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Calmodulin7: recent insights into emerging roles in plant development and stress

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Abstract

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Analyses of the function of Arabidopsis Calmodulin7 (CAM7) in concert with multiple regulatory proteins involved in various signal transduction processes.

Abstract

Calmodulin (CaM) plays various regulatory roles in multiple signaling pathways in eukaryotes. Arabidopsis CALMODULIN 7 (CAM7) is a unique member of the CAM family that works as a transcription factor in light signaling pathways. CAM7 works in concert with CONSTITUTIVE PHOTOMORPHOGENIC 1 and ELONGATED HYPOCOTYL 5, and plays an important role in seedling development. Further, it is involved in the regulation of the activity of various Ca2+-gated channels such as cyclic nucleotide gated channel 6 (CNGC6), CNGC14 and auto-inhibited Ca2+ ATPase 8. Recent studies further indicate that CAM7 is also an integral part of multiple signaling pathways including hormone, immunity and stress. Here, we review the recent advances in understanding the multifaceted role of CAM7. We highlight the open-ended questions, and also discuss the diverse aspects of CAM7 characterization that need to be addressed for comprehensive understanding of its cellular functions.

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Funding

This work is supported by J.C. Bose National Fellowship Award Grant of SERB, Government of India to S.C. R.B. and A.P. are recipients of CSIR-JRF from Council of Scientific and Industrial Research (CSIR), Government of India.

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  1. Siddhartha Dutta

    Present address: Department of Biotechnology, University of Engineering and Management, University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India

  2. Riya Basu and Siddhartha Dutta have contributed equally.

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  1. Department of Biotechnology, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, West Bengal, 713209, India

    Riya Basu, Siddhartha Dutta, Abhideep Pal, Mandar Sengupta & Sudip Chattopadhyay

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Contributions

RB, SD, and SC conceived and designed the review. SD extracted and analyzed the GO enrichment, KEGG pathway and Genevestigator expression data. RB, SD, AP, MS, and SC wrote the manuscript.

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Correspondence to Sudip Chattopadhyay.

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Supplementary Information

Below is the link to the electronic supplementary material.

Supplemental Data 1. NetPhos 3.1a predicted phosphorylation sites for CAM7. Supplementary file1 (XLSX 9 kb)

11103_2021_1177_MOESM2_ESM.xlsx

Supplemental Data 2. List of CAM7 interacting proteins (CAM7-IPs) and overviews of GO and KEGG pathways analysis. Supplementary file2 (XLSX 24 kb)

11103_2021_1177_MOESM3_ESM.xlsx

Supplemental Data 3. List of Cis-acting regulatory elements (CREs) retrieved from PLACE database analysis of CAM7 promoter sequence. Supplementary file3 (XLSX 15 kb)

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Basu, R., Dutta, S., Pal, A. et al. Calmodulin7: recent insights into emerging roles in plant development and stress. Plant Mol Biol 107, 1–20 (2021). https://doi.org/10.1007/s11103-021-01177-1

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