A review of dietary stilbenes: sources and bioavailability

Phytochemistry Reviews volume 17, pages1007–1029(2018)Cite this article

Abstract

Stilbenes are a class of phenolic metabolites found in various edible plants, such as grapevine, berries and peanuts. Their bioactivitiy and their potential benefits for human health have been the subject of several studies. Among all identified stilbenes, resveratrol has been particularly studied and results from literature showed that it presents several biological activities, including antioxidant, anti-inflammatory and antiproliferative effects. Likewise, some researches focused on other stilbenes and highlighted similar biological activity for those compounds. However, stilbenes present a high diversity in their phenolic structures (various chemical substituents and polymerization) which is a determining factor of their absorption and metabolism rates. Consequently, this could affect the effectiveness of stilbenes in vivo. In this context, an evaluation of the bioavailability and metabolism of stilbenes is necessary to move forward with pharmacological and clinical studies. Hence, this review aims to present recently obtained data and results concerning stilbenes sources and bioavailability, as a contribution to the valorization of the role of dietary stilbenes in the human diet.

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Abbreviations

AUC:

Area under the curve

Cmax:

Maximal concentration

HSA:

Human serum albumin

SULT:

Sulfotransferases

UGT:

UDP glucuronosyl transferase

Vd:

Volume of distribution

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  1. Univ. Bordeaux, Unité de recherche Œnologie, Molécules d’Intérêt Biologique, EA 4577, USC 1366 INRA, ISVV, BxINP, Institut des Sciences de la Vigne et du Vin, 210 Chemin de Leysottes, 33882, Villenave d’Ornon cedex, France

    Toni El Khawand, Arnaud Courtois, Josep Valls, Tristan Richard & Stéphanie Krisa

  2. Centre Antipoison et de Toxicovigilance d’Aquitaine Poitou–Charentes, Bâtiment UNDR, CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France

    Arnaud Courtois

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El Khawand, T., Courtois, A., Valls, J. et al. A review of dietary stilbenes: sources and bioavailability. Phytochem Rev 17, 1007–1029 (2018). https://doi.org/10.1007/s11101-018-9578-9

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Keywords

  • Bioavailability
  • Metabolism
  • Pharmacokinetics
  • Stilbenes