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Anti-inflammatory Properties of Orange Juice: Possible Favorable Molecular and Metabolic Effects

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Abstract

The low-grade inflammation has been recognized as the link between adiposity and the risk of chronic metabolic disorders. Thus, increased concentrations of inflammatory markers, such as interleukins and tumor necrosis factor alpha have been found in obese individuals. In turn, diet can positively or negatively influence on the risk of chronic metabolic diseases by modulating the inflammatory status. In this context, orange juice consumption can play a role in modulation of inflammatory markers through bioactive compounds, such as the flavonoids (hesperidin, naringenin). According to this review, orange juice appears to mediate the inflammatory response in plasma level and gene expression, and in postprandial and chronic (≥7 consecutive days) periods. The current findings suggest that orange juice could be a dietary feature for prevention and treatment of chronic diseases, although more studies are necessary to evaluate the physiological and molecular mechanisms involved.

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Abbreviations

BP:

Blood pressure

CVD:

Cardiovascular disease

CD-14:

Cluster differentiation 14

CRP:

C-reactive protein

COX2:

Cyclooxygenase-2

DNA:

Deoxyribonucleic acid

DBP:

Diastolic blood pressure

FFA:

Free fatty acids

GLUT4:

Glucose transporter type 4

GST:

Glutathione S-transferase

HFHC:

High-carbohydrate

IL1R1:

IL-1 receptor 1

Iκβ:

Inhibitor κβ

ICAM-1:

Intercellular adhesion molecule-1

IL:

Interleukin

JNK:

Janus kinase

LPB:

Lipopolysaccharide binding protein

LPS:

Lipopolysaccharide

MMP-9:

Matrix metalloproteinase-9

METs:

Metabolic syndrome

MCP-1:

Monocyte chemoattractant protein-1

NRF2:

NF-E2-related factor 2

NO:

Nitric oxide

NF-κβ:

Nuclear factor kappa-B

OJ:

Orange juice

PBMC:

Peripheral blood mononuclear cells

PAI-1:

Plasminogen activator inhibitor-1

QR:

Quinone reductase

ROS:

Reactive oxygen species

SOCS3:

Suppresser of cytokine signaling-3

TLR:

Toll-like receptors

TNFα:

Tumor necrosis factor alpha

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  1. Department of Nutrition and Healthy, Federal University of Viçosa, Avenida PH Rolfs s/n, Campus Universitário, 36571-000, Viçosa, Minas Gerais, Brazil

    Raquel Cristina Lopes Assis Coelho, Helen Hermana M. Hermsdorff & Josefina Bressan

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  1. Raquel Cristina Lopes Assis Coelho
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  2. Helen Hermana M. Hermsdorff
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Correspondence to Raquel Cristina Lopes Assis Coelho.

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Coelho, R.C.L.A., Hermsdorff, H.H.M. & Bressan, J. Anti-inflammatory Properties of Orange Juice: Possible Favorable Molecular and Metabolic Effects. Plant Foods Hum Nutr 68, 1–10 (2013). https://doi.org/10.1007/s11130-013-0343-3

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