Abstract
Introduction
Follow-up management of patients with acromegaly after pituitary surgery is performed by conducting biochemical assays of growth hormone (GH) and insulin-like growth factor-1 (IGF1). Despite concordant results of these two tests in the majority of cases, there is increasing recognition of patients who show persistent or intermittent discordance between GH and IGF1 (normal GH and elevated IGF1 or vice versa).
Method
In this narrative review, the last three decades materials on the issue of discrepancy between GH and IGF1 were thoroughly assessed.
Results
Various studies have obtained different discordance rates, ranging from 5.4 to 39.5 %. At present, despite the use of current sensitive assays and more stringent criteria to define remission, the rate of discordance still remains high. A number of mechanisms have been proposed to explain the postoperative discordance of GH and IGF1 including; altered dynamics of the GH secretion after surgery, early postoperative hormone assay, inaccurate or less sensitive tests and laboratory errors, too high cut-off point for GH suppression in the GH assays, GH nadir values not adjusted to age, sex, and body mass index, the influence of concomitant medication, co-existing physiologic and pathologic conditions, and many other proposed reasons. Nevertheless, the underlying mechanisms are still far from clear, and the solution continues to evade complete elucidation. Similarly, the impacts of such a discrepancy over mortality and morbidity and the risk of biochemical and/or clinical recurrence are unclear.
Conclusion
As a challenging clinical problem, a stepwise evaluation and management of these patients appears to be more rational.
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References
Carmichael JD, Bonert VS, Mirocha JM, Melmed S (2009) The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly. J Clin Endocrinol Metab 94:523–527
Melmed S (2006) Medical progress: acromegal. N Engl J Med 355:2558–2573
Alexander L, Appleton D, Hall R, Ross WM, Wilkinson R (1980) Epidemiology of acromegaly in the Newcastle region. Clin Endocrinol 12:71–79
Wu T, Lin H, Lu R, Wang M, Chen R, Chen H (2010) The role of insulin-like growth factor-1 and growth hormone in the mortality of patients with acromegaly after trans-sphenoidal surgery. Growth Horm IGF Res 20:411–415
Holdaway IM, Rajasoorya C (1999) Epidemiology of acromegaly. Pituitary 2(1):29–41
Fleseriu M, Delashaw JB, Jr, Cook DM (2010) Acromegaly: a review of current medical therapy and new drugs on the horizon. Neurosurg Focus E15. doi:10.3171/2010.7.FOCUS10154
Cook DM, Ezzat S, Katznelson L, Kleinberg DL, Laws ER Jr, Nippoldt TB, Swearingen B, Vance ML (2004) AACE medical guidelines for clinical practice for the diagnosis and treatment of acromegaly. Endocr Pract 10(3):213–225
Swearingen B, Barker FG, Katznelson L, Biller BM, Grinspoon S, Klibanski A, Moayeri N, Black PM, Zervas NT (1998) Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly. J Clin Endocrinol Metab 83:3419–3426
Clemmons DR, Strasburger C (2004) Monitoring the response to treatment in acromegaly. J Clin Endocrinol Metab 89:5289–5291
Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF, Trainer P, Ghigo E, Ho K, Melmed S (2010) A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metab 95(7):3141–3148
Arafat AM, Möhlig M, Weickert MO, Perschel FH, Purschwitz J, Spranger J, Strasburger CJ, Schöfl C, Pfeiffer AF (2008) Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index. J Clin Endocrinol Metab 93:1254–1262
Kaltsas GA, Isidori AM, Florakis D, Trainer PJ, Camacho-Hubner C, Afshar F, Sabin I, Jenkins JP, Chew SL, Monson JP, Besser GM, Grossman AB (2001) Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity. J Clin Endocrinol Metab 86:1645–1652
Minuto F, Resmini E, Boschetti M, Arvigo M, Sormani MP, Giusti M, Ferone D, Barreca A (2004) Assessment of disease activity in acromegaly by means of a single blood sample: comparison of the 120th minute postglucose value with spontaneous GH secretion and with the IGF system. Clin Endocrinol 6:138–144
