Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae)

Abstract

The subfamily Barnadesioideae (Asteraceae) constitutes a group of spiny plants that are entirely restricted to South America and currently encompasses 92 species distributed in nine genera. Barnadesioideae is particularly interesting because this subfamily constitutes the sister group of all other Asteraceae, and provides insights into the early evolution of Asteraceae. The present work summarizes the current knowledge of the chemistry and medicinal uses of Barnadesioideae. The up-to-date phytochemical profile of Barnadesioideae is composed of phenolic compounds, flavonoids, and triterpenoids, representing 39 different compounds described in 45 species of the subfamily. The presumable absence of sesquiterpene lactones—the typical Asteraceae taxonomical markers—in members of Barnadesioideae is also discussed. A few members of the genera Barnadesia, Dasyphyllum, and more frequently, Chuquiraga, are reported in the traditional medicine of Argentina, Brazil, Bolivia, Chile, Colombia, Ecuador, and Peru, where they are known for their antitussive, expectorant, anti-inflammatory, and many other properties. Chuquiraga jussieui, Chuquiraga spinosa, and Chuquiraga weberbaueri are species frequently sold in medicinal plant markets of Ecuador and Peru, where they are commonly recommended for the relief of genitourinary and reproductive disorders in women and men. Some phytopharmaceuticals containing C. spinosa are also marketed in Europe and North America. Further phytochemical studies on the members of Barnadesioideae would be of great interest for the chemotaxonomy of the family Asteraceae. Moreover, profiling the phytochemical composition of those medically important Barnadesioideae would support their uses in traditional medicine.

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References

  1. Abad C, González J, Chamorro A (2009) El Apu Pariacaca y el Alto Cañete: Estudio de paisaje cultural. Instituto Nacional de Cultura, Lima

    Google Scholar 

  2. Alberto MR, Zampini IC, Isla MI (2009) Inhibition of cyclooxygenase activity by standardized hydroalcoholic extracts of four Asteraceae species from the Argentine Puna. Braz J Med Biol Res 42:787–790

    Article  CAS  PubMed  Google Scholar 

  3. Anderson H (1867) Notes on some of the Compositae of the Andes, and more particularly on Chuquiraga insignis. Trans Proc Bot Soc Edinb 9:115–118

    Google Scholar 

  4. Ansaloni R, Wilches I, León F et al (2010) Estudio preliminar sobre plantas medicinales utilizadas en algunas comunidades de las provincias de Azuay, Cañar y Loja, para afecciones del aparato gastrointestinal. Revista Tecnológica ESPOL 23:89–97

    Google Scholar 

  5. Arroyo-Acevedo J, Herrera-Calderón O, Chávez-Asmat R et al (2017) Protective effect of Chuquiraga spinosa extract on N-methyl-nitrosourea (NMU) induced prostate cancer in rats. Prostate Int 5:47–52

    Article  PubMed  PubMed Central  Google Scholar 

  6. Barbarán FR (2008) Medicinal plants of the Argentinean Puna: a common property resource and an opportunity for local people. In: Proceedings of the twelfth biennial conference of the international association for the study of commons. Indiana University, Cheltenham, 14–18 July 2008

  7. Bohlmann F, Zdero C, Schmeda-Hirschmann G et al (1986) Dimeric guaianolides and other constituents from Gochnatia species. Phytochemistry 25:1175–1178

    Article  CAS  Google Scholar 

  8. Bohm BA, Stuessy TF (1995) Flavonoid chemistry of Barnadesioideae (Asteraceae). Syst Bot 20:22–27

    Article  Google Scholar 

  9. Bohm BA, Stuessy TF (2001) Flavonoids of the sunfower family (Asteraceae). Springer, Wien

    Google Scholar 

  10. Brack A (1999) Diccionario enciclopédico de plantas útiles del Perú. Centro Bartolomé de Las Casas, Cusco

    Google Scholar 

  11. Bremer K, Jansen RK (1992) A new subfamily of the Asteraceae. Ann Mo Bot Gard 79:414–415

    Article  Google Scholar 

  12. Buitron XC (1999) Ecuador: uso y comercio de pantas medicinales, situación actual y aspectos importantes para su conservación. TRAFFIC International, Cambridge

