Abstract
Liver disease is a significant global health concern, leading to around two million fatalities annually. This disorder encompasses a broad range of causes, including both well-established factors such as lifestyle choices, as well as less understood origins such as pre-existing medical diseases. In the present scenario, liver cancer poses a significant worldwide health concern, with projections indicating that the number of cases is expected to exceed one million by the year 2025. According to the World Health Organization, numerous developing nations, such as India, continue to rely on the utilization of plants and plant-derived substances for the treatment of diverse ailments. Desmodium Desv., a genus within the Fabaceae family, encompasses about 350 species that are primarily found in tropical and subtropical regions worldwide. These plants have a long-standing history of traditional medicinal use in India, Thailand, and China, particularly for the treatment of liver diseases. The objective of this review is to provide a comprehensive overview of the ethnobotanical applications, phytoconstituents, and hepatoprotective properties associated with all species of Desmodium. The research employed various methodologies. Data on the Desmodium genus was collected up until the year 2022 through the examination of research articles, patents, and diverse online bibliographic databases such as PubMed, Research Gate, PubChem, Science Direct, Scopus, Wiley Online Library, Web of Science, eOL, POWO, and IUCN. The online search was conducted using the following keywords: Desmodium species, review articles, ethnobotanical uses, phytochemical constituents, and hepatoprotective property. In conclusion, it can be inferred that Ethnobotanical research has revealed that these particular species possess diverse pharmacological attributes, including anti-oxidant, anti-inflammatory, anti-bacterial, cytotoxic, and hepatoprotective activities. The analysis of phytochemistry reveals the presence of various compounds such as flavonoids, alkaloids, terpenoids, steroids, phenols, and other constituents inside these species. Out of a total of 350 species, it has been observed that 18 possess hepatoprotective properties. In order to substantiate the hepatoprotective applications and advance the development of prominent pharmaceuticals, additional pharmacological investigations including animal models and phytochemical explorations are necessary.
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References
Adianti M, Aoki C, Komoto M, Deng L, Shoji I, Wahyuni TS, Lusida MI, Soetjipto FH, Kawahara N, Hotta H (2014) Anti-hepatitis C virus compounds obtained from Glycyrrhizauralensis and other Glycyrrhiza species. Microbiol Immunol 58:180–187
Amin ZA, Bilgen M, Alshawsh MA, Ali HM, Hadi AHA, Abdulla MA (2012) Protective role of Phyllanthusniruri extract against thioacetamide-induced liver cirrhosis in rat model. Evid Based Complement Altern Med. https://doi.org/10.1155/2012/241583
Anandasadagopan SK, Sundaramoorthy C, Pandurangan AK, Nagarajan V, Srinivasan K, Ganapasam S (2017) S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats. Hum Exp Toxicol 36(11):1186–1200
Asrani SK, Devarbhavi H, Eaton J, Kamath PS (2019) Burden of liver diseases in the world. J Hepatol 70(1):151–171
Bandekar S, Joshi AB, Bhandarkar AV, Gurav S, Jeedigunta MK (2021) Isolation, characterization and cytotoxic potential of Desmodiumoojeinensis (Roxb) H. Ohashi: a threatened medicinal plant. J Appl Pharm Sci 11(2):102–105
Bedi O, Bijjem KRV, Kumar P, Gauttam V (2016) Herbal induced hepatoprotection and hepatotoxicity: a critical review. Indian J Physiol Pharmacol 60(1):6–21
Beier JI, Arteel GE (2021) Environmental exposure as a risk-modifying factor in liver diseases: knowns and unknowns. Acta Pharm Sinica B 11(12):3768–3778
Bhosle V (2013) Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodiumtriflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion. RevistaBrasileira De Farmacognosia 23(4):692–698
Burits M, Bucar F (2000) Antioxidant activity of Nigella sativa essential oil. Phytother Res 14(5):323–328
Charles MC, Oleba OE, Obeten KE, Obono ES (2016) Antinociceptive properties of desmodium adscendens in mice. Saudi J Med Pharm Sci 2:79–85
Chen YF, Tsai HY, Wu TS (1995) Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med 61:2–8
Editorial Committee of ZhonghuaBencao National Traditional Chinese Herb Administration (1996) ZhonghuaBencao (Chinese Herbal Medicine). Shanghai Science and Technology Publishing House, Shanghai, pp 3120–3343
Della Loggia R, Tubaro A, Dri P, Zilli C, Del Negro P (1986) The role of flavonoids in the anti-inflammatory activity of Chamomillarecutita. Prog Clin Biol Res 213:481–484
Devi N, Gupta AK, Prajapati SK (2019) Prospects of traditionally important Apocynaceae plants of India in cancer remediation. J Drug Deliv Ther 9(1):293–302
Dhar D, Baglieri J, Kisseleva T, Brenner DA (2020) Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med 245(2):96–108
Editorial Committee of Fujian Institute of Chinese Medicine (1994) Fujian MateriaMedica. Fujian Science and Technology Press, Fuzhou, pp. (vol. II) 519, 520, (vol. I) 205, 312, 326, 327, 328, 332.