Clemmons DR (2007) Value of insulin-like growth factor system markers in the assessment of growth hormone status. Endocrinol Metab Clin North Am 36:109–129
Elias PCL, Lugao HB, Pereira M, Machado HR, de Castro M, Moreira AC (2010) Discordant nadir GH after oral glucose and IGF-ilevels on treated acromegaly: refining the biochemical markers of mild disease activity. Horm Metab Res 42:50–55
Ho KY, Weissberger AJ (1994) Characterization of 24-hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clin Endocrinol 41:75–83
Semer M, Faria AC, Nery M, Salgado LR, Knoepfelmacher M, Wajchenberg BL, Liberman B (1995) Growth hormone pulsatility in active and cured acromegaly subjects. J Clin Endocrinol Metab 80:767–3770
Freda PU (2003) Current concepts in the biochemical assessment of the patient with acromegaly. Growth Horm IGF Res 13:171–184
Duncan E, Wass JAH (1999) Investigation protocol: acromegaly and its Investigation. Clin Endocrinol 50:285–293
Brzana JA, Yedinak CG, Delashaw JB, Gultelkin HS, Cook D, Fleseriu M (2012) Discordant growth hormone and IGF-1 levels post pituitary surgery in patients with acromegaly naïve to medical therapy and radiation: what to follow, GH or IGF-1 values? Pituitary 15:562–570
Peacey SR, Shalet SM (2001) Insulin-like growth factor 1 measurement in diagnosis and management of acromegaly. Ann Clin Biochem 38:297–303
Karavitaki N, Fernandez A, Fazal-Sanderson V, Wass JAH (2009) The value of the oral glucose tolerance test, random serum growth hormone and mean growth hormone levels in assessing the postoperative outcome of patients with acromegaly. Clin Endocrinol 71:840–845
Bates AS, Evans AJ, Jones P, Clayton RN (1995) Assessment of GH status in acromegaly using serum growth hormone, serum insulin-like growth factor-1 and urinary growth hormone excretion. Clin Endocrinol 42:417–423
Dobrashian RD, O’Halloran DJ, Hunt A, Beardwell CG, Shalet SM (1993) Relationships between insulin-like growth factor-1 levels and growth hormone concentrations during diurnal profiles and following oral glucose in acromegaly. Clin Endocrinol 38:589–593
Sherlock M, Aragon Alonso A, Reulen RC, Ayuk J, Clayton RN, Holder G, Sheppard MC, Bates A, Stewart PM (2009) Monitoring disease activity using GH and IGF-I in the follow-up of 501 patients with acromegaly. Clin Endocrinol 71(1):74–81
Ben-Shlomo A, Sheppard MC, Stephens JM, Pulgar S, Melmed S (2011) Clinical, quality of life, and economic value of acromegaly disease control. Pituitary 14:284–294
Parkinson C, Ryder WDJ, Trainer PJ (2001) The relationship between serum GH and serum IGF-I in acromegaly is gender-specific. J Clin Endocrinol Metab 86:5240–5244
Mercado M, Espinosa de los Monteros AL, Sosa E, Cheng S, Mendoza V, Hernández I, Sandoval C, Guinto G, Molina M (2004) Clinical-biochemical correlations in acromegaly at diagnosis and the real prevalence of biochemically discordant disease. Horm Res 62:293–299
Feelders R, Bidlingmaier M, Strasburger CJ, Janssen JA, Uitterlinden P, Hofland LJ, Lamberts SW, van der Lely AJ, de Herder WW (2005) Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels. J Clin Endocrinol Metab 90(12):6480–6489
Brooke AM, Drake WM (2007) Serum IGF-I levels in the diagnosis and monitoring of acromegaly. Pituitary 10:173–179
Dall R, Longobardi S, Ehrnborg C, Keay N, Rosen T, Jorgensen JO, Cuneo RC, Boroujerdi MA, Cittadini A, Napoli R, Christiansen JS, Bengtsson BA, Sacca L, Baxter RC, Basset EE, Sonksen PH (2000) The effect of four weeks of supraphysiological growth hormone administration on the insulin-like growth factor axis in women and men. GH-2000 study group. J Clin Endocrinol Metab 85:4193–4200
Freda PU, Post KD, Powell JS, Wardlaw SL (1998) Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly. J Clin Endocrinol Metab 83:3808–3816
Costa AC, Rossi A, MartinelliJr CE, Machado HR, Moreira AC (2002) Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? J Clin Endocrinol Metab 87:3142–3147
Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML (2002) Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067–2079
Edling KL, Heaney AP (1994) An update on the treatment of acromegaly. Res Rep Endocr Disord 2013(3):1–11
Ribeiro-Oliveira A Jr, Faje AT, Barkan AL (2011) Limited utility of oral glucose tolerance test in biochemically active acromegaly. Eur J Endocrinol 164:17–22
Plöckinger U (2012) Medical therapy of acromegaly. Int J Endocrinol. doi:10.1155/2012/268957
Neggers SJCMM, Biermasz NR, van der Lely AJ (2012) What is active acromegaly and which parameters do we have? Clin Endocrinol 76:609–614
Freda PU, Nuruzzaman AT, Reyes CM, Sundeen RE, Post KD (2004) Significance of “abnormal” nadir growth hormone levels after oral glucose in postoperative patients with acromegaly in remission with normal insulin-like growth factor-I levels. J Clin Endocrinol Metab 89:495–500
Hepburn S, Chambers SM, Gilbert JA, McGregor AM, Miell JP, Aylwin SJB (2006) Concordance between GH determination and IGF-I in acromegaly using two IGF-I methods. Endocr Abstracts 11:191
Gullu S, Keles H, Delibasi T, Tonyukuk V, Kamel N, Erdogan G (2004) Remission criteria for the follow-up of patients with acromegaly. Eur J Endocrinol 150:465–471
Markkanen H, Pekkarinen T, Valimaki MJ, Alfthan H, Kauppinen-Makelin R, Sane T, Stenman UH (2006) Effect of sex and assay method on serum concentrations of growth hormone in patients with acromegaly and in healthy controls. Clin Chem 52:468–473
Colao A, Amato G, Pedroncelli AM, Baldelli R, Grottoli S, Gasco V, Petretta M, Carella C, Pagani G, Tambura G, Lombardi G (2002) Gender- and age-related differences in the endocrine parameters of acromegaly. J Endocrinol Invest 25:532–538
Arafat AM, Möhlig M, Weickert MO, Perschel FH, Purschwitz J, Spranger J, Strasburger CJ, Schöfl C, Pfeiffer AFH (2008) Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index. J Clin Endocrinol Metab 93:1254–1262
Massart C, Poirier JY (2006) Serum insulin-like growth factor-I measurement in the follow-up of treated acromegaly: comparison of four immunoassays. Clin Chim Acta 373:176–179
Clemmons DR (2011) Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays. Clin Chem 57:555–559
Dimaraki EV, Jaffe CA, Mott-Friberg R, Chandler WF, Barkan AL (2002) Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. J Clin Endocrinol Metab 87:3537–3542
Boero L, Manavela M, Danilowicz K, Alfieri A, Ballarino MC, Chervin A, Garcı′a-Basavilbaso N, Glerean M, Guitelman M, Loto MG, Nahmı′as JA, Rogozinski AS, Servidio M, Vitale NM, Katz D, Day PF, Stalldecker G, Mallea-Gil MS (2012) Comparison of two immunoassays in the determination of IGF-I levels and its correlation with oral glucose tolerance test (OGTT) and with clinical symptoms in acromegalic patients. Pituitary 15:466–471
Freda PU, Reyes CM, Nuruzzaman AT, Sundeen RE, Bruce JN (2003) Basal and glucose-suppressed GH levels less than 1 microg/L in newly diagnosed acromegaly. Pituitary 6:175–180
Lim DJ, Kwon HS, Cho JH, Kim SH, Choi YH, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK (2007) Acromegaly associated with type 2 diabetes showing normal IGF-1 levels under poorly controlled glycemia. Endocr J 54:537–541
Minuto FM, Resmini E, Boschetti M, Rebora A, Fazzuoli L, Arvigo M, Giusti M, Ferone D (2012) Biochemical diagnosis and assessment of disease activity in acromegaly: a two-decade experience. Pituitary 15:215–221
Machado EO, Taboada GF, Neto LV, Van Haute FR, Corrêa LL, Balarini GA, Shrank Y, Goulart M, Gadelha MR (2008) Prevalence of discordant GH and IGF-I levels in acromegalics at diagnosis, after surgical treatment and during treatment with octreotide LAR. Growth Horm IGF Res 18:389–393
Halperin I, Casamitjana C, Flores L, Fernandez-Balsells M, Vilardell E (1999) The role of IGF binding protein-3 as a parameter of activity in acromegalic patients. Eur J Endocrinol 141:145–148