    Google Scholar 

  13. Bussmann RW, Glenn A (2010) Medicinal plants used in Northern Peru for reproductive problems and female health. J Ethnobiol Ethnomed 6:30

    Article  PubMed  PubMed Central  Google Scholar 

  14. Bussmann RW, Sharon D (2006a) Traditional plant use in Northern Peru: tracking two thousand years of healing culture. J Ethnobiol Ethnomed 2:47

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bussmann RW, Sharon D (2006b) Traditional medicinal plant use in Loja province, Southern Ecuador. J Ethnobiol Ethnomed 2:44

    Article  PubMed  PubMed Central  Google Scholar 

  16. Bussmann RW, Sharon D (2015) Medicinal plants of the Andes and the Amazon—the magic and medicinal flora of Northern Peru. William L. Brown Center, St. Louis

    Google Scholar 

  17. Bussmann RW, Sharon D, Vandebroek I et al (2007) Health for sale: the medicinal plant markets in Trujillo and Chiclayo, Northern Peru. J Ethnobiol Ethnomed 3:37

    Article  PubMed  PubMed Central  Google Scholar 

  18. Bussmann RW, Sharon D, Perea FA et al (2008) Antibacterial activity of Northern-Peruvian medicinal plants. Arnaldoa 15:127–148

    Google Scholar 

  19. Bussmann RW, Glenn A, Meyer K et al (2010) Herbal mixtures in traditional medicine in Northern Peru. J Ethnobiol Ethnomed 6:10

    Article  PubMed  PubMed Central  Google Scholar 

  20. Bussmann RW, Malca G, Glenn A et al (2011) Toxicity of medicinal plants used in traditional medicine in Northern Peru. J Ethnopharmacol 137:121–140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Bussmann RW, Paniagua-Zambrana N, Castaneda Sifuentes RY et al (2015) Health in a pot-the ethnobotany of emolientes and emolienteros in Peru. Econ Bot 69:83–88

    Article  Google Scholar 

  22. Bussmann RW, Paniagua Zambrana NY, Moya Huanca LA, Hart R (2016) Changing markets—medicinal plants in the markets of La Paz and El Alto, Bolivia. J Ethnopharmacol 193:76–95

    Article  PubMed  Google Scholar 

  23. Cabrera AL (1951) Huarpea, nuevo género de Compuestas. Bol Soc Argent Bot 4:129–132

    Google Scholar 

  24. Cabrera AL (1959) Revisión del género Dasyphyllum (Compositae). Rev Mus La Plata 9(38):21–100

    Google Scholar 

  25. Cabrera AL (1997) Nota crítica en la tribu Mutisieae (Compositae) para la flora de Paraguay. Candollea 52:216

    Google Scholar 

  26. Calabria LM, Emerenciano VP, Ferreira MJP et al (2007) A phylogenetic analysis of tribes of the Asteraceae based on phytochemical data. Nat Prod Commun 2:277–285

    CAS  Google Scholar 

  27. Calabria LM, Emerenciano VP, Scotti MT, Mabry TJ (2009) Secondary chemistry of compositae. In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  28. Camaqui AM (2007) Plantas medicinales. La experiencia de Tinguipaya. Editorial Gente Común, La Paz

    Google Scholar 

  29. Campos-Navarro R, Scarpa GF (2013) The cultural-bound disease “empacho” in Argentina. A comprehensive botanico-historical and ethnopharmacological review. J Ethnopharmacol 148:349–360

    Article  CAS  PubMed  Google Scholar 

  30. Carullo G, Cappello AR, Frattaruolo L, Badolato M, Armentano B, Aiello F (2017) Quercetin and derivatives: useful tools in inflammation and pain management. Future Med Chem 9:79–93

    Article  CAS  PubMed  Google Scholar 

  31. Casado R, Landa A, Calvo J et al (2011) Anti-inflammatory, antioxidant and antifungal activity of Chuquiraga spinosa. Pharm Biol 49:620–626