Editorial Committee of Guizhou Institute of ChineseMedicine (1970) Medicinal herbs of Guizhou. Guizhou People’s Press, Guiyang, pp. (vol. I) 91, 93, 823, (vol. II) 836, 887.
European Association for the Study of the Liver (2018) EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 69(1):182–236
Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Satpathy M (2017) Global regional and national cancer incidence mortality years of life lost years lived with disability and disability-adjusted life-years for 32 cancer groups 1990–2015: a systematic analysis for the global burden of disease study. JAMA Oncol 3(4):524–548
Fu Y, Zu Y, Liu W, Hou C, Chen L, Li S, Shi X, Tong M (2007) Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins. J Chromatogr A 1139:206–213
Gan N, LI TH, Yang X, HE P (2018) Constituents in Desmodium blandum and their antitumor activity. Chin Traditi Herb Drug 40(6):852–856
Gan WS (1967) Tanwang Medicinal Flora. Taibei: Natl Res Inst Chin Med
Ghosh D, Anandakumar A (1983) Anti-inflammatory and analgesic activities of gangetin—a pterocarpanoid from Desmodium gangeticum. Indian J Pharmacol 15:391–402
Gomes A, Couto D, Alves A, Dias I, Freitas M, Porto G, Fernandes E (2012) Trihydroxyflavones with antioxidant and anti-inflammatory efficacy. BioFactors 38(5):378–386
Govindarajan R, Rastogi S, Vijayakumar M, Shirwaikar A, Rawat AKS, Mehrotra S, Pushpangadan P (2003) Studies on the antioxidant activities of Desmodium gangeticum. Biol Pharm Bull 26:1424–1427
Govindarajan R, Vijayakumar M, Shirwaikar A, Rawat AKS, Mehrotra S, Pushpangadan P (2006) Antioxidant activity of Desmodium gangeticum and its phenolics in arthritic rats. Acta Pharm 56:489–496
Govindarajan R, Vijayakumar M, Rao ChV, Shirwaikar A, Kumar S, Rawat AKS, Pushpangadan P (2007) Antiinflammatory and antioxidant activities of Desmodium gangeticum fractions in carrageenan-induced inflamed rats. Phytother Res 21:975–979
Gu LZ, Zhang BS, Nan JH (1988) Anti-inflammatory effects of two species of Lysimachia christinae Hance and Desmodium styracifolium (Osbeck) Merr. Zhong Yao Tong Bao (beijing, China: 1981) 13(7):40–63
Ha LM, Luyen NT, Phuong NT, Huyen DTT, Huong LM, Quan PM, Dat NT (2018) Isoflavonoids from Desmodium heterophyllum aerial parts. Nat Product Commun 13(6):1934578X1801300612
Hassan MM, Khan SA, Shaikat AH, Hossain E, Hoque A, Ullah H, Islam S (2013) Analgesic and anti-inflammatory effects of ethanol extracted leaves of selected medicinal plants in animal model. Vet World 6(2):68
He L, He T, Farrar S, Ji L, Liu T, Ma X (2017) Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 44(2):532–553
Hong M, Li S, Tan HY, Wang N, Tsao SW, Feng Y (2015) Current status of herbal medicines in chronic liver disease therapy: the biological effects, molecular targets and future prospects. Int J Mol Sci 16(12):28705–28745
Hsu WH, Liao SC, Chyan YJ, Huang KW, Hsu SL, Chen YC, Huang CYF (2019) Graptopetalum paraguayense inhibits liver fibrosis by blocking TGF-β signaling in vivo and in vitro. Int J Mol Sci 20(10):2592
