, Volume 8, Issue 1, pp 3–6 | Cite as

The Epidemiology of Prolactinomas

  • Antonio Ciccarelli
  • Adrian F. Daly
  • Albert BeckersEmail author


Prolactin-secreting tumors (prolactinomas), the most frequently occurring pituitary tumor, have a frequency that varies with age and sex. They occur most frequently in females aged 20 to 50 years old, at which time the female-to-male ratio is approximately 10:1. In the pediatric-adolescent age group, prolactinomas have a prevalence of 100/million population, and account for less than 2% of all intracranial tumors. Prolactinomas occur in approximately 30% of patients with multiple endocrine neoplasia type 1 and in this setting, they may be more aggressive than their sporadic counterparts. Patients with Carney complex or McCune-Albright syndrome may exhibit hyperprolactinemia due to a pituitary tumor derived from somatomammotropic cells that secrete both growth hormone and prolactin. Few familial cases of prolactinoma unrelated to MEN-1 are reported in literature.

Key Words

prolactin prolactinoma pituitary tumor inherited neoplasm epidemiology 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Antonio Ciccarelli
    • 1
  • Adrian F. Daly
    • 1
  • Albert Beckers
    • 1
    • 2
    Email author
  1. 1.Department of Endocrinology, C.H.U. de LiègeUniversity of LiègeBelgium
  2. 2.Department of Endocrinology, C.H.U. de LiègeUniversity of LiègeLiègeBelgium

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