Espinosa-de-los-Monteros AL, Mercado M, Sosa E, Lizama O, Guinto G, Lopez-Felix B, Garcia O, Hernandez I, Ovalle A, Mendoza V (2002) Changing patterns of insulin-like growth factor-I and glucose-suppressed growth hormone levels after pituitary surgery in patients with acromegaly. J Neurosurg 97:287–292
Minniti G, Jaffrain-Rea ML, Esposito V, Santoro A, Tamburrano G, Cantore G (2003) Evolving criteria for post-operative biochemical remission of acromegaly: can we achieve a definitive cure? An audit of surgical results on a large series and a review of the literature. Endocr Relat Cancer 10:611–619
Vierhapper H, Heinze G, Gessl A, Exner M, Bieglmayr C (2003) Use of the oral glucose tolerance test to define remission in acromegaly. Metabolism 52:181–185
Espinosa-de-Los-Monteros AL, Sosa E, Cheng S, Ochoa R, Sandoval C, Guinto G, Mendoza V, Hernandez I, Molina M, Mercado M (2006) Biochemical evaluation of disease activity after pituitary surgery in acromegaly: a critical analysis of patients who spontaneously change disease status. Clin Endocrinol 64:245–249
Alexopoulou O, Bex M, Abs R, T’Sjoen G, Velkeniers B, Maiter D (2008) Divergence between growth hormone and insulin-like growthfactor-1 concentrations in the follow-up of acromegaly. J Clin Endocrinol Metab 93:1324–1330
Bianchi A, Giustina A, Cimino V, Pola R, Angelini F, Pontecorvi A, De Marinis L (2009) Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly. J Clin Endocrinol Metab 94:2015–2022
Jane JA, Starke RM, Elzoghby MA, Reames DL, Payne SC, Thorner MO, Marshall JC, Laws ER Jr, Vance ML (2011) Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome. J Clin Endocrinol Metab 96(9):2732–2740
Scally N, Swords F, Gorick S, Chipchase A, Temple R (2012) Discordance between growth hormone and IGF1 in patients with acromegaly following recent guidelines. Endocr Abstracts 28:252
Shin SS, Tormenti MJ, Paluzzi A, Rothfus WE, Chang YF, Zainah H, Fernandez-Miranda JC, Snyderman CH, Challinor SM, Gardner PA (2012) Gardner Endoscopic endonasal approach for growth hormone secreting pituitary adenomas: outcomes in 53 patients using 2010 consensus criteria for remission. Pituitary. doi:10.1007/s11102-012-0440-6
Freda PU (2009) Monitoring of acromegaly: what should be performed when GH and IGF-1 levels are discrepant? Clin Endocrinol 71:166–170
Barkan AL, Halasz I, Dornfeld KJ, Jaffe CA, Friberg RD, Chandler WF, Sandler HM (1997) Pituitary irradiation is ineffective in normalizing plasma insulin-like growth factor I in patients with acromegaly. J Clin Endocrinol Metab 82:3187–3191
Isaksson O, Jansson J, Sjogren K, Ohlsson C (2001) Metabolic functions of liver-derived (endocrine) insulin-like growth factor-I. Horm Res 55(Suppl 1):18–21
Rojdmark S, Brismar K (2001) Decreased IGF-I bioavailability after ethanol abuse in alcoholics: partial resolution after short term abstinence. J Endocrinol Invest 24:476–482
Neggers SJ, Kopchick JJ, Jorgensen JO, van der Lely AJ (2011) Hypothesis: extra-hepatic acromegaly: a new paradigm? Eur J Endocrinol 164:11–16
Blum W, Ranke M, Kietzmann K, Tonshoff B, Mehls O (1991) Growth hormone resistance and inhibition of somatomedin activity by excess insulin-like growth factor binding protein in uraemia. Paediatr Nephrol 5:539–544
Merimee T, Zapf J, Froesch E (1982) Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab 55:999–1002
Leung KC, Johannsson G, Leong GM, Ho KKY (2004) Estrogen regulation of growth hormone action. Endocr Rev 25:693–721
Kamenicky P, Santos CD, Espinosa C, Salenave S, Galland F, Bouc YL, Maison P, Bougnères P, Chanson P (2009) GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly. Eur J Endocrinol 161:231–235
Weissberger AJ, Ho KK, Lazarus L (1991) Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 72:374–381
Faria AC, Bekenstein LW, Booth RA Jr, Vaccaro VA, Asplin CM, Veldhuis JD, Thorner MO, Evans WS (1992) Pulsatile growth hormone release in normal women during the menstrual cycle. Clin Endocrinol 36:591–596
Ovesen P, Vahl N, Fisker S, Veldhuis JD, Christiansen JS, Jorgensen JO (1992) Increased pulsatile, but not basal, growth hormone secretion rates and plasma insulin-like growth factor I levels during the periovulatory interval in normal women. J Clin Endocrinol Metab 83:1662–1667