Ilandara R, Chandrapala R, Jayasuriya WBN, Suresh TS (2015) Phytochemical and ethno-pharmacological properties of Desmodiumtriflorum; a review
Indu MS, Narayanankutty A, Ramavarma SK, Manalil JJ, Padikkala J, Raghavamenon AC (2021) Desmodiumgyrans DC. modulates lipid trafficking in cultured macrophages and improves functional high-density lipoprotein in male wistar rats. Indian J Pharmacol 53(4):286
IUCN, Conservation international, and natureserve (2006) Globalamphibian assessment. IUCN, Washington, D.C. Available from www.globalamphibians.org. Accessed August 2008
Jabbar S, Khan MT, Choudhuri MS, Sil BK (2004) Bioactivity studies of the individual ingredients of the Dashamularishta. Pak J Pharm Sci 17:9–17
Jayadevaiah KV, Bhat I, Joshi AB, Vijaykumar MMJ, Rawal P (2012) Hepatoprotective activity of Desmodiumoojeinense (Roxb) H Ohashi against paracetamol induced hepatotoxicity. Asian J Pharm Health Sci 2(2).
Jayaram U, Srivastava N (2016) Ethnopharmacological and Phytochemical profile of three potent Desmodium species: Desmodiumgangeticum (L.) DC, Desmodiumtriflorum Linn. and Desmodiumtriquetrum Linn. J Chem Pharm Res 8(7):91–97
Joshi H, Parle M (2007) Pharmacological evidences for the antiamnesic effects of Desmodiumgangeticum in mice. Iran J Pharm Res 6:199–207
Jung S, Shin J, Oh J, Enkhtaivan G, Lee SW, Gopal J, Oh JW (2019) Cytotoxic and apoptotic potential of Phyllodiumelegans extracts on human cancer cell lines. Bioengineered 10(1):501–512
Karim R, Begum MM, Jui Y, Islam T, Billah M, Arafat Y, Rahman M (2021) In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminaliacitrina (Roxb.) fruits. Clini Phytosci 7(1):1–10
Kaweetripob W, Thongnest S, Boonsombat J, Kheawchaum S, Mahidol C, Prawat H, Ruchirawat S (2022) Cytotoxic isoflavonoids from the roots of Desmodiumvelutinum (Willd.) DC. Phytochem Lett 48:47–53
Khan S, Rahman MM, Kabir F, Nahar K, Mamun F, Lasker S, Haque MA (2020) Trichosanthesdioica Roxb. prevents hepatic inflammation and fibrosis in CCl4-induced ovariectomized rats. Clini Nutr Exp 33:1–17
Khoury T, Rmeileh AA, Yosha L, Benson AA, Daher S, Mizrahi M (2015) Drug induced liver injury: review with a focus on genetic factors, tissue diagnosis, and treatment options. J Clin Transl Hepatol 3(2):99
Kim E, Yoon KD, Lee WS, Yang WS, Kim SH, Sung NY, Cho JY (2014) Syk/Src-targeted anti-inflammatory activity of Codariocalyx motoriusethanolic extract. J Ethnopharmacol 155(1):185–193
Kirtikara KR, Basu BD, An ICS, Blatter E, Caius JF, Mhaskar KS (2001) Indian medicinal plants, with illustrations
Kumar V, Kalita J, Misra UK, Bora HK (2015) A study of dose response and organ susceptibility of copper toxicity in a rat model. J Trace Elem Med Biol 29:269–274
Kurian GA, Yagnesh N, Kishan RS, Paddikkala J (2008) Methanol extract of Desmodium gangeticum roots preserves mitochondrial respiratory enzymes, protecting rat heart against oxidative stress induced by reperfusion injury. J Pharm Pharmacol 60:523–530
