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Hypogonadotropic hypogonadism: a consequence of Chiari-I malformation

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Abstract

Chronic hydrocephalus, most commonly the result of aqueduct stenosis, is associated with both primary and secondary amenorrhea. Only six cases of secondary amenorrhea have been reported to date. We describe a women with cystic fibrosis who presented with secondary amenorrhea as a consequence of Chiari-I malformation and resultant hydrocephalus. The biochemical picture was characterized by hypogonadotropic hypogonadism. Resolution of the amenorrhea was observed to occur following 3rd ventriculostomy.

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References

  1. Villani R, Tomei G, Gaini SM, Grimoldi N, Spagnoli D, Bello L (1995) Long-term outcome in aqueductal stenosis. Childs Nerv Syst 11:180–185. doi:10.1007/BF00570262

    Article  CAS  PubMed  Google Scholar 

  2. Lowry DW, Lowry DL, Berga SL, Adelson PD, Roberts MM (1996) Secondary amenorrhea due to hydrocephalus treated with endoscopic ventriculocisternostomy. Case report. J Neurosurg 85:1148–1152

    Article  CAS  PubMed  Google Scholar 

  3. Touraine P, Plu-Bureau G, Beressi N, Decq P, Thalabard JC, Kuttenn F (2001) Resumption of luteinizing hormone pulsatility and hypogonadotropic hypogonadism after endoscopic ventriculo-cisternostomy in a hydrocephalic patient. Fertil Steril 76:390–393. doi:10.1016/S0015-0282(01)01877-5

    Article  CAS  PubMed  Google Scholar 

  4. Lee JK, Kim JH, Kim JS, Kim TS, Jung S, Kim SH et al (2001) Secondary amenorrhea caused by hydrocephalus due to aqueductal stenosis: report of two cases. J Korean Med Sci 16:532–536

    CAS  PubMed  Google Scholar 

  5. Rakheja D, Xu Y, Burns DK, Veltkamp DL, Margraf LR (2003) Cystic fibrosis and Chiari type I malformation: autopsy study of two infants with a rare association. Pediatr Dev Pathol 6:88–93. doi:10.1007/s10024-002-0021-1

    Article  PubMed  Google Scholar 

  6. Needleman JP, Panitch HB, Bierbrauer KS, Schidlow DV (2000) Chiari type I malformation in children and adolescents with cystic fibrosis. Pediatr Pulmonol 30:490–492. doi:10.1002/1099-0496(200012)30:6<490::AID-PPUL9>3.0.CO;2-I

    Article  CAS  PubMed  Google Scholar 

  7. Hochhaus F, Butenandt O, Schwarz HP, Ring-Mrozik E (1997) Auxological and endocrinological evaluation of children with hydrocephalus and/or meningomyelocele. Eur J Pediatr 156:597–601. doi:10.1007/s004310050672

    Article  CAS  PubMed  Google Scholar 

  8. Lopponen T, Saukkonen AL, Serlo W, Tapanainen P, Ruokonen A, Lanning P et al (1998) Pituitary function in children with hydrocephalus before and after the first shunting operation. Eur J Endocrinol 138:170–175. doi:10.1530/eje.0.1380170

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, D Floor, Brotherton Wing, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK

    Sampath Satish Kumar & Robert D. Murray

  2. Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK

    Paul Chumas

  3. Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK

    Daniel Peckham

  4. Department of Diagnostic Imaging, Leeds Teaching Hospitals NHS Trust, Leeds, UK

    Ashley Guthrie

Authors
  1. Sampath Satish Kumar
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  2. Paul Chumas
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  3. Daniel Peckham
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  4. Ashley Guthrie
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  5. Robert D. Murray
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Correspondence to Robert D. Murray.

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Kumar, S.S., Chumas, P., Peckham, D. et al. Hypogonadotropic hypogonadism: a consequence of Chiari-I malformation. Pituitary 13, 183–185 (2010). https://doi.org/10.1007/s11102-008-0142-2

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  • DOI: https://doi.org/10.1007/s11102-008-0142-2

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