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Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats

Plant Foods for Human Nutrition volume 64, pages 75–80 (2009)Cite this article

Abstract

The present study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid peroxidation, endogenous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO (200 mg/kg, s.c.) for 2 days at an interval of 24 h caused a significant (P < 0.05) elevation of heart weight, serum marker enzymes, lipid peroxidation and Ca+2 ATPase level whereas there was a significant (P < 0.05) decrease in body weight, endogenous antioxidants, Na+/ K+ ATPase and Mg+2 ATPase levels. Administration of green tea (100 mg/kg/day, p.o.) and vitamin E (100 mg/kg/day, p.o.) together for 30 consecutive days and challenged with ISO on the day 29th and 30th, showed a significant (P < 0.05) decrease in heart weight, serum marker enzymes, lipid peroxidation, Ca+2 ATPase and a significant increase in the body weight, endogenous antioxidants, Na+/K+ ATPase and Mg+2 ATPase when compared with ISO treated group and green tea or vitamin E alone treated groups. These findings indicate the synergistic protective effect of green tea and vitamin E during ISO induced myocardial infarction in rats.

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Authors and Affiliations

  1. Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, 390 002, Gujarat, India

    Aman Upaganlawar, Chintan Gandhi & Ramchandran Balaraman

  2. Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Kalabhavan, Vadodara, 390001, Gujarat, India

    Ramchandran Balaraman

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  1. Aman Upaganlawar
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  2. Chintan Gandhi
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Correspondence to Ramchandran Balaraman.

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Upaganlawar, A., Gandhi, C. & Balaraman, R. Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats. Plant Foods Hum Nutr 64, 75–80 (2009). https://doi.org/10.1007/s11130-008-0105-9

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