Kurian GA, Rajamani T, Ramanarayanan P, Paddikkala J (2009) A comparative study on in vitro and in vivo antioxidant activities of aqueous extract of Desmodium gangeticum (Leguminosae) root. Int J Green Pharm 3:324–331
Lai SC, Peng WH, Huang SC, Ho YL, Huang TH, Lai ZR, Chang YS (2009) Analgesic and anti-inflammatory activities of methanol extract from Desmodium triflorum DC in mice. Am J Chin Med 37(03):573–588
Lai SC, Ho YL, Huang SC, Huang TH, Lai ZR, Wu CR, Lian KY, Chang YS (2010) Antioxidant and antiproliferative activities of Desmodium triflorum (L.) DC. Am J Chin Med 38:329–342
Lau ST, Lin ZX, Zhao M, Leung PS (2008) Bruceajavanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines. Phytother Res Int J Devot Pharmacol Toxicol Eval Nat Prod Deriv 22(4):477–486
Li SC, Ho YL, Huang SC, Huang TH, Lai ZR, Wu CR, Lian KY, Chang YS (2010) Antioxidant and antiproliferative activities of Desmodium triflorum (L.) DC. Am J Chin Med 38:329–342
Li W, Sun YN, Yan XT, Yang SY, Kim S, Chae D, Kim YH (2014) Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems. Arch Pharm Res 37:721–727
Li GF, Fu L, Hong T (2008) Higher plants of China
Libman A, Bouamanivong S, Southavong B, Sydara K, Soejarto DD (2006) Medicinal plants: an important asset to health care in a region of Central Laos. J Ethnopharmacol 106:303–311
Liguo Fu, Chen T, Lang K, Hong T, Lin Qi (2008) Higher plants of China. Qingdao Publishing House, Qingdao, p 152
Llovet JM, Castet F, Heikenwalder M, Maini MK, Mazzaferro V, Pinato DJ, Finn RS (2022) Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol 19(3):151–172
Ma KJ, Zhu ZZ, Yu CH, Zhang H, Liu J, Qin LP (2011a) Analgesic, anti-inflammatory, and antipyretic activities of the ethanol extract from Desmodiumcaudatum. Pharm Biol 49(4):403–407
Ma X, Zheng C, Hu C, Rahman K, Qin L (2011b) The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry and pharmacology. J Ethnopharmacol 138(2):314–332
Maes F, Pieters L, Vlietinck A, Apers S, Hermans N (2020) European Patent Specification, Date of filing: 20.03.2013
Magielse J, Arcoraci T, Breynaert A, van Dooren I, Kanyanga C, Fransen E, Hermans N (2013) Antihepatotoxic activity of a quantified Desmodiumadscendens decoction and D-pinitol against chemically-induced liver damage in rats. J Ethnopharmacol 146(1):250–256
Maheshwari JK (2019) Ethnobotany and medicinal plants of Indian subcontinent. Scientific Publishers, Amsterdam
Mao S, Li Z, Li C (2007) Studies on antioxidation activity ofthree plants of Desmodium. J Yun Nan Univ Nat Sci 29:393
Melaram R (2021) Environmental risk factors implicated in liver disease: a mini-review. Front Public Health 9:738
Ming Z, Shengmin Y, Linyun H (2001) The effect of total Desmodiumpulchellum alkaloids on the relevant markers of experimental hepatic fibrosis animals. Chin Hepatol 6:168–170
Mohan PK, Moola AK, Kumar TS, Kumari BD (2020) A comprehensive review of the phytochemical and pharmacological properties of Desmodium gangeticum (L.) DC. J Adv Sci Res 11:90–97
Muanda FN, Bouayed J, Djilani A, Yao C, Soulimani R, Dicko A (2011) Chemical composition and cellular evaluation of the antioxidant activity of Desmodiumadscendens leaves. Evid Based Complement Altern Med 2011:9
