Anti-inflammatory Properties of Orange Juice: Possible Favorable Molecular and Metabolic Effects


The low-grade inflammation has been recognized as the link between adiposity and the risk of chronic metabolic disorders. Thus, increased concentrations of inflammatory markers, such as interleukins and tumor necrosis factor alpha have been found in obese individuals. In turn, diet can positively or negatively influence on the risk of chronic metabolic diseases by modulating the inflammatory status. In this context, orange juice consumption can play a role in modulation of inflammatory markers through bioactive compounds, such as the flavonoids (hesperidin, naringenin). According to this review, orange juice appears to mediate the inflammatory response in plasma level and gene expression, and in postprandial and chronic (≥7 consecutive days) periods. The current findings suggest that orange juice could be a dietary feature for prevention and treatment of chronic diseases, although more studies are necessary to evaluate the physiological and molecular mechanisms involved.

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Fig. 1
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Fig. 3



Blood pressure


Cardiovascular disease


Cluster differentiation 14


C-reactive protein




Deoxyribonucleic acid


Diastolic blood pressure


Free fatty acids


Glucose transporter type 4


Glutathione S-transferase




IL-1 receptor 1


Inhibitor κβ


Intercellular adhesion molecule-1




Janus kinase


Lipopolysaccharide binding protein




Matrix metalloproteinase-9


Metabolic syndrome


Monocyte chemoattractant protein-1


NF-E2-related factor 2


Nitric oxide


Nuclear factor kappa-B


Orange juice


Peripheral blood mononuclear cells


Plasminogen activator inhibitor-1


Quinone reductase


Reactive oxygen species


Suppresser of cytokine signaling-3


Toll-like receptors


Tumor necrosis factor alpha


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Correspondence to Raquel Cristina Lopes Assis Coelho.

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Coelho, R.C.L.A., Hermsdorff, H.H.M. & Bressan, J. Anti-inflammatory Properties of Orange Juice: Possible Favorable Molecular and Metabolic Effects. Plant Foods Hum Nutr 68, 1–10 (2013).

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  • Orange juice
  • Hesperidin
  • Naringenin
  • Inflammation
  • Gene expression
  • Nutrigenomic