Birzniece V, Sutanto S, Ho KKY (2012) Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators. J Clin Endocrinol Metab 97:E521–E527
Winer LM, Shaw MA, Baumann G (1990) Basal plasma growth hormone levels in man: new evidence for rhthymicity of growth hormone secretion. J Clin Endocrinol Metab 70:1678–1686
Colao A, Pivonello R, Auriemma RS, Grasso LFS, Galdiero M, Pivonello C, Lombardi G, Savastano S (2011) Growth hormone nadir during oral glucose load depends on waist circumference, gender and age: normative data in 231 healthy subjects. Clin Endocrinol 74:234–240
Bidlingmaier M, Freda PU (2010) Measurement of human growth hormone by immunoassays: current status, unsolved problems and clinical consequences. Growth Horm IGF Res 20(1):19–25
Peacey SR, Toogood AA, Veldhuis JD, Thorner MO, Shalet SM (2001) The relationship between 24-hour growth hormone secretion and insulin-like growth factor I in patients with successfully treated acromegaly: impact of surgery or radiotherapy. J Clin Endocrinol Metab 86(1):259–266
Holdaway IM, Rajasoorya CR, Gamble GP, Stewart AW (2003) Long term treatment outcome in acromegaly. Growth Horm IGF Res 13:185–192
Tanimoto K, Hizuka N, Fukuda I, Takano K, Hanafusa T (2008) The influence of age on the GH–IGF1 axis in patients with acromegaly. Eur J Endocrinol 159:375–379
Marzullo P, Di Somma C, Pratt K, Khosravi J, Diamandis A, Lombardi G, Colao A, Rosenfeld RG (2001) Usefulness of different biochemical markers of the insulin-like growth factor family in diagnosing growth hormone excess and deficiency in adults. J Clin Endocrinol Metab 86(7):3001–3008
Cozzi R, Attanasio R, Montini M, Pagani G, Lasio G, Lodrini S, Barausse M, Albizzi M, Dallabonzana D, Pedroncelli AM (2003) Four-year treatment with octreotide-long-acting repeatable in 110 acromegalic patients: predictive value of short-term results? J Clin Endocrinol Metab 88:3090–3098
Boguszewski CL (2003) Molecular heterogeneity of human growth hormone from basic research to clinical applications. J Endocrinol Invest 26:274–288
Baumann G (1991) Growth hormone heterogeneity: genes, isohormones, variants and binding proteins. Endocr Rev 12:424–429
Milani D, Carmichael JD, Welkowitz J, Ferris S, Reitz RE, Danoff A, Kleinberg DL (2004) Variability and reliability of single serum IGF-I measurements: impact on determining predictability of risk ratios in disease development. J Clin Endocrinol Metab 89(5):2271–2274
Matta M, Bongard V, Grunenwald S, Maiza JC, Bennet A, Caron P (2011) Clinical and metabolic characteristics of acromegalic patients with high IGF1/normal GH levels during somatostatin analog treatment. Eur J Endocrinol 164:885–889
Mercado M, González B, Sandoval C, Esquenazi Y, Mier F, Vargas G, de los Monteros AL, Sosa E (2008) Clinical and biochemical impact of the d3 growth factor receptor genotype in acromegaly. J Clin Endocrinol Metab 93(3):3411–3415
Freda PU (2003) Pitfalls in the biochemical assessment of acromegaly. Pituitary 6:135–140
Parkinson C, Renehan AG, Ryder WD, O’Dwyer ST, Shalet SM, Trainer PJ (2002) Gender and age influence the relationship between serum GH and IGF-Iin patients with acromegaly. Clin Endocrinol 57:363–370
Holly JM, Cotterill AM, Jemmott RC, Shears D, Al-Othman S, Chard T, Wass JA (1991) Inter-relations between growth hormone, insulin, insulin-like growth factor-I (IGF-I), IGF-binding protein-1 (IGFBP-1) and sex hormone-bindingglobulin in acromegaly. Clin Endocrinol 34:275–280
Dekkers OM, Biermasz NR, Pereira AM, Romijn JA, Vandenbroucke JP (2008) Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Metab 93:61–67
Holdaway IM, Bolland MJ, Gamble GD (2008) A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly. Eur J Endocrinol 159:89–95
Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Werger KV, Melmed S (2000) Criteria for cure of acromegaly: a consensus statement. J Clin Endocrinol Metab 85:526–529
