Literature on hyperprolactinemia in the setting of a nipple piercing is limited to individuals with concomitant breast/chest wall infection. It is unclear if chronic nipple stimulation from a piercing alone can cause sustained elevations of serum prolactin. Nipple piercing is emerging as a more mainstream societal form of body art, and the answer to this clinical question would potentially alter patient management. Our aim was to assess serum prolactin levels in subjects with nipple piercing. Inclusion criteria were as follows: men and women ≥18 years old with nipple piercing(s) present >6 months. Exclusion criteria included: women who are pregnant, lactating or <6 months postpartum; subjects on medications known to increase prolactin levels; chest wall/breast infection at the time of phlebotomy or conditions known to be associated with hyperprolactinemia. Three men and eight women were enrolled. Median (range) ages for men and women were 33 (24–42) and 27 years (23–42), respectively. All except one subject had bilateral piercings. The median interval from nipple piercing to blood draw was 4.0 (2.0–12.0) years. None of the subjects had hyperprolactinemia. Median (range) prolactin levels for men and women were 5.6 ng/mL (3.8–7.4) and 8.0 ng/mL (2.8–10.9), respectively. Our results suggest that in the absence of any concomitant infection, chronic nipple piercing is not associated with hyperprolactinemia.
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Low M, Melmed S, Kleinberg D, Ho K, Robinson A, Verbalis J (2011) Hypothalamus and pituitary. In: Melmed S, Polonsky K, Larsen P, Kronenberg H (eds) Williams textbook of endocrinology, 12th edn. Elsevier Saunders, Philadelphia, pp 103–323
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA, Endocrine Society (2011) Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:273–288
Mayers LB, Chiffriller SH (2008) Body art (body piercing and tattooing) among undergraduate university students: “then and now”. J Adolesc Health 42:201–203
Laumann AE, Derick AJ (2006) Tattoos and body piercings in the United States: a national data set. J Am Acad Dermatol 55:413–421
Demirtas Y, Sariguney Y, Cukurluoglu O, Ayhan S, Celebi C (2004) Nipple piercing: it is wiser to avoid in patients with hyperprolactinemia. Dermatol Surg 30:1184
Modest GA, Fangman JJ (2002) Nipple piercing and hyperprolactinemia. N Engl J Med 347:1626–1627
Tyson JE, Hwang P, Guyda H, Friesen HG (1972) Studies of prolactin secretion in human pregnancy. Am J Obstet Gynecol 113:14–20
Chayen B, Kim YM, Tejani N, Verma UL (1987) Serum prolactin levels during contraction stress test done by the breast pump. Obstet Gynecol 70:884–886
Noel GL, Suh HK, Frantz AG (1974) Prolactin release during nursing and breast stimulation in postpartum and nonpostpartum subjects. J Clin Endocrinol Metab 38:413–423
Jarrell J, Franks S, McInnes R, Gemayel K, Guyda H, Arronet GH, Naftolin F (1980) Breast examination does not elevate serum prolactin. Fertil Steril 33:49–51
Amico JA, Finley BE (1986) Breast stimulation in cycling women, pregnant women and a woman with induced lactation: pattern of release of oxytocin, prolactin and luteinizing hormone. Clin Endocrinol (Oxf) 25:97–106
We are indebted to Robert Kreller (Pathology & Laboratory Medicine Institute, Cleveland Clinic Foundation) for the processing of the prolactin samples and to Christina Reed (Department of Preventative Cardiology, Cleveland Clinic Foundation) for assistance in recruitment for this study.
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Sun, G.E.C., Pantalone, K.M., Gupta, M. et al. Is chronic nipple piercing associated with hyperprolactinemia?. Pituitary 16, 351–353 (2013). https://doi.org/10.1007/s11102-012-0431-7
- Nipple piercing
- Nipple stimulation