Abstract
Aromatic grasses of Cymbopogon (Poaceae) are a known genus of medicinal plants used in traditional medicine by the native people of America, Asia, and Africa. Due to large amounts of valuable essential oils they are readily used in many branches of industry. The potential therapeutic effects of Cymbopogon essential oils as well as the potential therapeutic effects of their active substances (such as citronellal, citronellol, geraniol, and eugenol) have been widely studied. Their neurobehavioral properties, including antinociceptive-, antidepressant-, antistress-, anxiolytic-, anticonvulsant-, and hypnotic/sedative-like activity are of particular interest. As civilization grows, the prevalence of neural and mental disorders increases and as a consequence, the demand for new drugs with aforementioned properties increases as well. In the light of the above, the plants from Cymbopogon genus are suggested by many scientists as a perfect candidate for further pharmaceutical research. The aim of current study is to critically review the available data in order to evaluate the pharmacological relevance of essential oils from Cymbopogon genus.
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References
Adeneye AA, Agbaje EO (2007) Hypoglycemic and hypolipidemic effects of fresh leaf aqueous extract of Cymbopogon citratus Stapf. in rats. J Ethnopharmacol 112:440–444
Akhila A (2010) Essential oil-bearing grasses: the genus Cymbopogon. CRC Press, Boca Raton
Arome D, Enegide C, Ameh SF (2014) Pharmacological evaluation of anxiolytic property of aqueous root extract of Cymbopogon citratus in mice. Chron. Young Sci 5:33–38
Bachiega TF, Sforcin JM (2011) Lemongrass and citral effect on cytokines production by murine macrophages. J Ethnopharmacol 137:909–913
Baser KHC, Buchbauer G (2015) Handbook of essential oils: science, technology, and applications. CRC Press, New York
Bertea CM, Maffei MF (2010) The genus Cymbopogon: botany, including anatomy, physiology, biochemistry and molecular biology in Akhila A essential oil-bearing grasses: the genus Cymbopogon. CRC Press, Boca Raton, pp 1–24
Blanco MM, Costa CA, Freire AO et al (2009) Neurobehavioral effect of essential oil of Cymbopogon citratus in mice. Phytomedicine 16:265–270
Boukhatem MN, Ferhat MA, Kameli A et al (2014) Lemon grass (Cymbopogon citratus) essential oil as a potent antiinflammatory and antifungal drugs. Libyan J Med 9:25431
Brito RG, Guimaraes AG, Quintans JS et al (2012) Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents. J Nat Med 66:637–644
Cerceau CI, Barbosa LCA, Alvarenga ES et al (2020) 1 H-NMR and GC for detection of adulteration in commercial essential oils of Cymbopogon ssp. Phytochem Anal 31(1):88–97
Chisowa EH, Hall DR, Farman DI (1998) Volatile constituents of the essential oil of Cymbopogon citratus Stapf grown in Zambia. Flavour Fragr J 131:29–30
Costa CA, Bidinotto LT, Takahira RK et al (2011a) Cholesterol reduction and lack of genotoxic or toxic effects in mice after repeated 21-day oral intake of lemongrass (Cymbopogon citratus) essential oil. Food Chem Toxicol 49(a):2268–2272
Costa CA, Kohn DO, de Lima VM et al (2011b) The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass). J Ethnopharmacol 137(b):828–836
Costa G, Ferreira JP, Vitorino C et al (2016) Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents. J Ethnopharmacol 178:222–228
de Mello V, Prata MC, da Silva MR et al (2014) Acaricidal properties of the formulations based on essential oils from Cymbopogon winterianus and Syzygium aromaticum plants. Parasitol Res 113:4431–4437
de Santana MT, de Oliveira MG, Santana MF et al (2013) Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice. Pharm Biol 51:1144–1149
de Sousa DP, Goncalves JC, Quintans-Junior L et al (2006) Study of anticonvulsant effect of citronellol, a monoterpene alcohol, in rodents. Neurosci Lett 401:231–235
