Abstract
We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with a pituitary adenoma. A transseptal transsphenoidal tumor mass reduction yielded a histological diagnosis of a collision tumor comprised of a gonadotroph adenoma intermingled with osteochondroma. We discuss a potential causal relationship between the administration of the long-acting gonadotropin-releasing hormone agonist and the sudden appearance of the previously unsuspected sellar lesion. Although the association of these two tumors is very likely coincidental, the possibility of causal relationship is addressed.
This is a preview of subscription content, log in via an institution to check access.
References:
Koutourousiou M, Kontogeorgos G, Wesseling P, Grotenhuis AJ, Seretis A (2009) Collision sellar lesions: experience with eight cases and review of the literature. Pituitary [Epub ahead of print]
Nishio S, Mizuno J, Barrow DL, Takei Y, Tindall GT (1987) Pituitary tumors composed of adenohypophyseal adenoma and Rathke’s cleft cyst elements: a clinicopathological study. Neurosurgery 21:371–377
Noh SJ, Ahn JY, Lee KS, Kim SH (2007) Pituitary adenoma and concomitant Rathke’s cleft cyst. Acta Neurochir (Wien) 149:1223–1228
Kontogeorgos G, Scheithauer BW, Horvath E, Kovacs K, Lloyd RV, Smyth HS et al (1992) Double adenomas of the pituitary: a clinicopathological study of 11 tumors. Neurosurgery 31:840–849
Sano T, Horiguchi H, Xu B, Li C, Hino A, Sakaki M, Kannuki S, Yamada S (1999) Double pituitary adenomas: six surgical cases. Pituitary 1(3–4):243–250
Karavitaki N, Scheithauer BW, Watt J, Ansorge O, Moschopoulos M, Llaguno AV, Wass JA (2008) Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke’s cleft cyst with corticotroph adenoma. Pituitary 11(3):317–323
Güzel A, Er U, Tatli M, Uzunlar AK, Belen D, Bavbek M (2007) Pituitary adenoma coexisting with a suprasellar arachnoid cyst. Turk Neurosurg 17:138–141
Nomikos P, Buchfelder M, Fahlbusch R (1992) Intra- and suprasellar colloid cysts. Pituitary 2:123–126
Kaspera W, Bierzyńska-Macyszyn G, Majchrzak H (1998) A case of parasellar tumor with double histological texture: chromophobe pituitary adenoma and epidermoid cyst. Neurol Neurochir Pol 32:987–996
Koutourousiou M, Seretis A, Kontogeorgos G (2009) Intra-sellar schwannoma co-existing with GH-secreting pituitary adenoma. Acta Neurochir (Wien) [Epub ahead of print]
Rivera J, Alves S, Bianchi CC, Al-Mutawa N, Guiot MC, Zeitouni A (2008) An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. Pituitary [Epub ahead of print]
Banik S, Hasleton PS, Lyon RL (1984) An unusual variant of multiple endocrine neoplasia syndrome: a case report. Histopathology 8(1):135–144
Belza J (1966) Double midline intracranial tumors of vestigial origin: contiguous intrasellar chordoma and suprasellar craniopharyngioma. Case report. J Neurosurg 25(2):199–204
Aoki A, Mori K, Tajima A, Maeda M (1999) Sellar chondroma-case report. Neurol Med Chir (Tokyo) 39(12):870–874
Pospiech J, Mehdorn HM, Reinhardt V, Grote W (1989) Sellar chondroma in a case of Ollier’s disease. Neurochirurgia (Stuttg) 32(1):30–35
de Divitiis E, Spaziante R, Cirillo S, Stella L, Donzelli R (1979) Primary sellar chondromas. Surg Neurol 11(3):229–232
Paillas JE, Alliez B (1974) Intrasellar chondroma-case report. Neurochirurgia (Stuttg) 17(4):136–140
Munemitsu H, Matsuda M, Hirai O, Fukumitsu T, Kawamura J (1981) Intrasellar chondroma. Neurol Med Chir (Tokyo) 21(7):775–780
Brien EW, Mirra JM, Kerr R (1997) Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology I the intramedullary cartilage tumors. Skeletal Radiol 26(6):325–353
Davis A, Goel S, Picolos M, Wang M, Lavis V (2006) Pituitary apoplexy after leuprolide. Pituitary 9(3):263–265
Landolt AM, Rothenbuhler V (1977) Pituitary adenoma calcification. Arch Pathol Lab Med 101(1):22–27
Rennert J, Doerfler A (2007) Imaging of sellar and parasellar lesions. Clin Neurol Neurosurg 109(2):111–124
Zahariadis G, Kontogeorgos G, Liberopoulos K, George S, Kovacs K (1995) Ossifying pituitary gonadotroph adenoma: a case report. Acta Neurochir (Wien) 141(9):1001–1003
Roncaroli F, Fioravanti A, Marliani AF, Calbucci F (1999) Osseous metaplasia in a growth hormone-secreting pituitary adenoma. Clin Neuropathol 18(4):205–207
Kasper S, Friesen HG (1986) Human pituitary tissue secretes a potent growth factor for chondrocyte proliferation. J Clin Endocrinol Metab 62(1):70–76
Ezzat S, Smyth HS, Ramyar L, Asa SL (1995) Heterogenous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas. J Clin Endocrinol Metab 80(3):878–884
Takeda M, Otsuka F, Suzuki J, Kishida M, Ogura T, Tamiya T, Makino H (2003) Involvement of activin/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas. Biochem Biophys Res Commun 306(4):812–818
Yoshikawa H, Nakase T, Myoui A, Ueda T (2004) Bone morphogenetic proteins in bone tumors. J Orthop Sci 9(3):334–340
Disclosure statement
The authors have no conflict of interest
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sahli, R., Christ, E., Kuhlen, D. et al. Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis. Pituitary 14, 405–408 (2011). https://doi.org/10.1007/s11102-009-0199-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11102-009-0199-6