Sheppard MC (2005) GH and mortality in acromegaly. J Endocrinol Invest 28(11 Suppl International):75–77
Sughrue ME, Chang EF, Gabriel RA, Aghi MK, Blevins LS (2011) Excess mortality for patients with residual disease following resection of pituitary adenomas. Pituitary 14(3):276–283
Holdaway IM, Rajasoorya RC, Gamble GD (2004) Factors influencing mortality in acromegaly. J Clin Endocrinol Metab 89(2):667–674
Puder JJ, Nilavar S, Post KD, Freda PU (2005) Relationship between disease-related morbidity and biochemical markers of activity in patients with acromegaly. J Clin Endocrinol Metab 90:1972–1978
Ayuk J, Clayton R, Holder G, Sheppard M, Stewart P, Bates A (2004) Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly. J Clin Endocrinol Metab 89(4):1613–1617
Tanimoto K, Hizuka N, Fukuda I, Takano K, Hanafusa T (2008) The influence of age on the GH–IGF1 axis in patients with acromegaly. Eur J Endocrinol 159:375–379
Ronchi CL, Varca V, Giavoli C, Epaminonda P, Beck-Peccoz P, Spada A, Arosio M (2005) Long-term evaluation of postoperative acromegalic patients in remission with previous and newly proposed criteria. J Clin Endocrinol Metab 90:1377–1382
Ronchi CL, Arosio M, Rizzo E, Lania AG, Beck-Peccoz P, Spada A (2007) Adequacy of current postglucose GH nadir limit (1 microg/l) to define long-lasting remission of acromegalic disease. Clin Endocrinol 66:538–542
Freda PU, Nuruzzaman AT, Post KD (2002) Significance of “abnormal” GH suppression after OGTT with normal IGF-I levels in postoperative patients with acromegaly. In: 84th annual meeting of the endocrine society, San Francisco, CA, June 19–22
Biermasz NR, Dekker FW, van Pereira AM, Thiel SW, Schutte PJ, van Dulken H, Romijn JA, Roelfsema F (2004) Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements. J Clin Endocrinol Metab 89:2789–2796
Neggers SJ, van Aken MO, de Herder WW, Feelders RA, Janssen JA, Badia X, Webb SM, van der Lely AJ (2008) Quality of life in acromegalic patients during long-term somatostatinanalog treatment with and without pegvisomant. J Clin Endocrinol Metab 93:3853–3859
Biermasz NR, Pereira AM, Smit JW, Romijn JA, Roelfsema F (2005) Morbidity after long-term remission for acromegaly: persisting joint-related complaints cause reduced quality of life. J Clin Endocrinol Metab 90:2731–2739
Bonapart IE, van Domburg R, ten Have SM, de Herder WW, Erdman RA, Janssen JA, van der Lely AJ (2005) The ‘bio-assay’ quality of life might be a better marker of disease activity in acromegalic patients than serum total IGF-I concentrations. Eur J Endocrinol 152:217–224
Hua SC, Yan YH, Chang TC (2006) Associations of remission status and lanreotide treatment with quality of life in patients with treated acromegaly. Eur J Endocrinol 155:831–837
Rowles SV, Prieto L, Badia X, Shalet SM, Webb SM, Trainer PJ (2005) Quality of life (QOL) in patients with acromegaly is severely impaired: use of a novel measure of QOL: acromegaly quality of life questionnaire. J Clin Endocrinol Metab 90:3337–3341
Melmed S, Cook D, Schopohl J, Goth MI, Lam KSL, Marek J (2010) Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotideAutogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary 13(1):18–28
Clemmons DR (2011) Clinical laboratory indices in the treatment of acromegaly. Clin Chim Acta 412(5–6):403–409
van der Klaauw AA, Pereira AM, van Thiel SW, Frolich M, Iranmanesh A, Veldhuis JD, Roelfsema F, Romijn JA (2007) Attenuatedpulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients. Clin Endocrinol 66:489–498
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The authors wish to thank Dr. Zahid Hussain Khan for editing this manuscript.
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Zeinalizadeh, M., Habibi, Z., Fernandez-Miranda, J.C. et al. Discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly: a stepwise approach and management. Pituitary 18, 48–59 (2015). https://doi.org/10.1007/s11102-014-0556-y
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DOI: https://doi.org/10.1007/s11102-014-0556-y