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Ingestion of Black Chokeberry Fruit Extract Leads to Intestinal and Systemic Changes in a Rat Model of Prediabetes and Hyperlipidemia

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Abstract

This report presents a complex analysis of changes proceeding in the gut, blood and internal organs of rats with induced oxidative stress, glucose intolerance and hyperlipidemia after dietary supplementation with an extract from black chokeberry (Aronia melanocarpa) fruit, that is a condensed source of polyphenols (714 mg/g), especially anthocyanin glycosides (56.6%). The disturbances mimicking those observed in metabolic syndrome were induced by a high-fructose diet and simultaneous single injection of streptozotocin (20 mg/kg). Dietary supplementation with the chokeberry fruit extract (0.2%) decreased activity of maltase and sucrase as well as increased activity of lactase in the mucosa of the small intestine. Its ingestion led also to the improvement of antioxidant status, especially, the concentration of a lipid peroxidation indicator (TBARS) in organ tissues (liver, kidney and lung) was normalized; some cholesterol-lowering and distinct hypoglycemic actions were also observed. The mechanism of glucose reduction is likely to be multifactorial, and we suggest the factors related with the decreased activity of mucosal disaccharidases important for further investigation. In conclusion, chokeberry fruit derivatives may act as a promising supplementary therapeutic option in the prevention and treatment of disorders occurring in metabolic syndrome, as well as their complications.

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Abbreviations

ACL:

antioxidant capacity of lipophilic substances

ACH:

antioxidant capacity of hydrophilic substances

STZ:

streptozotocin

GPx:

glutathione peroxidase

HDL:

high-density lipoprotein

SCFA:

short-chain fatty acids

SOD:

superoxide dismutase

TBARS:

thiobarbituric acid-reactive substances

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Authors and Affiliations

  1. Department of Biological Analysis of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747, Olsztyn, Poland

    Adam Jurgoński, Jerzy Juśkiewicz & Zenon Zduńczyk

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  1. Adam Jurgoński
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  2. Jerzy Juśkiewicz
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  3. Zenon Zduńczyk
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Correspondence to Adam Jurgoński.

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Jurgoński, A., Juśkiewicz, J. & Zduńczyk, Z. Ingestion of Black Chokeberry Fruit Extract Leads to Intestinal and Systemic Changes in a Rat Model of Prediabetes and Hyperlipidemia. Plant Foods Hum Nutr 63, 176–182 (2008). https://doi.org/10.1007/s11130-008-0087-7

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  • DOI: https://doi.org/10.1007/s11130-008-0087-7

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