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Vincamine by synthesis and semi-synthesis

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Abstract

This review summarizes the main strategies aimed at the total synthesis of vincamine and congeners. Then, our contribution in this field is presented: we describe (+)-vincamine semi-synthesis using tabersonine as starting material. Characterization and quantification of the main impurities are discussed, and HPLC conditions, structural elucidation and NMR data of four of them are reported.

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Authors and Affiliations

  1. Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133, Milan, Italy

    Elisa Bonandi, Francesca Foschi, Cristina Marucci & Daniele Passarella

  2. LINNEA SA, Via Cantonale 123, 6595, Riazzino, TI, Switzerland

    Giuseppe Paladino & Marcello Luzzani

Authors
  1. Elisa Bonandi
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  2. Francesca Foschi
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  3. Cristina Marucci
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  4. Giuseppe Paladino
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  5. Marcello Luzzani
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  6. Daniele Passarella
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Correspondence to Daniele Passarella.

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Bonandi, E., Foschi, F., Marucci, C. et al. Vincamine by synthesis and semi-synthesis. Phytochem Rev 20, 343–365 (2021). https://doi.org/10.1007/s11101-020-09702-8

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  • DOI: https://doi.org/10.1007/s11101-020-09702-8

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