    Article  CAS  PubMed  Google Scholar 

  32. Castelucci S, de Paula Rogerio A, Ambrosio SR et al (2007) Anti-inflammatory activity of Dasyphyllum brasiliensis (Asteraceae) on acute peritonitis induced by beta-glucan from Histoplasma capsulatum. J Ethnopharmacol 112:192–198

    Article  PubMed  Google Scholar 

  33. Ceuterick M, Vandebroek I, Pieroni A (2011) Resilience of Andean urban ethnobotanies: a comparison of medicinal plant use among Bolivian and Peruvian migrants in the United Kingdom and in their countries of origin. J Ethnopharmacol 136:27–54

    Article  PubMed  Google Scholar 

  34. Ching-Wen C, Yun-Chieh C, Yu-Chin L, Wen-Huang P (2017) p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models. J Med 71(2):422–432

    Google Scholar 

  35. Collins J (1870) Notes on some new little-known vegetable products. Pharm J Trans 11:66–67

    Google Scholar 

  36. Da Costa FB, Schorr K, Arakawa NS, Schilling EE, Spring Otmar (2001) Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera species (Heliantheae; Asteraceae). J Braz Chem 12:403–407

    Article  Google Scholar 

  37. Da Costa FB, Terfloth L, Gasteiger J (2005) Sesquiterpene-lactone based classification of three Asteraceae tribes: a study based on self-organizing neural networks applied to chemosystematics. Phytochemistry 66:345–353

    Article  CAS  PubMed  Google Scholar 

  38. De Feo V (2003) Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices. J Ethnopharmacol 85:243–256

    Article  PubMed  Google Scholar 

  39. de Kraker JW, Franssen MC, Dalm MC et al (2001) Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450(+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis. Plant Physiol 125:1930–1940

    Article  PubMed  PubMed Central  Google Scholar 

  40. de Kraker JW, Franssen MC, Joerink M et al (2002) Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant Physiol 129:257–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. de la Torre L, Alarcón DS, Kvist LP, Lecaro JS (2008) Usos medicinales de las plantas. In: de la Torre L, Navarrete H, Muriel PM et al (eds) Enciclopedia de las plantas útiles del Ecuador. Herbario QCA & Herbario AAU, Quito & Aarhus

  42. de Mösbach EW (1991) Botánica Indígena de Chile. Editorial Andrés Bello, Santiago de Chile

    Google Scholar 

  43. De-la-Cruz H, Vilcapoma G, Zevallos PA (2007) Ethnobotanical study of medicinal plants used by the Andean people of Canta, Lima, Peru. J Ethnopharmacol 111:284–294

    Article  PubMed  Google Scholar 

  44. Díaz-Piedrahita S, Vélez-Nauer C (1993) Revisión de las tribus Barnadesieae y Mutisieae (Asteraceae) para la flora de Colombia. Jardín Botánico José Celestino Mutis, Bogotá

    Google Scholar 

  45. Duenas AA, Alcivar UE, Olazabal E, Cortes R (2014) Efecto antioxidante de la Chuquiraga jussieui J.F.Gmel en el ensayo de hemólisis. Medicent Electrón 18:57–64

    Google Scholar 

  46. Duke JA, Bogenschutz-Godwin MJ, Ottensen AR (2009) Duke’s handbook of medicinal plants of Latin America. CRC Press, Boca Raton

    Google Scholar 

  47. Estomba D, Ladio A, Lozada M (2006) Medicinal wild plant knowledge and gathering patterns in a Mapuche community from North-western Patagonia. J Ethnopharmacol 103:109–119

    Article  PubMed  Google Scholar 

  48. Ezcurra C (1985) Revisión del género Chuquiraga (Compositae: Mutisieae). Darwiniana 26:219–284

    Google Scholar 

  49. Flagg ML, Valcic S, Montenegro G et al (1999) Pentacyclic triterpenes from Chuquiraga ulicina. Phytochemistry 52:1345–1350

