Abstract
In this brief report, we review the unique characteristics of Cushing disease (CD) in children, as well as the most important new genetic discoveries associated with childhood CD. We often forget it, but CD refers to Cushing syndrome caused by pituitary corticotroph adenomas only. Thus, here we only refer to the new discoveries associated with pituitary tumors. There is indeed a wealth of new information on clinical features, outcomes, and genetic determinants of CD in children!
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Acknowledgements
I want to thank the Cushing’s protocol team at the NIH Warren Magnuson Clinical Center that assisted me there for 26 years (1995–2021). Drs. Keil, Lodish and Tatsi among many others were instrumental in the success of our studies. I also want to express my gratitude to our patients and their families that participated and supported our research. Funding for these studies was provided by the intramural program of NICHD, NIH, Bethesda, MD20892, USA.
Funding
This work was funded in part by the intramural program of NICHD, NIH, Bethesda, MD, USA and the IMBB, FORTH, Heraklion, Crete, Greece, in addition to the ELPEN Research Institute, Athens, Greece.
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Stratakis, C.A. Cushing’s disease in children: unique features and update on genetics. Pituitary 25, 764–767 (2022). https://doi.org/10.1007/s11102-022-01237-9
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DOI: https://doi.org/10.1007/s11102-022-01237-9