Delgado IF, Carvalho RR, Nogueira AC et al (1993) Study on embryo-foetotoxicity of beta-myrcene in the rat. Food ChemToxicol 31:31–35
Deng XY, Xue JS, Li HY et al (2015) Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model. Physiol Behav 152:264–271
Ekpenyong CE (2016) Transient hyperbilirubinaemia and sustained elevation of alkaline phosphatase after the ingestion of lemongrass tea. Elixir Physio and Anatomy 100:43512–43516
Fandohan P, Gnonlonfin B, Laleye A et al (2008) Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats. Food ChemToxicol 46:2493–2497
Figueirinha A, Cruz MT, Francisco V et al (2010) Anti-inflammatory activity of Cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: contribution of the polyphenols. J Med Food 13:681–690
Flaishon R, Weinbroum AA, Veenman L et al (2003) Flumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam. Anesth Analg 97:1046–1052
Ganjewala D (2009) Cymbopogon essential oil composition and bio-actives. Int J Essential Oil Ther 3:1–10
Garabadu D, Shah A, Ahmad A et al (2011) Eugenol as an anti-stress agent: modulation of hypothalamic-pituitary adrenal axis and brain monoaminergic systems in a rat model of stress. Stress 14:145–155
Garcia R, Ferreira JP, Costa G et al (2015) Evaluation of anti-inflammatory and analgesic activities of Cymbopogon citratus in vivo-polyphenols contribution. J Med Plants Res 9:1–13
Goes TC, Ursulino FR, Almeida-Souza TH et al (2015) Effect of lemongrass aroma on experimental anxiety in humans. J Altern Complement Med 21(12):766–773
Hanaa ARM, Sallam YI, Leithy ASE et al (2012) Lemongrass (Cymbopogon citratus) essential oil as affected by drying methods. AOAS 57(2):113–116
Hunskaar S, Fasmer OB, Hole K (1985) Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 14:69–76
Irie Y, Itokazu N, Anjiki N et al (2004) Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Brain Res 1011:243–246
Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203–210
Kehne JH, Kane JM, Miller FP et al (1992) MDL 27,531 selectively reverses strychnine-induced seizures in mice. Br J Pharmacol 106:910–916
Khadri A, Neffati M, Smiti S et al (2010) Antioxidant, antiacetylcholinesterase and antimicrobial activities of Cymbopogon schoenanthus L Spreng (lemon grass) from Tunisia. LWT Food Sci Technol 43(2):331–336
Kumar VR, Inamdar MN, Nayeemunnisa et al (2011) Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity. Asian Pac J Trop Med 4:658–660
La Rocca V, da Fonseca DV, Silva-Alves KS et al (2017) Geraniol Induces Antinociceptive Effect in Mice Evaluated in Behavioural and Electrophysiological Models. Basic Clin Pharmacol Toxicol 120(1):22–29
Lapczynski A, Bhatia SP, Foxenberg RJ et al (2008) Fragrance material review on geraniol. Food Chem Toxicol 11:160–170
Lara VM, Carregaro AB, Santurio DF et al (2016) Antimicrobial Susceptibility of Escherichia coli Strains Isolated from Alouatta spp Feces to Essential Oils. Evid Based Complement Alternat Med 2016:1643762
Macedo IT, Oliveira LM, Ribeiro WL et al (2015) Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus. Rev Bras Parasitol Vet 24:268–275
Melo MS, Sena LC, Barreto FJ et al (2010) Antinociceptive effect of citronellal in mice. Pharm Biol 48:411–416
Melo MS, Guimaraes AG, Santana MF et al (2011) Anti-inflammatory and redox-protective activities of citronellal. Biol Res 44:363–368
Nogueira AC, Carvalho RR, Souza CA et al (1995) Study on the embryofeto-toxicity of citral in the rat. Toxicology 96:105–113
Nwabuisi C (2002) Prophylactic effect of multi-herbal extract ‘Agbo-Iba’ on malaria induced in mice. East Afr Med J 79:343–346