    Article  CAS  PubMed  Google Scholar 

  50. Funk VA, Roque N (2011) The monotypic Andean genus Fulcaldea (Compositae, Barnadesioideae) gains a new species from northeastern Brazil. Taxon 60:1095–1103

    Google Scholar 

  51. Funk VA, Bayer RJ, Keeley S et al (2005) Everywhere but Antarctica: using a super tree to understand the diversity and distribution of the Compositae. Biol Skr 55:343–374

    Google Scholar 

  52. Gálvez M, Pastor A (1996) Estudio fitoquímico de la Chuquiraga spinosa. Revista de Química 10:133–134

    Google Scholar 

  53. Giberti GC (1983) Herbal folk medicine in northwestern Argentina: Compositae. J Ethnopharmacol 7:321–341

    Article  CAS  PubMed  Google Scholar 

  54. Gioti K, Tenta R (2015) Bioactive natural products against prostate cancer: mechanism of action and autophagic/apoptotic molecular pathways. Planta Med 81:543–562

    Article  CAS  PubMed  Google Scholar 

  55. Granada A (1997) Una nueva especie de Chuquiraga (Asteraceae, Mutisieae) del Perú. Kurtziana 25:151–156

    Google Scholar 

  56. Gruenstaeudl M, Urtubey E, Jansen RK et al (2009) Phylogeny of Barnadesioideae (Asteraceae) inferred from DNA sequence data and morphology. Mol Phylogenet Evol 51:572–587

    Article  CAS  PubMed  Google Scholar 

  57. Gupta MP (2006) Medicinal plants originating in the Andean high plateau and central valleys region of Bolivia, Ecuador and Peru. UNIDO report, United Nations

  58. Gurovic MS, Castro MJ, Richmond V et al (2010) Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae). Planta Med 76:607–610

    Article  CAS  PubMed  Google Scholar 

  59. Harling G (1991) Compositae-Mutisieae. In: Harling G, Andersson L (eds) Flora of Ecuador, vol 42. University of Götenborg, Göteborg

    Google Scholar 

  60. Herrera FL (1933) Plantarum Cuzcorum Herrerarianum. Estudios sobre la flora del departamento del Cuzco. Sanruarti, Lima

    Google Scholar 

  61. Herrera FL (1938) Plantas que curan y plantas que matan de la flora del Cuzco. Revista Universitaria 75:4–76

    Google Scholar 

  62. Herrera-Calderon O, Tinco-Jayo JA, Franco-Quino C et al (2017) Antioxidant activity and cytotoxic profile of Chuquiraga spinosa Lessing on human tumor cell lines: a promissory plant from Peruvian flora. Asian Pac J Trop Dis 7:304–308

    Article  Google Scholar 

  63. Hind DJN (2001) A new species of Barnadesia (Compositae: Barnadesieae) from Bolivia. Kew Bull 56:705–710

    Article  Google Scholar 

  64. Hind N, Hall T (2003) Plate 459. Barnadesia arborea Compositae. Curtis’s Bot Mag 20:25–30

    Article  Google Scholar 

  65. Hoeneisen M, Rojas A, Bittner M et al (2000) Constituents of Chuquiraga atacamensis and C. ulicina. Bol Soc Chil Quim 45:49–52

    CAS  Google Scholar 

  66. Huamantupa I, Cuba M, Urrunaga R et al (2011) Riqueza, uso y origen de plantas medicinales expendidas en los mercados de la ciudad del Cusco. Rev Peru Biol 18:283–291

    Google Scholar 

  67. Jadán MB, Orquera GX, Mihai RA (2014) Establishment of an in vitro culture protocol of Chuquiraga jussieui J.F.Gmel. from apical and axillary buds. Rom Biotechnol Lett 19:9984–9991

    Google Scholar 

  68. Jansen RK, Palmer JD (1987) A chloroplast DNA inversion marks an ancient evolutionary split in the sunflower family (Asteraceae). Proc Natl Acad Sci USA 84:5818–5822

