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Hematologic neoplasias and acromegaly

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Abstract

We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as having Waldenstrom’s macroglobulinemia (WM). Acromegaly is an uncommon disease and epidemiological studies have provided increasingly debated evidence that elevated IGF-I levels might enhance the neoplastic risk, and that cancers constitute the third leading cause of mortality in acromegaly. It is known that GH and IGF-I can activate B cell lymphocytes, and that IGF-I receptor is universally expressed in MM cells. Although the complication of acromegaly with WM or MM in patients has rarely been reported until now, we described two case reports of acromegalic patients with those hematological neoplasias, which allow a discussion about this controversial issue.

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Acknowledgment

The authors thank Dr. Fabiano Serfaty for his interest in helping in the text formatting.

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Authors and Affiliations

  1. Division of Endocrinology, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rua Nascimento Silva, 555/101, Ipanema, Rio de Janeiro, 22421-020, Brazil

    Flavia Regina P. Barbosa, Leonardo Vieira Neto, Giovanna Aparecida B. Lima, Luiz Eduardo Wildemberg & Monica R. Gadelha

  2. Division of Hematology, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Rodrigo Portugal

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  1. Flavia Regina P. Barbosa
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  2. Leonardo Vieira Neto
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  5. Rodrigo Portugal
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  6. Monica R. Gadelha
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Correspondence to Flavia Regina P. Barbosa or Monica R. Gadelha.

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Barbosa, F.R.P., Vieira Neto, L., Lima, G.A.B. et al. Hematologic neoplasias and acromegaly. Pituitary 14, 377–381 (2011). https://doi.org/10.1007/s11102-009-0176-0

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