Nasreen S, Safeer S, Dar KK, Andleeb S, Ejaz M, Khan MA, Ali S (2018) Etiology of hepatocellular carcinoma and treatment through medicinal plants: a comprehensive review. Orient Pharm Exp Med 18:187–197
Navarro VJ, Senior JR (2006) Drug-related hepatotoxicity. N Engl J Med 354(7):731–739
Nawab A, Yunus M, Mahdi AA, Gupta S (2011) Evaluation of anticancer properties of medicinal plants from the Indian sub-continent. Mol Cell Pharmacol 3(1):21–29
Ning G, Tianhua L, Xin Y, He P (2009) Constituents in Desmodiumblandum and their antitumor activity. Trad Her Drug 40:852–856
Niranjan A, Tewari SK (2008) Phytochemical composition and antioxidant potential of Desmodiumgangeticum (Linn.) DC. Nat Product Radiance 7:35–43
Pandey MM, Rastogi S, Rawat AKS (2013) Indian traditional ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Altern Med. https://doi.org/10.1155/2013/376327
Perera HDSM, Samarasekera JKRR, Handunnetti SM, Weerasena OVDSJ, Weeratunga HD, Jabeen A, Choudhary MI (2018) In vitro pro-inflammatory enzyme inhibition and anti-oxidant potential of selected Sri Lankan medicinal plants. BMC Complement Altern Med 18(1):1–15
Phan MG, Phan TS, Matsunami K, Otsuka H (2010) Flavonoid compounds from Desmodium styracifolium of Vietnamese origin. Chem Nat Comp 46(5):797–798
POWO (2022) Plants of the world online. Royal botanic gardens, kew; Accessed 17 June 2022. https://powo.science.kew.org/
Prasad MVV, Balakrishna K, Carey MW (2005) Hepatoprotective activity of roots of Desmodium gangeticum (Linn.) DC. Asian J Chem 17:2847–2849
Raghavan RS, Wadhwa BM, Ansari MY, Rao RS (1981) Checklist of the plants of Gujarat. Records-Botanical Survey of India
Rashid MMU, Kabir H, Sayeed MA, Alam R, Kabir MF (2013) Sedative and cytotoxic properties of the leaf extract of Desmodium paniculatum. J Pharmacogn Phytochem 2:63–67
Rastogi S, Pandey MM, Rawat AKS (2011) An ethnomedicinal phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC. J Ethnopharmacol 136(2):283–296
Rathi A, Rao CV, Ravishankar B, De S, Mehrotra S (2004) Anti-inflammatory and anti-nociceptive activity of the water decoction Desmodium gangeticum. J Ethnopharmacol 95:259–263
Sayiner M, Golabi P, Younossi ZM (2019) Disease burden of hepatocellular carcinoma: a global perspective. Dig Dis Sci 64:910–917
Sen S, Chakraborty R (2015) Toward the integration and advancement of herbal medicine: a focus on traditional Indian medicine. Botanics Targets Therapy 5:33–44
Sepanlou SG, Safiri S, Bisignano C, Ikuta KS, Merat S, Saberifiroozi M, Padubidri JR (2020) The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol 5(3):245–266
Shah U, Shah R, Acharya S, Acharya N (2013) Novel anticancer agents from plant sources. Chin J Nat Med 11:16–23. https://doi.org/10.1016/s1875-5364(13)60002-3
Shah GL (1987) Flora of Gujarat state. Sardar Patel University 1:204–211
Sharma A, Nagalli S (2021) Chronic liver disease. In: StatPearls [Internet]. StatPearls Publishing.