    Article  CAS  PubMed  Google Scholar 

  69. Juárez BE, Mendiondo ME (2002a) Flavonoides en Chuquiraga acanthophylla Weddell subfamilia Barnadesioideae (Asteraceae). In: I Congreso Latinoamericano de Fitoquímica, IV Reunion de la sociedad Latinoamericana de Fitoquimica, Buenos Aires, 8–10 May 2002

  70. Juárez BE, Mendiondo ME (2002b) Flavonoid chemistry of Chuquiraga (Asteraceae). Biochem Syst Ecol 30:371–373

    Article  Google Scholar 

  71. Juárez BE, Mendiondo ME (2007) Significado quimiotaxonomico de los flavonoides presentes en Doniophyton anomallum (D. Don) Kurtz (Asteraceae). B Latinoam Caribe PL 6:252–253

    Google Scholar 

  72. Katinas L, Stuessy TF (1997) Revision of Doniophyton (Compositae, Barnadesioideae). Plant Syst Evol 206:33–45

    Article  Google Scholar 

  73. Kim K-J, Choi K-S, Jansen RK (2005) Two chloroplast DNA inversions originated simultaneously during the early evolution of the sunflower family (Asteraceae). Mol Biol Evol 22:1783–1792

    Article  CAS  PubMed  Google Scholar 

  74. Ladio AH, Lozada M (2009) Human ecology, ethnobotany and traditional practices in rural populations inhabiting the Monte region: resilience and ecological knowledge. J Arid Environ 73:222–227

    Article  Google Scholar 

  75. Landa A, Casado R, Calvo MI (2009) Identification and quantification of flavonoids from Chuquiraga spinosa (Asteraceae). Nat Prod Commun 4:1353–1355

    CAS  PubMed  Google Scholar 

  76. Lundberg J (2009) Asteraceae and relationships within Asterales. In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  77. Macía MJ, García E, Vidaurre PJ (2005) An ethnobotanical survey of medicinal plants commercialized in the markets of La Paz and El Alto, Bolivia. J Ethnopharmacol 97:337–350

    Article  PubMed  Google Scholar 

  78. Madaleno IM (2007) Etno-farmacología en Iberoamérica, una alternativa a la globalización de las prácticas de cura. Cuadernos Geográficos 41:61–95

    Google Scholar 

  79. Madaleno IM (2012) Organic cultivation and use of medicinal plants in Latin America. Pharmacogn Commn 2:34–51

    Article  CAS  Google Scholar 

  80. Martínez CEC (2006) Plantas medicinales de los Andes Ecuatorianos. In: Moraes MR, Øllgaard B, Kvist LP et al (eds) Botánica Económica de los Andes Centrales. Universidad Mayor de San Andrés, La Paz

    Google Scholar 

  81. Mendiondo ME, Juárez BE (2001) Flavonoids of Doniophyton patagonicum (Phil.) Hieron. (Asteraceae). Biochem Syst Ecol 29:437–438

    Article  CAS  PubMed  Google Scholar 

  82. Mendiondo ME, Juarez BE, Seeligmann P (1997) Flavonoid patterns of some Barnadesioideae (Asteraceae). Eventual chemosystematic significance. Biochem Syst Ecol 25:673–674

    Article  CAS  Google Scholar 

  83. Mendiondo ME, Juárez BE, Seeligmann P (2000) Flavonoid profiles of some Argentine species of Chuquiraga (Asteraceae). Biochem Syst Ecol 28:283–285

    Article  CAS  Google Scholar 

  84. Mendiondo ME, Juárez BE, Zampini C et al (2011) Bioactivities of Chuquiraga straminea Sandwith. Nat Prod Commun 6:965–968

    CAS  PubMed  Google Scholar 

  85. Monigatti M, Bussmann RW, Weckerle CS (2012) Medicinal plant use in two Andean communities located at different altitudes in the Bolívar Province, Peru. J Ethnopharmacol 145:450–464

    Article  PubMed  Google Scholar 

  86. Mostacero J, Castillo F, Mejia FR et al (2011) Plantas medicinales del Perú. Taxonomía, ecogeografía, fenología y etnobotánica. Asamblea Nacional de Rectores, Lima

