Phytochemistry Reviews

, Volume 17, Issue 5, pp 1007–1029 | Cite as

A review of dietary stilbenes: sources and bioavailability

  • Toni El Khawand
  • Arnaud CourtoisEmail author
  • Josep Valls
  • Tristan Richard
  • Stéphanie Krisa


Stilbenes are a class of phenolic metabolites found in various edible plants, such as grapevine, berries and peanuts. Their bioactivitiy and their potential benefits for human health have been the subject of several studies. Among all identified stilbenes, resveratrol has been particularly studied and results from literature showed that it presents several biological activities, including antioxidant, anti-inflammatory and antiproliferative effects. Likewise, some researches focused on other stilbenes and highlighted similar biological activity for those compounds. However, stilbenes present a high diversity in their phenolic structures (various chemical substituents and polymerization) which is a determining factor of their absorption and metabolism rates. Consequently, this could affect the effectiveness of stilbenes in vivo. In this context, an evaluation of the bioavailability and metabolism of stilbenes is necessary to move forward with pharmacological and clinical studies. Hence, this review aims to present recently obtained data and results concerning stilbenes sources and bioavailability, as a contribution to the valorization of the role of dietary stilbenes in the human diet.


Bioavailability Metabolism Pharmacokinetics Stilbenes 



Area under the curve


Maximal concentration


Human serum albumin




UDP glucuronosyl transferase


Volume of distribution


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Authors and Affiliations

  1. 1.Univ. Bordeaux, Unité de recherche Œnologie, Molécules d’Intérêt Biologique, EA 4577, USC 1366 INRA, ISVV, BxINPInstitut des Sciences de la Vigne et du VinVillenave d’Ornon cedexFrance
  2. 2.Centre Antipoison et de Toxicovigilance d’Aquitaine Poitou–Charentes, Bâtiment UNDRCHU de BordeauxBordeauxFrance

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