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Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats

Abstract

Bitter gourd (Momordica charantia), a commonly consumed vegetable is used as an adjunct in the management of diabetes mellitus. A study was carried out to examine the effect of edible portion of bitter gourd at 10% level in the diet in streptozotocin induced diabetic rats. To evaluate the glycaemic control of bitter gourd during diabetes, diet intake, gain in body weight, water intake, urine sugar, urine volume, glomerular filtration rate and fasting blood glucose profiles were monitored. Water consumption, urine volume and urine sugar were significantly higher in diabetic controls compared to normal rats and bitter gourd feeding alleviated this rise during diabetes by about 30%. Renal hypertrophy was higher in diabetic controls and bitter gourd supplementation, partially, but effectively prevented it (38%) during diabetes. Increased glomerular filtration rate in diabetes was significantly reduced (27%) by bitter gourd. An amelioration of about 30% in fasting blood glucose was observed with bitter gourd feeding in diabetic rats. These results clearly provided experimental evidence that dried bitter gourd powder in the diet at 10% level improved diabetic status signifying its beneficial effect during diabetes.

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Abbreviations

BFC:

Bitter gourd fed control

BFD:

Bitter gourd fed diabetic

GFR:

Glomerular filtration rate

SFC:

Starch fed control

SFD:

Starch fed diabetic

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Correspondence to P. V. Salimath.

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Shetty, A.K., Kumar, G.S., Sambaiah, K. et al. Effect of Bitter Gourd (Momordica charantia) on Glycaemic Status in Streptozotocin Induced Diabetic Rats. Plant Foods Hum Nutr 60, 109–112 (2005). https://doi.org/10.1007/s11130-005-6837-x

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  • DOI: https://doi.org/10.1007/s11130-005-6837-x

Key words

  • Bitter gourd
  • Diabetes
  • Fasting blood glucose
  • Glomerular filtration rate
  • Urine sugar