    Google Scholar 

  87. Nguyen DT, Göpfert JC, Ikezawa N et al (2010) Biochemical conservation and evolution of germacrene A oxidase in Asteraceae. J Biol Chem 285:16588–16598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Nguyen TD, Faraldos JA, Vardakou M et al (2016) Discovery of germacrene A synthases in Barnadesia spinosa: the first committed step in sesquiterpene lactone biosynthesis in the basal member of the Asteraceae. Biochem Biophys Res Commun 479:622–627

    Article  CAS  PubMed  Google Scholar 

  89. Padilla-Gonzalez GF, dos Santos FA, Da Costa FB (2016) Sesquiterpene lactones: more than protective plant compounds with high toxicity. Crit Rev Plant Sci 35:18–37

    Article  CAS  Google Scholar 

  90. Panero JL, Funk VA (2008) The value of sampling anomalous taxa in phylogenetic studies: major clades of the Asteraceae revealed. Mol Phylogenet Evol 47:757–782

    Article  CAS  PubMed  Google Scholar 

  91. Passoni FD, Carollo C, Gobbo-Neto L et al (2008) Polifenóis na fração ativa de espinho-agulha (Dasyphyllum brasiliense, Asteraceae), uma planta medicinal com atividade antiinflamatória. In: 31a Reunião Anual da Sociedade Brasileira de Química, Águas de Lindóia, 26–29 May 2008

  92. Paula CS, Verdam MCS, Souza AM et al (2013) Prospecção fitoquímica e avaliação preliminar da atividade antibacteriana dos extratos das folhas e casca do caule de Dasyphyllum tomentosum (Spreng.) Cabrera. Visão Acadêmica 14:4–12

    Google Scholar 

  93. Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63:1035–1042

    Article  CAS  PubMed  Google Scholar 

  94. Quattrocchi U (2012) CRC world dictionary of plant names: common names, scientific names, eponyms, synonyms, and etymology. CRC Press, New York

    Google Scholar 

  95. Raad K (2012) Medicina ancestral de los Amaychas. Amagrafik, Tucuman

    Google Scholar 

  96. Ramírez C, Beloso C (2002) Usos tradicionales de las plantas en la Meseta Patagónica. Jardín Botánico de la Patagonia Extraandina. CENPAT-CONICET-ICBG. Dirección de Impresiones Oficiales, Chubut

  97. Rehecho S, Uriarte-Pueyo I, Calvo J et al (2011) Ethnopharmacological survey of medicinal plants in Nor-Yauyos, a part of the landscape reserve Nor-Yauyos-Cochas, Peru. J Ethnopharmacol 133:75–85

    Article  PubMed  Google Scholar 

  98. Ribeiro D, Freitas M, Tomé SM, Silva AM, Laufer S, Lima JL, Fernandes E (2015) Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood. Inflammation 38:858–870

    Article  CAS  PubMed  Google Scholar 

  99. Richeri M, Ladio AH, Beeskow AM (2013) Conocimiento tradicional y autosuficiencia: la herbolaria rural en la meseta central del Chubut (Argentina). B Latinoam Caribe PL 12:44–58

    Google Scholar 

  100. Roersch C (1994) Plantas medicinales en el sur andino del Peru. Koeltz Scientific Books, Koenigstein

    Google Scholar 

  101. Rondina RVD, Bandoni AL, Coussio JD (2008) Especies medicinales argentinas con potencial actividad analgésica. Dominguezia 24:47–69

    Google Scholar 

  102. Saavedra MM, Monge M, Guimarães EF (2014) Dasyphyllum diamantinense (Asteraceae, Barnadesioideae): a new species from the Chapada Diamantina, Bahia State, Brazil. Phytotaxa 174:231–236

    Article  Google Scholar 

  103. Sagástegui AA (1980) Compuestas andino-peruanas nuevas para la ciencia. Bol Soc Argent Bot 19:61–68

    Google Scholar 

  104. Sagástegui AA, Dillon MO (1985) Four new species of Asteraceae from Peru. Brittonia 37:6–13

    Article  Google Scholar 

  105. Sagástegui AA, Sánchez VL (1991) Una nueva especie de Chuquiraga (Asteraceae, Mutisieae) del norte del Perú. Arnaldoa 1:1–4