Shivakumar K, Murali S, Kumar GV (2021) Investigation of hepatoprotective activity of Desmodium gangeticum Leaf extract against paracetamol induced-liver damage in rats. Int J Res Publ Rev 2(11):343–351
Singh A, Duggal S, Suttee A (2009) Acanthus ilicifolius Linn.-lesser known medicinal plants with significant pharmacological activities. Int J Phytomed 1(1):1–3
Skoutakis VA, Carter CA, Mickle TR, Smith VH, Arkin CR, Altssandratos J, Pretty DE (1988) Review of diclofenac and evaluation of its place in therapy as a non-steroidal antiinflammatory agent. Drug Intell Clin Pharm 22:850–859
Tabuti JRS, Lye KA, Dhillion SS (2003) Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. J Ethnopharmacol 88:19–44
Talari M, Seydi E, Salimi A, Mohsenifar Z, Kamalinejad M, Pourahmad J (2014) Dracocephalum: novel anticancer plant acting on liver cancer cell mitochondria. BioMed Res Int. https://doi.org/10.1155/2014/892170
Tran TD, Bui TQ, Le TA, Nguyen MT, Hai NTT, Pham NH, Nhung NTA (2021) Styracifoline from the vietnamese plant Desmodium styracifolium: a potential inhibitor of diabetes-related and thrombosis-based proteins. ACS Omega 6(36):23211–23221
Trout K (1997) Trout’s notes on the genus Desmodium. Better Days Publishing, pp 1–38
Tsafack BT, Ponou BK, Teponno RB, Nono RN, Jenett-Siems K, Melzig MF, Tapondjou LA (2017) Integracide K: a new tetracyclic triterpenoid from Desmodium uncinatum (Jacq.) DC. (Fabaceae). Nat Product Sci 23(2):113–118
Tsafack BT, Bomgning CL, Kühlborn J, Fouedjou RT, Ponou BK, Teponno RB, Tapondjou LA (2018) Protective effects of extracts, isolated compounds from Desmodium uncinatum and semi-synthetic isovitexin derivatives against lipid peroxidation of hepatocyte’s membranes. Adv Biol Chem 8(06):101
Tsai JC, Huang GJ, Chiu TH, Huang SS, Huang SC, Huang TH et al (2011) Antioxidant activities of phenolic components from various plants of Desmodium species. Afr J Pharm Pharmacol 5(4):468–476
Tubéry P, Tubéry AM (1989) Use of Desmodium in the treatment of hepatitis, and medicaments thereof. Patent EP0309342 (A1).
Wahyuni TS, Utsubo CA, Hotta H (2016) Promising anti-hepatitis C virus compounds from natural resources. Nat Prod Commun 11(8):1934578X1601100840
Wang F, Yang L, Liu M, Lu M, Cheng Y, Jia H (1997) A primary study on antagonizing effects of anti-snake venom Chinese herbs on endothelin-1 and sarafotoxin 6b. ZhongGuoZhong Yao ZaZhi 22:620–622
White R (2005) International legume database and information service. ILDIS, UK. Desmodium (Beggarlice, Beggars Lice, Hitch Hikers, Tick’s Clover, Tick-trefoil) North Carolina Extension Gardener Plant Toolbox.
Yadav AK, Agrawal J, Pal A, Gupta MM (2013) Novel anti-inflammatory phytoconstituents from Desmodium gangeticum. Nat Prod Res 27(18):1639–1645
Zhu ZZ, Ma KJ, Ran X, Zhang H, Zheng CJ, Han T, Qin LP (2011) Analgesic, anti-inflammatory and antipyretic activities of the petroleum ether fraction from the ethanol extract of Desmodium podocarpum. J Ethnopharmacol 133(3):1126–1131
Zielińska-Pisklak MA, Kaliszewska D, Stolarczyk M, Kiss AK (2015) Activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant Desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy. J Pharm Biomed Anal 102:54–63
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The authors duly acknowledge funding agencies DST-PURSE, India for providing all the instrumentation facilities for carrying out the research work in the Dept. of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
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ARG: Conceptualization ideas, methodology, formal analysis, data curation, methodology, framing out the draft, Writing—original review draft and editing; AJ, AB: Conceptualization, formal analysis. SS, KT: Software, data analysis. MP: framing out the draft, validation; GN: conceptualization, formal analysis, supervision, project administration, validation.
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George, A.R., Jeganathan, A., Byju, A. et al. A comprehensive review of the Desmodium genus: An innovative exploration of its phytopharmacological characteristics, hepatoprotective capabilities, underlying mechanisms of action and possible applications. Phytochem Rev (2024). https://doi.org/10.1007/s11101-024-09963-7
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DOI: https://doi.org/10.1007/s11101-024-09963-7