from Ministry of P. R. China, earmarked fund for China Agriculture Research System Modern Agro-industry Technology (CYTX-018) and Sci & Tech Innovation Program of CAAS.
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The authors have declared no conflicts of interest.
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Yao, Y., Hao, L., Shi, Z. et al. Mung Bean Decreases Plasma Cholesterol by Up-regulation of CYP7A1. Plant Foods Hum Nutr 69, 134–136 (2014). https://doi.org/10.1007/s11130-014-0405-1
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DOI: https://doi.org/10.1007/s11130-014-0405-1