    Google Scholar 

  106. Sala A, Recio MC, Giner RM, Máñez S, Ríos JL (2001) New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity. J Nat Prod 64:1360–1362

    Article  CAS  PubMed  Google Scholar 

  107. Seamann FC (1982) Sesquiterpene lactones as taxonomic characters in the Asteraceae. Bot Rev 48:121–594

    Article  Google Scholar 

  108. Senatore F (1996) Composition of the essential oil of Chuquiraga spinosa (R. et P.) D. Don. Flav Frag J 11:215–217

    Article  CAS  Google Scholar 

  109. Senatore F, Nunziata A, D’Agostino M, de Feo V (1999) Flavonol glycosides and p-hydroxyacetophenone from Chuquiraga spinosa. Pharm Biol 37:366–368

    Article  CAS  Google Scholar 

  110. Shahidi F, Chandrasekara A (2010) Hydroxycinnamates and their in vitro and in vivo antioxidant activities. Phytochem Rev 9:147–170

    Article  CAS  Google Scholar 

  111. Siura SC, Flores MP (2010) Etnobotánica de las plantas medicinales de las comunidades campesinas de Quero y Masma Chicche. In: Gallo MP, Galarza VG, Gabriel JM, Moris G (eds) Las plantas medicinales del Perú: etnobotánica y viabilidad comercial. Los libros de la Catarata, Madrid

    Google Scholar 

  112. Soubeiran L (1868) Extrait du proces-verbal de la séance de la Société de pharmaie de Paris. Journal de Pharmacie et de Chimie 4(8):303

    Google Scholar 

  113. Spring O (1989) Microsampling: an alternative approach using sesquiterpene lactones for systematics. Biochem Syst Ecol 17:509–517

    Article  CAS  Google Scholar 

  114. Spring O (2000) Chemotaxonomy based on metabolites from glandular trichomes. In: Hallahan DL, Gray JC (ed) Plant trichomes, advances in botanical research, vol 31. Academic Press, London, pp 153–174

    Google Scholar 

  115. Stuessy TF, Sagástegui AA (1993) Revisión de Arnaldoa (Compositae, Barnadesioideae), género endémico del Norte del Perú. Arnaldoa 1:9–21

    Google Scholar 

  116. Stuessy TF, Urtubey E, Gruenstaeudl M (2009) Barnadesieae (Barnadesioideae). In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  117. Tene V, Malagón O, Finzi PV et al (2007) An ethnobotanical survey of medicinal plants used in Loja and Zamora-Chinchipe, Ecuador. J Ethnopharmacol 111:63–81

    Article  PubMed  Google Scholar 

  118. Torres H, Borel R, Bustamante N, Centeno MI (1992) Usos tradicionales de arbustos nativos en el sur de Puno. Publifor, Puno

    Google Scholar 

  119. Ulloa Ulloa C, Jørgensen PM, Dillon MO (2002) Arnaldoa argentea (Barnadesioideae: Asteraceae) a new species and a new generic record for Ecuador. Novon 12:415–419

    Article  Google Scholar 

  120. Urtubey E (1999) Revisión del género Barnadesia (Asteraceae: Barnadesioideae, Barnadesieae). Ann Mo Bot Gard 86:57–117

    Article  Google Scholar 

  121. Vandebroek I, Thomas E, AMETRAC (2003) Plantas medicinales para la atención primaria de la salud. El conocimiento de ocho médicos tradicionales de Apillapampa (Bolivia). Industrias Graficas Serrano, Cochabamba

    Google Scholar 

  122. Vásquez LN, Escurra JP, Aguirre RT et al (2010) Plantas medicinales del Norte del Perú. Universidad Nacional Pedro Ruiz Gallo, Lambayeque

