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Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review

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Abstract

Purpose

In the past few decades, acromegaly and colonic polyps have been associated with an increased risk of colorectal cancer. Previous studies highlighted the importance of serum biomarkers of colonic polyps in patients with acromegaly.

Methods

We reviewed studies on serum biomarkers of colonic polyps in patients with acromegaly, published on PubMed, Embase, Cochrane Library, Medline, and Chinese databases from January 1, 1966, to May 8, 2022. Meta-analysis and systematic review were conducted using Stata MP 14.0.

Results

Eight articles were included in this study. The mean (standard deviation) concentrations of serum biomarkers for acromegaly with and without colorectal polyps were extracted from these studies. Meta-analysis results showed that, compared to patients without colonic polyps, the levels of insulin-like growth factor-1 × upper limit of normal range (IGF-1 × ULN) and fasting insulin were significantly increased; while the levels of growth hormone (GH) were significantly decreased in patients with acromegaly and colonic polyps (IGF-1 × ULN: SMD 0.23; 95% CI 0.03–0.42, p < 0.05) (fasting insulin: SMD 0.95; 9 5% CI 0.11–1.8, p < 0.05) (GH: SMD − 0.25; 95% CI − 0.41 to − 0.08, p < 0.05). IGF-1 and FPG levels did not differ significantly (IGF-1: SMD -0.03; 95% CI − 0.22 to 0.17, p > 0.05) (FPG: SMD 0.14; 95% CI − 0.23 to 0.52, p > 0.05). The systematic review results suggest no significant differences in hemoglobin A1C, TSH, free thyroxine, FT4, T3, PRL, total cholesterol, HDL, LDL, fibrinogen, clathrate antigen, serum antigen 19-9, and α-fetoprotein levels, but serum Klotho levels.

Conclusion

We present the first meta-analysis and systematic review of serum biomarkers in patients with acromegaly or colonic polyps. The prevalence of colonic lesion polyps, is associated with higher IGF-1 × ULN levels, higher insulin levels in acromegaly. Further research is required to confirm GH and serum soluble Klotho levels as biomarkers of colonic polyps. When IGF-1 × ULN, fasting insulin levels change in patients with acromegaly, the occurrence of colonic polyps should be monitored. Early detection may reduce the possibility of developing malignant colon neoplasms.

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Data availability

Detailed data have been shown in the supplementary materials. Data sharing not applicable to this article.

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Acknowledgements

We thank corresponding authors who contributed with additional data from primary studies that were not available in the original articles.

Funding

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China

    Xiaoyu Ji, Xiaozhe Li, Kun Yuan & Xuebo Sun

  2. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    Jiajia Fu

  3. Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

    Qiaoling Yao

  4. National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology, Tianjin Medical University, Tianjin, China

    Qiaoling Yao

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  1. Xiaoyu Ji
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Contributions

XJ conceived the study. XJ and JF contributed to the literature search, data curation, data collection, formal analysis, manuscript preparation and writing. XL and KY contributed to manuscript preparation and writing. QY contributed to the review and data collection. XS contributed to the review, editing and scientific research thinking and methods. All authors have read and approved the manuscript.

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Correspondence to Xuebo Sun or Qiaoling Yao.

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Ji, X., Fu, J., Li, X. et al. Serum biomarkers of colonic polyps in patients with acromegaly: a meta-analysis and systematic review. Pituitary 26, 1–8 (2023). https://doi.org/10.1007/s11102-022-01287-z

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