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Paradigm shift in natural product research: traditional medicine inspired approaches

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Abstract

The development of traditional medicine with the perspectives of safety, efficacy and quality would help not only to preserve the traditional heritage but also to rationalize the use of herbal medicine in the human healthcare. Nature is considered as a compendium for templates of new chemical entities. The medicinal plants mentioned in the different ancient texts worldwide may be explored with the modern scientific approaches for better leads in the healthcare. Drugs from medicinal plants are unique for their chemical and biological features, and are gaining global acceptance because they offer natural ways to treat diseases and promote healthcare. Natural products are the best sources of chemical diversity for finding new drugs and leads. Globalization of traditional medicine is necessary for health care with assessment of its safety, efficacy, therapeutic and clinical evidence. Evidence based validation of the ethnopharmacological claims on traditional medicine is necessary for its promotion and development. Applications of techniques such as marker analysis, DNA bar coding, plant metabolomics, network pharmacology etc. are being taken into account for the validation and documentation of medicinal plants. This can be achieved by the scientific exploitation of the established facts from ancient systems through proper validation of the claims based on pharmacological and phytochemical assessments.

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Abbreviations

AYUSH:

Ayurveda, Yoga, Unani, Siddha and Homeopathy

ADME:

Absorption, distribution, metabolism and elimination

GC–MS:

Gas chromatography and mass spectrometry

HPLC:

High performance liquid chromatography

HPTLC:

High performance thin layer chromatography

HTS:

High-throughput screening

LC–MS:

Liquid chromatography and mass spectrometry

NCEs:

New chemical entities

NDDS:

Novel drug delivery system

NMR:

Nuclear magnetic resonance

TM:

Traditional medicine

UV:

Ultraviolet

WHO:

World Health Organization

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Acknowledgements

The authors would like to express their deep gratitude to the Department of Biotechnology, Government of India, New Delhi, for financial support through Tata Innovation Fellowship (D.O. No. BT/HRD/35/01/04/2014) to P.K.M.

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Authors and Affiliations

  1. School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India

    Pulok K. Mukherjee, Shiv Bahadur, Ranjit K. Harwansh, Sayan Biswas & Subhadip Banerjee

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  1. Pulok K. Mukherjee
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  2. Shiv Bahadur
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  3. Ranjit K. Harwansh
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  4. Sayan Biswas
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  5. Subhadip Banerjee
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Correspondence to Pulok K. Mukherjee.

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Mukherjee, P.K., Bahadur, S., Harwansh, R.K. et al. Paradigm shift in natural product research: traditional medicine inspired approaches. Phytochem Rev 16, 803–826 (2017). https://doi.org/10.1007/s11101-016-9489-6

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