    Google Scholar 

  123. Villagrán C, Castro V, Sánchez G et al (1998) La tradición surandina del desierto: Etnobotánica del área del Salar de Atacama (Provincia de El Loa, Región de Antofagasta, Chile). Estudios Atacameños 16:7–105

    Google Scholar 

  124. Villagrán C, Romo M, Castro V (2003) Etnobotánica del sur de los Andes de la primera región de Chile: un enlace entre las culturas altiplánicas y las de quebradas altas del Loa Superior. Chungara 35:73–124

    Google Scholar 

  125. Yakovleff E, Herrera FH (1934) El mundo vegetal de los antiguos Peruanos. Rev Mus Nac/Lima 3:240–322

    Google Scholar 

  126. Yang F, Song L, Wang H, Wang J, Xu Z, Xing N (2015) Quercetin in prostate cancer: chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential. Oncol Rep 33:2659–2668

    Article  CAS  PubMed  Google Scholar 

  127. Zamora VHC (2008) Estudio de aproximaciones etnobotánicas en áreas productoras del intersalar de Quinua Real del departamento de Potosi (Parte I). Fundacion Alitapo, Potosi

    Google Scholar 

  128. Zampini IC, Cudmani N, Isla MI (2007) Actividad antimicrobiana de plantas medicinales argentinas sobre bacterias antibiótico-resistentes. Acta Bioquim Clin L 41:385–393

    Google Scholar 

  129. Zampini IC, Cuello S, Alberto MR et al (2009) Antimicrobial activity of selected plant species from “the Argentine Puna” against sensitive and multi-resistant bacteria. J Ethnopharmacol 124:499–505

    Article  CAS  PubMed  Google Scholar 

  130. Zampini IC, Ordoñez RM, Isla MI (2010) Autographic assay for the rapid detection of antioxidant capacity of liquid and semi-solid pharmaceutical formulations using ABTS∙+ immobilized by gel entrapment. AAPS PharmSciTech 11:1159–1163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Zardini EM, Soria N (1994) A new species of Dasyphyllum (Asteraceae–Mutisieae) from Paraguay. Novon 4:80–82

    Article  Google Scholar 

  132. Zdero C, Bohlmann F (1990) Systematics and evolution within the Compositae, seen with the eyes of a chemist. Plant Syst Evol 171:1–14

    Article  Google Scholar 

  133. Zdero C, Bohlmann F, King RM, Robinson H (1986a) Further 5-methyl coumarins and other constituents from the subtribe mutisiinae. Phytochemistry 25:509–516

    Article  CAS  Google Scholar 

  134. Zdero C, Bohlmann F, King RM, Robinson H (1986b) α-Isocedrene derivatives, 5-methyl coumarins and other constituents from the subtribe Nassauviinae of the Compositae. Phytochemistry 25:2873–2882

    Article  CAS  Google Scholar 

  135. Zdero C, Bohlmann F, King RM (1987) Chemistry of the Barnadesiinae (Asteraceae). Phytologia 63:313–315

    Google Scholar 

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Acknowledgements

The authors acknowledge the Brazilian research funding agencies Foundation for the Coordination and Improvement of Higher Level or Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq), and São Paulo Research Foundation (FAPESP, Grants #2014/16850-6 and #2014/26866-7) for fellowship and funding. Mr. G.F. Padilla-González (FCFRP-USP) is acknowledged for his comments on the manuscript. We thank Dr. G. Shimizu (Inst. Biology, UNICAMP) and Dr. G. Heiden (EMBRAPA Temperate Agriculture) for providing pictures of Barnadesioideae. We also acknowledge Prof. Dr. M. Groppo Jr. (Dept. Biology, FFCLRP-USP) and Prof. Dr. J. Semir (Inst. Biology, UNICAMP) for their valuable support and discussions.

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Correspondence to Fernando B. Da Costa.

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Ccana-Ccapatinta, G.V., Monge, M., Ferreira, P.L. et al. Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae). Phytochem Rev 17, 471–489 (2018). https://doi.org/10.1007/s11101-017-9544-y

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Keywords

  • Barnadesioideae
  • Flavonoids
  • Triterpenoids
  • Traditional medicine