Peisíno AL, Diogo DL, Mendes M et al (2005). Study of the drying effects in the composition of the essential oil of lemongrass (Cymbopogon citratus). In: 4th MERCOSUR congress on process systems engineering: 2nd MERCOSUR congress on chemical engineering: proceedings of ENPROMER 2005, Village Rio das Pedras, August 2005. vol 36.2006,4. E-papers serviçoseditoriais, Rio de Janeiro, pp 1–10
Pennacchio M, Jefferson L, Havens K (2010) Uses and Abuses of Plant-Derived Smoke: Its Ethnobotany as Hallucinogen, Perfume, Incense, and Medicine. Oxford University Press, Oxford, p 264
Perry N, Perry E (2006) Aromatherapy in the management of psychiatric disorders clinical and neuropharmacological perspectives. CNS Drugs 20(4):257–280
Quintans-Junior LJ, Souza TT, Leite BS et al (2008) Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine 15:619–624
Quintans-Junior LJ, Melo MS, De Sousa DP et al (2010) Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability. J Orofac Pain 24:305–312
Sagradas J, Costa G, Figueirinha A et al (2015) Gastroprotective effect of Cymbopogon citratus infusion on acute ethanol-induced gastric lesions in rats. J Ethnopharmacol 173:134–138
Santos Serafim MM, Ferreira Silva HB, Rios R et al (2015) The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Kappab) activation. BMC Complement Altern Med 15:168
Sen P, Maiti PC, Puri S et al (1992) Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals. Indian J ExpBiol 30:592–596
Shah G, Shiri R, Dhabiliya F et al (2010) Anti-anxiety activity of Cymbopogon citratus (dc) stapf leaves extracts on the elevated plus-maze model of anxiety in mice. Phcog J 2(15):45–50
Shah G, Shri R, Panchal V et al (2011) Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). J Adv Pharm Technol Res 2:3–8
Sharma R, Rao R, Kumar S et al (2019) Therapeutic potential of citronella essential oil: a review. Curr Drug Discov Technol 16(4):330–339
Silva MR, Ximenes RM, da Costa JG et al (2010) Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice. Naunyn Schmiedebergs Arch Pharmacol 381:415–426
Soenarko S (1977) The genus Cymbopogon Sprengel (Gramineae). Reinwardtia 9:225–375
Su YW, Chao SH, Lee MH et al (2010) Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin E(2)production in macrophages. Planta Med 76:1666–1671
Tao G, Irie Y, Li DJ et al (2005) Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorg Med Chem 13:4777–4788
Tavares F, Costa G, Francisco V et al (2015) Cymbopogon citratus industrial waste as a potential source of bioactive compounds. J Sci Food Agric 95:2652–2659
Toukourou H, Uwambayinema F, Yakoub Y et al (2020) In vitro and in vivo toxicity studies on Cymbopogon giganteus Chiov. Leaves essential oil from Benin. J Toxicol 12:1–12
Tsuji R, Isobe N, Kawasaki H (1996) Mechanism of prolongation of pentobarbital-induced sleeping time by empenthrin in mice. Toxicology 108:185–190
Umukoro S, Ogboh SI, Omorogbe O et al (2017) Evidence for the involvement of monoaminergic pathways in the antidepressant-like activity of Cymbopogon citratus in Mice. Drug Res (Stuttg) 67(7):419–424
Umukoro S, Adeola AH, Ben-Azu B et al (2018) Lemon Grass Tea Enhanced Memory Function and Attenuated Scopolamine-Induced Amnesia in Mice Via Inhibition of Oxidative Stress and Acetyl-Cholinesterase Activity. J Herbs Spices Med Plants 24(4):407–420
Viana GS, do Vale TG, Silva CM et al (2000a) Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown. Biol Pharm Bull 23(a):1314–1317
Viana GS, Vale TG, Pinho RS et al (2000b) Antinociceptive effect of the essential oil from Cymbopogon citratus in mice. J Ethnopharmacol 70(2):323–327
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Rojek, K., Serefko, A., Poleszak, E. et al. Neurobehavioral properties of Cymbopogon essential oils and its components. Phytochem Rev 21, 327–338 (2022). https://doi.org/10.1007/s11101-020-09734-0
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DOI: https://doi.org/10.1007/s11101-020-09734-0